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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Ephrin-A4, EFNA4
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Eph, EphA2, CAN, Ephrin-A1, SEK
Papers on Ephrin-A4
Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions.
Dylla et al., San Francisco, United States. In Clin Cancer Res, Oct 2015
Gene expression analysis of TIC led to the identification of Ephrin-A4 (EFNA4) as a prospective therapeutic target.
Connexin 43 stabilizes astrocytes in a stroke-like milieu to facilitate neuronal recovery.
Feng et al., Shanghai, China. In Acta Pharmacol Sin, Aug 2015
The expression of Cx43 and Ephrin-A4 in astrocytes was detected using immunocytochemical staining and Western blot assays.
EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.
Wang et al., Cleveland, United States. In Oncogene, Mar 2015
To test whether ephrin-As in tumor microenvironment can regulate GSC invasion, the newly established Efna1;Efna3;Efna4 triple knockout mice (TKO) were used in an ex vivo brain slice invasion assay.
EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma.
MacDonald et al., Atlanta, United States. In J Neurooncol, 2015
We found EPHB4 and EFNA4 almost exclusively expressed by SHH MB, whereas EPHA2, EPHA8, EFNA1 and EFNA3 are predominantly expressed by non-SHH MB.
A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.
Aparicio et al., Vancouver, Canada. In Breast Cancer Res, 2014
Several genes, including PROCR and the neuronal pathfinding molecules EFNA4 and NTN1, were also required for proper differentiation and polarization in three-dimensional cultures.
Ephrin-A3 and ephrin-A4 contribute to microglia-induced angiogenesis in brain endothelial cells.
Chen et al., Shenyang, China. In Anat Rec (hoboken), 2014
The expression of angiogenic factors, ephrin-A3 and ephrin-A4, were specifically upregulated in BMECs exposed to BV2-derived culture supernatant.
Detection of cadherin-17 in human colon cancer LIM1215 cell secretome and tumour xenograft-derived interstitial fluid and plasma.
Simpson et al., Melbourne, Australia. In Biochim Biophys Acta, 2013
Many of the glycoproteins identified in this study (e.g., AREG, DSG2, EFNA1, EFNA3, EFNA4, EPHB4, ST14, and TIMP1) have been reported to be implicated in CRC biology.
Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion.
Konishi et al., Kyoto, Japan. In Int J Gynecol Cancer, 2013
The effects of recombinant human Eph A1 (r-Eph A1) and r-ephrin A4 on the proliferation and invasion of JEG-3 cells were investigated by cell proliferation and Matrigel invasion assays.
Eph-2B, acting as an extracellular ligand, induces differentiation markers in epidermal keratinocytes.
Blumenberg et al., New York City, United States. In J Cell Physiol, 2012
We compared the EphB2 and EFNA4 effects during a 48 h time course, using transcriptional profiling.
Ephrin-a4 is involved in retinal neovascularization by regulating the VEGF signaling pathway.
Li et al., Beijing, China. In Invest Ophthalmol Vis Sci, 2012
ephrin-A4 plays an important role in retinal NV and is a potential target against retinal NV. The proangiogenic function of ephrin-A4 may be linked to its crucial role in the VEGF signaling pathway.
[Inhibitory effect of chondroitinase ABC on ephrin A4 expression after spinal cord injury in rats].
Sun et al., Luohe, China. In Sheng Li Xue Bao, 2012
The aim of the study was to investigate the effect of chondroitinase ABC (ChABC) on ephrin A4 (EphA4) expression after spinal cord impairment (SCI) in rats.
The platelet P2Y12 receptor contributes to granule secretion through Ephrin A4 receptor.
Akkerman et al., Utrecht, Netherlands. In Platelets, 2011
The main responses of P2Y(1) ligation are platelet shape change and transient aggregation while P2Y(12) ligation amplifies P2Y(1)-induced aggregation and accelerates aggregation, secretion and thromboxane A(2) production induced by other agonist-receptor complexes.
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.
Koenig et al., Watertown, United States. In Mol Neurodegener, 2011
EVP-0015962 did not cause the accumulation of other γ-secretase substrates, such as the Notch and ephrin A4 receptors, whereas a γ-secretase inhibitor reduced processing of both.
The mouse IAPE endogenous retrovirus can infect cells through any of the five GPI-anchored Ephrin A proteins.
Heidmann et al., Villejuif, France. In Plos Pathog, 2011
We identified Ephrin A4, a GPI-anchored molecule involved in several developmental processes, as a receptor for the IAPE pseudotypes.
Specific and shared targets of ephrin A signaling in epidermal keratinocytes.
Blumenberg et al., New York City, United States. In J Biol Chem, 2011
However, although the responses to EFNA3, EFNA4, and EFNA5 are identical, the responses to EFNA1 and EFNA2 are characteristic and distinctive.
Ephrins guide migrating cortical interneurons in the basal telencephalon.
Bolz et al., Jena, Germany. In Cell Adh Migr, 2010
Downregulation of the EphA4 receptor via siRNA transfection reduced the repulsive effect of ephrin-A3, indicating that EphA4 mediates at least in part the repulsive effect of ephrin-A3.
Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome.
Abdallaha et al., Egypt. In Indian J Cancer, 2010
The cytoplasmic pattern of ephrin A4 could identify a subgroup of primary osteosarcoma patients with a high liability for progression, poor prognosis, and inferior response to chemotherapy.
An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression.
Alonso-Colmenar et al., Madrid, Spain. In Blood, 2010
EFNA4-EphA2 interactions are involved in Chronic lymphocytic leukemia cell trafficking between blood and the tissues
Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells.
Zapata et al., Madrid, Spain. In Leuk Res, 2009
CLL B-cells showed a more heterogeneous Eph/EFN profile, specially EFNA4, EphB6 and EphA10. EphB6 and EFNA4 were further related with the clinical course of CLL.
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