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EPH receptor B4

EphB4
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ephrin-B2, Eph, CAN, Ephrin-B1, V1a
Papers using EphB4 antibodies
The New S Language: A Programming Environment for Data Analysis and Graphics;
Supplier
Zhang Lin, In PLoS ONE, 1997
... (Abgent; BP7612b); rabbit EphA8 (Abnova, PAB3015); rabbit anti-ephrin-A1 (Amgen/Immunex, Thousand Oaks, CA; clone P2); rabbit anti-EphB4 (Abgent; clone RB14731) and synthetic ...
Yeast surface display for screening combinatorial polypeptide libraries.
Supplier
Chin Wei-Chun, In PLoS ONE, 1996
... followed by goat phycoerythrin-conjugated anti-mouse antibody (Santa Cruz Biotechnology), as well as by recombinant human EphB4-Fc chimera (Biomiga) followed by goat phycoerythrin-conjugated anti-human antibody (Santa Cruz Biotechnology).
Papers on EphB4
Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice.
New
Liu et al., Xi'an, China. In Int J Mol Med, Feb 2016
These results demonstrate that bradykinin receptors and the EphB4/EphrinB2 pathway mediate the development of complications in mice with diabetes-related osteoporosis and suggest that the inactivation of bradykinin receptors and the EphB4/EphrinB2 pathway enhance the severity of complications in mice with diabetes-related osteoporosis.
Fetal liver hematopoietic stem cell niches associate with portal vessels.
New
Impact
Frenette et al., United States. In Science, Feb 2016
After closure of the umbilical inlet at birth, portal vessels undergo a transition from Neuropilin-1(+)Ephrin-B2(+) artery to EphB4(+) vein phenotype, associated with a loss of periportal Nestin(+)NG2(+) cells and emigration of HSCs away from portal vessels.
Shear stress, arterial identity and atherosclerosis.
New
Jones et al., Montréal, Canada. In Thromb Haemost, Jan 2016
Notch1/4, Notch ligand delta-like 4 (Dll4), and Notch downstream effectors are typically expressed in arterial cells along with EphrinB2, whereas chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and EphB4 characterise vein endothelial cells.
BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy.
New
Chemtob et al., Montréal, Canada. In Invest Ophthalmol Vis Sci, Jan 2016
Retinal expression of VEGF, Delta-like ligand 4 (Dll4), Netrin-1, Ephrin-B2, and EphB4 was analyzed by quantitative PCR and Western blot analysis.
Stimulation of vasculogenesis and leukopoiesis of embryonic stem cells by extracellular transfer RNA and ribosomal RNA.
New
Sauer et al., Gießen, Germany. In Free Radic Biol Med, Dec 2015
ex-tRNA was taken up by endosomes, increased expression of the pro-angiogenic semaphorin B4 receptor plexin B1 as well as the ephrin-type B receptor 4 (EphB4) and ephrinB2 ligand and enhanced cell migration, which was inhibited by the VEGFR2 antagonist SU5614 and the PI3K inhibitor LY294002.
Periostin: A Downstream Mediator of EphB4-Induced Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.
New
Dai et al., Chongqing, China. In Stem Cells Int, Dec 2015
Erythropoietin-producing hepatocyte B4 (EphB4) has been reported to be a key molecular switch in the regulation of bone homeostasis, but the underlying mechanism remains poorly understood.
Erythropoietin Stimulates Tumor Growth via EphB4.
New
Impact
Sood et al., Houston, United States. In Cancer Cell, Dec 2015
Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor growth and progression.
Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics.
Review
Garayoa et al., Salamanca, Spain. In World J Stem Cells, 2014
Importantly, pMSCs also readily contribute to MBD by promoting OC formation and activity at various levels (i.e., increasing RANKL to OPG expression, augmenting secretion of activin A, uncoupling ephrinB2-EphB4 signaling, and through augmented production of Wnt5a), thus further contributing to OB/OC uncoupling in osteolytic lesions.
Talking among ourselves: paracrine control of bone formation within the osteoblast lineage.
