EphB2 and EphB3 play an important role in the lymphoid seeding of murine adult thymus.
Madrid, Spain. In J Leukoc Biol, Dec 2015
Adult thymuses lacking either ephrin type B receptor 2 (EphB2) or EphB3, or expressing a truncated form of EphB2, the forward signal-deficient EphB2LacZ, have low numbers of early thymic progenitors (ETPs) and are colonized in vivo by reduced numbers of injected bone marrow (BM) lineage-negative (Lin(-)) cells.
Eph/Ephrin-mediated interactions in the thymus.
Madrid, Spain. In Neuroimmunomodulation, 2010
In addition, EphB2 and EphB3 play a cell-autonomous role in regulating the transitions of double-negative to double-positive cells and of double-positive to single-positive thymocytes and the lack of these molecules or their ligands ephrin B1 and ephrin B2 induces profound alterations of the TEC maturation and in the arrangement of epithelial network.
Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions.
Cambridge, United States. In Curr Pharm Des, 2008
JNK3, p38 MAPK, ERK, PKC, ROCKII, GSK3, Cdk5, MLK, EphB3 kinase, RIP1 kinase, LRRK2, TTBK1, ASK1, CK, DAPK, and PKN1) that could serve as potential therapeutic targets for these maladies are reviewed.