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Epidermal growth factor

Epidermal Growth Factor, EGF
This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: EGFR, CAN, HAD, V1a, Akt
Papers using Epidermal Growth Factor antibodies
A novel U-STAT3-dependent mechanism mediates the deleterious effects of chronic nicotine exposure on renal injury
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Goumans Marie Jose, In PLoS ONE, 2011
... Epidermal growth factor (EGF) was from BD Biosciences (San Jose, CA, USA) ...
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation.
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Parsons Maddy, In PLoS ONE, 2008
... similar densities were washed and starved in DMEM medium for two hours before addition of EGF (Biovision, Mountainview, CA) to 30 ...
Multiphoton time-domain fluorescence lifetime imaging microscopy: practical application to protein–protein interactions using global analysis
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Kong Anthony et al., In Oncotarget, 2008
... HER ligands, EGF and heregulin were purchased from Sigma Aldrich.
EMT 2.0: shaping epithelia through collective migration
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Hudson Laurie G. et al., In Dermatology Research and Practice, 2008
... Murine epidermal growth factor (EGF) was obtained from Biomedical Technologies Inc ...
SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors
Supplier
Pfeffer Suzanne, In PLoS Biology, 2007
... (Roche Diagnostics); transferrin receptor (Zymed Laboratories); EEA1 and annexin A1 (Transduction Laboratories); human LAMP1 (Pharmacia); EGF receptor (BD Biosciences); α-tubulin (Sigma-Aldrich); ubiquitinated proteins ...
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Papers on Epidermal Growth Factor
ANNALS EXPRESS: Cytokine profiles in overweight and obese subjects and normal weight individuals matched for age and gender.
New
Ghayour-Mobarhan et al., Mashhad, Iran. In Ann Clin Biochem, Feb 2016
The concentrations of serum interleukin-1α, -1β, -2, -4, -6, -8 and -10 (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10), were measured in all subjects, together with serum vascular endothelial growth factor (VEGF), interferon γ (IFN-γ), epidermal growth factor (EGF), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α).
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
New
Impact
Yang et al., Houston, United States. In Nat Cell Biol, Feb 2016
Here, we identify a cytoplasmic lncRNA, LINK-A (long intergenic non-coding RNA for kinase activation), which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1α phosphorylation at Tyr 565 and Ser 797 by BRK and LRRK2, respectively.
Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.
New
Kawamoto et al., Yokohama, Japan. In Plos Genet, Jan 2016
Activation of Stat3 is mainly positioned downstream of EGF-R as its ablation in TEC phenocopies the loss of Stat3 expression in these cells.
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
New
Impact
Hanash et al., New York City, United States. In Nature, Jan 2016
The intestinal stem cell (ISC) niche provides Wnt, Notch and epidermal growth factor (EGF) signals supporting Lgr5(+) crypt base columnar ISCs for normal epithelial maintenance.
Assessment of cytology based molecular analysis to guide targeted therapy in advanced non-small-cell lung cancer.
New
Ying et al., Beijing, China. In Oncotarget, Jan 2016
UNASSIGNED: To investigate the use of molecular testing on cytological specimens in selecting advanced non-small cell lung cancer (NSCLC) patients who are adequate for targeted treatment, a total of 137 NSCLC cases were analyzed by fluorescence in situ hybridization (FISH) for anaplastic lymphoma kinase (ALK) rearrangements, and Epidermal growth factor receptor (EGFR), kirsten rat sarcoma viral oncogene homolog (KRAS) mutations were evaluated by quantitative real-time PCR (qRT-PCR) platform combining amplification refractory mutation system (ARMS) primers and TaqMan probes.
An integrative analysis of gene expression and molecular interaction data to identify dys-regulated sub-networks in inflammatory bowel disease.
New
Simmons et al., Oxford, United Kingdom. In Bmc Bioinformatics, Dec 2015
CONCLUSIONS: We show that the selected subnetworks include genes and pathways of known relevance for IBD; in particular, the solutions found highlight cross-talk among enriched pathways, mainly the JAK/STAT signalling pathway and the EGF receptor signalling pathway.
The Most Common Cutaneous Side Effects of Epidermal Growth Factor Receptor Inhibitors and Their Management.
Review
New
Marinović et al., Zagreb, Croatia. In Acta Dermatovenerol Croat, Dec 2015
The use of epidermal growth factor receptor inhibitors (EGFRI) for the treatment of solid tumors is increasing due to elevated expression of epidermal growth factor receptors (EGFR) in the stimulation of tumor development.
ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
New
Haura et al., Kitakyūshū, Japan. In Plos One, Dec 2015
UNASSIGNED: Epithelial-mesenchymal transition (EMT) is one mechanism of acquired resistance to inhibitors of the epidermal growth factor receptor-tyrosine kinases (EGFR-TKIs) in non-small cell lung cancer (NSCLC).
Lapatinib in Combination With Capecitabine Plus Oxaliplatin in Human Epidermal Growth Factor Receptor 2-Positive Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma: TRIO-013/LOGiC- A Randomized Phase III Trial.
New
Impact
Slamon et al., Los Angeles, United States. In J Clin Oncol, Dec 2015
PURPOSE: To evaluate the efficacy of adding lapatinib to capecitabine and oxaliplatin (CapeOx) in patients with previously untreated human epidermal growth factor receptor 2 (HER2) -amplified advanced gastroesophageal adenocarcinoma.
Adjuvant Lapatinib and Trastuzumab for Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Results From the Randomized Phase III Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Trial.
New
Impact
Perez et al., Brussels, Belgium. In J Clin Oncol, Dec 2015
BACKGROUND: Lapatinib (L) plus trastuzumab (T) improves outcomes for metastatic human epidermal growth factor 2-positive breast cancer and increases the pathologic complete response in the neoadjuvant setting, but their role as adjuvant therapy remains uncertain.
Pan Canadian Rash Trial: A Randomized Phase III Trial Evaluating the Impact of a Prophylactic Skin Treatment Regimen on Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Induced Skin Toxicities in Patients With Metastatic Lung Cancer.
New
Impact
Laskin et al., Colombia. In J Clin Oncol, Dec 2015
PURPOSE: Erlotinib is an epidermal growth factor receptor inhibitor approved for patients with advanced non-small-cell lung cancer (NSCLC) whose epidermal growth factor receptor expression status is positive or unknown.
Circulating DNA in diagnosis and monitoring EGFR gene mutations in advanced non-small cell lung cancer.
Review
New
Tiseo et al., Parma, Italy. In Transl Lung Cancer Res, Oct 2015
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are current treatments for advanced non-small cell lung cancer (NSCLC) harboring activating EGFR gene mutations.
Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker.
Review
Dricu et al., Craiova, Romania. In Onco Targets Ther, 2014
Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 on chromosome 1 (ELTD1), an orphan adhesion G-protein coupled receptor, was reported as a regulator of angiogenesis, also involved in cancer progression and development.
Role of ErbB Receptors in Cancer Cell Migration and Invasion.
Review
Bennasroune et al., Reims, France. In Front Pharmacol, 2014
Recent findings indicate that ECM components such as matrikines bind specifically to EGF receptor and promote cell invasion.
Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research.
Review
Wang, Edmonton, Canada. In Int J Mol Sci, 2014
In this review, we focus on the transactivation of epidermal growth factor receptor (EGFR), a subfamily of RTKs, by GPCRs.
EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis.
GeneRIF
Xia et al., Shanghai, China. In Cell Prolif, 2012
EGF is essential to support proliferation of cancer stem cells that express higher levels of progenitor genes and lower levels of differential genes.
Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration.
GeneRIF
Buday et al., Budapest, Hungary. In J Biol Chem, 2012
Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration.
The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.
GeneRIF
Fu et al., San Diego, United States. In Mol Cell, 2012
By blocking individual branches in EGF signaling, we found that Akt activation plays a major role, while other branches, such as the JAK/STAT and ERK pathways, make minor contributions to EGF-induced splicing.
Epidermal growth factor cytoplasmic domain affects ErbB protein degradation by the lysosomal and ubiquitin-proteasome pathway in human cancer cells.
GeneRIF
Klonisch et al., Winnipeg, Canada. In Neoplasia, 2012
Epidermal growth factor cytoplasmic domain affects ErbB protein degradation by the lysosomal and ubiquitin-proteasome pathway in human cancer cells. The exon 23-encoded peptide region of EGFcyt was important for these biologic actions.
GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells.
GeneRIF
Lu et al., Nanjing, China. In Plos One, 2011
EGF Stimulates migration of HepG2 cells in vitro.
More papers using Epidermal Growth Factor antibodies
Activation of epidermal growth factor receptors in astrocytes: from development to neural injury.
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Deli Maria, In PLoS ONE, 2006
... v∶v, supplemented with 2.5% fetal bovine serum (FBS, Life Technologies), 2.5 ng/ml epidermal growth factor (EGF, Life Technologies), 25 µg/ml bovine pituitary ...
