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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ephrin-B1

Ephrin-B1, ephrin-B, EFNB1
The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Eph, Ephrin-B2, CAN, V1a, EphB3
Papers using Ephrin-B1 antibodies
Regulation of neural progenitor cell state by ephrin-B
Supplier
Lu Qiang et al., In The Journal of Cell Biology, 2005
... Primary antibodies used in this study included a rabbit polyclonal anti–ephrin-B antibody C18 (1:100; Santa Cruz Biotechnology, Inc.), anti–PDZ-RGS3 (described in ...
Papers on Ephrin-B1
Differential expression of neurogenes among breast cancer subtypes identifies high risk patients.
New
Gascón et al., Barcelona, Spain. In Oncotarget, Jan 2016
Histamine receptor1 (HRH1), neuropilin2 (NRP2), ephrin-B1 (EFNB1), neural growth factor receptor (NGFR) and amyloid precursor protein (APP) were differentially overexpressed in basal and HER2-enriched tumor samples and syntaxin 1A (STX1A) was overexpressed in HER2-enriched and luminal B tumors.
Visual Pathways in Humans With Ephrin-B1 Deficiency Associated With the Cranio-Fronto-Nasal Syndrome.
New
Wieland et al., Magdeburg, Germany. In Invest Ophthalmol Vis Sci, Dec 2015
Here, we examined the visual system in humans with ephrin-B1 deficiency, which is x-linked and associated with the cranio-fronto-nasal syndrome (CFNS) in heterozygous females.
EphB/ephrinB signaling in cell adhesion and migration.
Review
New
Lee et al., Taegu, South Korea. In Mol Cells, Mar 2015
In this review, we present an in-depth overview of the structure, mechanisms, cell signaling, and functions of EphB/ephrinB in cell adhesion and migration.
Histone Deacetylase Inhibitors Antagonize Distinct Pathways to Suppress Tumorigenesis of Embryonal Rhabdomyosarcoma.
Chen et al., Seattle, United States. In Plos One, 2014
By gain-of-function, loss-of-function, and chromatin immunoprecipitation (ChIP) studies, we show that Notch1- and EphrinB1-mediated pathways are regulated by HDACs to inhibit differentiation and enhance migratory capacity of ERMS cells, respectively.
Activation of EphA4 and EphB2 Reverse Signaling Restores the Age-Associated Reduction of Self-Renewal, Migration, and Actin Turnover in Human Tendon Stem/Progenitor Cells.
Docheva et al., München, Germany. In Front Aging Neurosci, 2014
Here, we report for the first time the significant downregulation of the ephrin receptors EphA4, EphB2 and B4 and ligands EFNB1 in aged-TSPC (A-TSPC).
Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons.
Cramer et al., Orange, United States. In Neural Dev, 2014
Ephrin-A signaling plays a similar role to ephrin-B signaling in the VCN-MNTB pathway, where both classes normally prevent formation of calyceal projections to ipsilateral MNTB.
Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules.
Review
Kawachi et al., Niigata, Japan. In World J Nephrol, 2014
Then we have found that synaptic vesicle protein 2B, ephrin-B1 and neurexin were already downregulated at the early stage of puromycin aminonucleoside nephropathy, and that these molecules were localized close to nephrin.
Multivalent ligands control stem cell behaviour in vitro and in vivo.
Impact
Schaffer et al., Berkeley, United States. In Nat Nanotechnol, 2013
We also found that synthetic multivalent conjugates of ephrin-B1 strongly enhance human embryonic and induced pluripotent stem cell differentiation into functional dopaminergic neurons.
Genetic causes of syndromic craniosynostoses.
Review
Krajewska-Walasek et al., Warsaw, Poland. In Eur J Paediatr Neurol, 2013
Many of this disorders are caused by mutations in the fibroblast growth factor receptor genes: FGFR2, FGFR3 (encoding fibroblast growth factor receptors), TWIST1 (functions as an upstream regulator of FGFRs) and EFNB1 (gene encoding fibrillin1).
Cy5.5-Anti-ephrin receptor B4 (EphB4) humanized monoclonal antibody hAb47
Review
Leung, Bethesda, United States. In Unknown Journal, 2013
On the basis of their structures and sequence relationships, ephrins are divided into two classes: the ephrin-A class, Ephs that are anchored to the cell membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, Ephs that are transmembrane proteins.
Rhomboid proteins: a role in keratinocyte proliferation and cancer.
Review
Blaydon et al., London, United Kingdom. In Cell Tissue Res, 2013
Other substrates of RHBDL2 include members of the EphrinB family and thrombomodulin.
Possible role of Efnb1 protein, a ligand of Eph receptor tyrosine kinases, in modulating blood pressure.
GeneRIF
Wu et al., Montréal, Canada. In J Biol Chem, 2012
Results show that Efnb1 is a negative regulator of smooth muscle cell (VSMC)contractility and blood pressure (BP).
Ephrin-B1 is a novel specific component of the lateral membrane of the cardiomyocyte and is essential for the stability of cardiac tissue architecture cohesion.
GeneRIF
Galés et al., Toulouse, France. In Circ Res, 2012
Ephrin-B1 is necessary for cardiac tissue architecture cohesion by stabilizing the adult cardiomyocytes morphology through regulation of its lateral membrane.
ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers.
GeneRIF
Lee et al., Sioux Falls, United States. In Plos One, 2011
Data show that EphrinB1, a PTPN13 substrate, interacts with ErbB2, and Src kinase mediates EphrinB1 phosphorylation and subsequent MAP Kinase signaling.
Targeted disruption of ephrin B1 in cells of myeloid lineage increases osteoclast differentiation and bone resorption in mice.
GeneRIF
Xing et al., Loma Linda, United States. In Plos One, 2011
myeloid lineage produced ephrin B1 is a negative regulator of bone resorption
Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling.
Impact
Batlle et al., Barcelona, Spain. In Nat Cell Biol, 2011
We show that EphB/ephrin-B signalling in epithelial cells regulates the formation of E-cadherin-based adhesions.
The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
GeneRIF
Luo et al., Montréal, Canada. In Bmc Immunol, 2010
the function of EFNB1 in the T cell compartment could be compensated by other members of the EFN family, and that such redundancy safeguards the pivotal roles of EFNB1 in T cell development and function.
EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.
Impact
Greenberg et al., Boston, United States. In Cell, 2010
We have identified a RhoA guanine nucleotide exchange factor, Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding to the EphB receptor tyrosine kinase triggers Ephexin5 phosphorylation, ubiquitination, and degradation.
EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting.
Impact
Lloyd et al., London, United Kingdom. In Cell, 2010
Upon nerve cut, ephrin-B/EphB2 signaling between fibroblasts and Schwann cells results in cell sorting, followed by directional collective cell migration of Schwann cells out of the nerve stumps to guide regrowing axons across the wound.
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells.
Impact
Pawson et al., Toronto, Canada. In Science, 2010
We implemented a proteomic strategy to systematically determine cell-specific signaling networks underlying EphB2- and ephrin-B1-controlled cell sorting.
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