Review
Sims et al., Australia. In Calcif Tissue Int, 2014
We provide four snapshots of communication pathways that exist within the osteoblast lineage between different stages of their differentiation, as follows: (1) PTHrP, a factor produced by early osteoblasts that stimulates the activity of more mature bone-forming cells and the most mature osteoblast embedded within the bone matrix, the osteocyte; (2) sclerostin, a secreted factor, released by osteocytes into their extensive communication network to restrict the activity of younger osteoblasts on the bone surface; (3) oncostatin M, a member of the IL-6/gp130 family of cytokines, expressed throughout osteoblast differentiation and acting to stimulate osteoblast activity that works on a different receptor in the mature osteocyte compared to the preosteoblast; and (4) Eph/ephrins, cell-contact-dependent kinases, and the osteoblast-lineage-specific interaction of EphB4 and ephrinB2, which provides a checkpoint for entry to the late stages of osteoblast differentiation and restricts RANKL expression.
Regulation of signaling interactions and receptor endocytosis in growing blood vessels.
Review
Adams et al., Münster, Germany. In Cell Adh Migr, 2013
During growth and tissue regeneration but also in many pathological settings, these vascular networks expand, which is critically controlled by the receptor EphB4 and the ligand ephrin-B2.
[Effects of bidirectional EphB4-EphrinB2 signaling on bone remodeling].
Review
Bao et al., Nanjing, China. In Zhongguo Gu Shang, 2013
EphrinB2 is expressed on osteoblasts and EphB4 is expressed on osteoclasts.
Cy5.5-Anti-ephrin receptor B4 (EphB4) humanized monoclonal antibody hAb47
Review
Leung, Bethesda, United States. In Unknown Journal, 2013
Eph-2 is expressed on arterial and activated endothelial cells, whereas EphB4 is normally expressed on venous endothelial cells and various blood cells (8).
EphB4 gene polymorphism and protein expression in non-small-cell lung cancer.
GeneRIF
Chen et al., Wuxi, China. In Mol Med Report, 2012
EphB4 protein expression is significantly increased in non-small- cell lung cancer and corresponds to progression and severity of the disease.
Relationships among differentiation degree, contrast-enhanced ultrasound and the expression of Ephb4/Ephrinb2 in primary hepatocarcinoma.
GeneRIF
Zhang et al., Tianjin, China. In Hepatogastroenterology, 2012
EphB4/EphrinB2 expression has closed related to gennesis and progression of hepatoblastoma.
Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients.
GeneRIF
Deng et al., Xi'an, China. In Clin Transl Oncol, 2012
Data indicated for the first time that EphrinB2 and EphB4 expressions increase according to the histopathological grade and KPS score of glioma, and their expression levels are related to the progression-free survival of glioblastoma patients.
[Relationship between multi-slice spiral CT pulmonary perfusion imaging and the expression of EphB4 and ephrinB2 in non-small cell lung cancer].
GeneRIF
Chen et al., Changsha, China. In Zhonghua Zhong Liu Za Zhi, 2011
The expressions of ephrinB2 and EphB4 were significantly higher in NSCLC tissue than in control tissues, and were positively correlated with lymphatic metastasis.
Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.
GeneRIF
Chen et al., Nashville, United States. In Plos One, 2010
Data found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets.
Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells.
Impact
Nobes et al., Bristol, United Kingdom. In Nat Cell Biol, 2010
The unimpeded migration of metastatic PC-3 cells towards fibroblasts is dependent on activation of EphB3 and EphB4 by ephrin-B2, which we show activates Cdc42 and cell migration.
Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation.
Impact
GeneRIF
Stainier et al., San Francisco, United States. In Science, 2009
first embryonic vein formed by selective sprouting of progenitor cells from precursor vessel, followed by vessel segregation; these processes were regulated by EphrinB2 & EphB4 which are expressed in arterial-fated & venous-fated progenitors respectively
Boning up on ephrin signaling.
Review
Impact
Elefteriou et al., Nashville, United States. In Cell, 2006
Zhao et al. (2006) now demonstrate bidirectional signaling between these two cell populations via the transmembrane ligand ephrinB2 expressed by osteoclasts and its receptor EphB4 expressed by osteoblasts.
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