Biological fate and clinical implications of arginine metabolism in tissue healing.
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Agarwal Sudha, In PLoS ONE, 2005
... Human epidermal growth factor (EGF) was obtained from Collaborative Biomedical Products (Bedford, MA) ...
Preparation of organotypic hippocampal slice cultures: interface method
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Lu Xin-Yun, In PLoS ONE, 2005
... Finally, cells were washed and resuspended in culture media supplemented with FGF-2 (R&D Systems) and EGF (Merck), both at 20 ng/ml ...
Effect of Tetrandrine on LPS-induced NF-κB activation in isolated pancreatic acinar cells of rat
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Wu Guoyao et al., In Amino Acids, 2005
... Epidermal growth factor was obtained from BD Biosciences (Bedford, MA, USA), and ...
Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein
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Robinson Margaret S et al., In Traffic (Copenhagen, Denmark), 2004
CALM, auxilin 2, dynamin 2, CD8, transferrin receptor and EGF receptor were purchased from Santa Cruz, BD Biosciences, Serotec, Sigma-Aldrich, Santa Cruz, ...
Frequent p16INK4a promoter hypermethylation in human papillomavirus-infected female lung cancer in Taiwan
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Waalkes Michael P. et al., In Environmental Health Perspectives, 2004
... Keratinocyte serum-free medium (K-SFM), epidermal growth factor (EGF), bovine pituitary extract (BPE), 100 X antibiotic–antimycotic mixture, and TRIzol reagent were purchased from Life Technologies, Inc ...
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
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Schneider Guenter, In PLoS ONE, 2003
... chloroquine (Sigma-Aldrich, St Louis, MO), Z-VAD-fmk (R&D Systems, MN, USA), cycloheximide (Sigma-Aldrich), epidermal growth factor (EGF; Daewoong Pharmaceuticals, Korea), and cetuximab (Merck Korea) ...
Thrombin Up-regulates Tissue Factor Pathway Inhibitor-2 Synthesis through a Cyclooxygenase-2-dependent, Epidermal Growth Factor Receptor-independent Mechanism
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Rosenbaum Jean et al., In Comparative Hepatology, 2003
... Culture medium and additives, recombinant human epidermal growth factor (EGF) and Moloney Murine Leukemia Virus reverse transcriptase were from Gibco-BRL (Life Technologies, Cergy-Pontoise, France) ...
At the acidic edge: emerging functions for lysosomal membrane proteins.
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Butterworth Michael, In PLoS ONE, 2002
... (FCS), 1% insulin-transferrin-selenium (ITS), 16 mmol/L HEPES (all PAN-Biotech, Germany) and 5 ng/mL epidermal growth factor (EGF; BD Biosciences, Germany) and incubated at ...
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover
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Katz Elad, In PLoS ONE, 2002
... Louis, MO) and 5 ng/ml EGF (Cell Signaling Technologies; Pickerington, ON) ...
Theanine, gamma-glutamylethylamide, is metabolized by renal phosphate-independent glutaminase
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Renping Zhou, In PLoS ONE, 2002
... Epidermal growth factor (EGF) was provided by Biomedical Technologies (Stoughton, MA, USA) ...
The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-gamma-mediated inhibition in human chondrocytes: requirement for Stat1 alpha, Jak1 and Jak2
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Bernier Suzanne M et al., In Arthritis Research & Therapy, 2002
... Primary chondrocyte cultures were treated with TNF-α (30 ng/ml; Sigma Aldrich, Oakville, ON, Canada), with EGF (10 ng/ml; Sigma Aldrich) or with vehicle (phosphate-buffered ...
Induction of p38 mitogen-activated protein kinase reduces early endosome autoantigen 1 (EEA1) recruitment to phagosomal membranes
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Puertollano Rosa et al., In Traffic (Copenhagen, Denmark), 2002
... Placid, NY, USA), rabbit anti-GFP (MBL International, Woburn, MA, USA), mouse monoclonal and rat monoclonal anti-EGF receptor (ab3103 and ICR10; Abcam, Cambridge, MA, USA) ...
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
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Katoh Masaru, In PLoS ONE, 2002
... Bradykinin and 12-phorbol 13-myristate acetate (PMA) were from Sigma, EGF (epidermal growth factor) from PeproTech (Rocky Hill, NJ) and CID755673 (2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one) from Tocris Bioscience (Ellisville, MO) ...
Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF
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Higashiyama Shigeki et al., In The Journal of Cell Biology, 2001
... A plasmid for recombinant expression of YFP-tagged proHB-EGF was generated by subcloning the human HB-EGF cDNA with the stop codon deleted into pEYFP-N1 (CLONTECH Laboratories, Inc.) ...
Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells
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Waalkes Michael P. et al., In Environmental Health Perspectives, 2001
... Louis, MO) and keratinocyte serum-free medium (K-SFM), EGF, bovine pituitary extract (BPE), 100× antibiotic-antimycotic mixture, and TRIzol reagent from Life Technologies, Inc ...
Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model
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Rosen Jeffrey M. et al., In The Journal of Cell Biology, 2001
... -glutamine (JRH Biosciences), 10 ng/ml EGF (Life Technologies), 5 μg/ml insulin (Sigma-Aldrich), and ...
Widely used prostate carcinoma cell lines share common origins.
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Leri Annarosa, In PLoS ONE, 2000
... K-SFM and supplements (BPE and EGF) were purchased from Gibco, USA, while RPMI 1640 and FBS were obtained from Invitrogen Life Technologies, USA. ...
Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension
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Nowak Dorota et al., In Histochemistry and Cell Biology, 1999
... Matrigel™ and EGF were obtained from BD Biosciences (USA) ...
Inducible dimerization of FGFR1
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Rosen Jeffrey M. et al., In The Journal of Cell Biology, 1999
... EGF (Life Technologies), 5 μg ml ...
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
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Madshus Inger H. et al., In The Journal of Cell Biology, 1998
... Human recombinant EGF was from Bachem Feinchemikalien AG, human recombinant ...
Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase
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Götz Jürgen, In PLoS ONE, 1997
... Polyclonal goat anti-CcOX1 and goat anti-EGF antibodies were from Santa Cruz Biotechnology, CA, USA ...
EGF receptor regulation of cell motilityEGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway
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Mercurio Arthur M. et al., In The Journal of Cell Biology, 1997
... A rabbit polyclonal antibody specific for the EGF receptor was purchased from Santa Cruz Biotechnology.
EGF receptor regulation of cell motilityEGF induces disassembly of focal adhesions independently of the motility-associated PLC γ signaling pathway
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Wells Alan et al., In The Journal of Cell Biology, 1997
... EGF was obtained from Collaborative Biomedical Products ...
Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal.
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Creighton Chad, In PLoS ONE, 1995
... induce EMT, MDA-MB-468 cells were deprived of serum (0.5% FCS) for 24 h and stimulated with EGF (50 ng/mL; Sigma Aldrich) as previously described ...
Cigarette smoking and protection from Parkinson's disease: false association or etiologic clue
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Strack Stefan, In PLoS ONE, 1994
... Epidermal growth factor (EGF) was provided by Biomedical Technologies (Stoughton, MA, USA) ...
Expression of c-erb B-2/neu proto-oncogene in human prostatic cancer tissues and cell lines
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Waalkes Michael P. et al., In Environmental Health Perspectives, 1991
... Louis, MO), and keratinocyte serum-free medium (K-SFM), epidermal growth factor (EGF), bovine pituitary extract (BPE), 100 X antibiotic-antimycotic mixture, and TRIzol Reagent from Life Technologies, Inc ...
Differing effects of apical and basolateral adenosine on colonic epithelial cell line T84.
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Launikonis Bradley, In PLoS ONE, 1988
... (FCS), 1% insulin-transferrin-selenium (ITS), 16 mM HEPES (all PAN-Biotech, Germany) and 5 ng/mL epidermal growth factor (EGF; BD Biosciences, Germany) incubated at an ...
Production of monoclonal antibodies with specificity for different epitopes on the human epidermal growth factor molecule
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Coffey Robert J. et al., In The Journal of Cell Biology, 1987
... Recombinant human EGF was purchased from Collaborative Biomedical Products (Bedford, MA) ...
Measurement and characterization of free radical generation in reoxygenated human endothelial cells
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Marikovsky M, In British Journal of Cancer, 1987
... Mouse epidermal growth factor (EGF) was purchased from Collaborative Biomedical Products (Bedford, MA, USA) ...
Nerve growth factors on human melanoma cells in culture
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Nadler Timothy et al., In International Journal of Proteomics, 1976
... Following synchronization, cells were exposed to 100 ng/mL human EGF (Cell Signaling Technology, Danvers, MA) for ...
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