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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

EPH receptor B3

EphB3, HEK2
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Eph, Ephrin-B1, Ephrin-B2, EphB4, Ephrin-B3
Papers on EphB3
EphB2 and EphB3 play an important role in the lymphoid seeding of murine adult thymus.
New
Zapata et al., Madrid, Spain. In J Leukoc Biol, Dec 2015
Adult thymuses lacking either ephrin type B receptor 2 (EphB2) or EphB3, or expressing a truncated form of EphB2, the forward signal-deficient EphB2LacZ, have low numbers of early thymic progenitors (ETPs) and are colonized in vivo by reduced numbers of injected bone marrow (BM) lineage-negative (Lin(-)) cells.
Ephrins and Ephs in cochlear innervation and implications for advancing cochlear implant function.
New
Henkemeyer et al., Dallas, United States. In Laryngoscope, May 2015
Knockout mice with null function of EphB1, EphB2, and EphB3 demonstrated abnormal inner ear innervation and elevated ABR thresholds, indicating hearing loss.
EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury.
Liebl et al., Miami, United States. In Cell Death Dis, 2014
We demonstrate that EphB3 receptors mediate oligodendrocyte (OL) cell death in the injured spinal cord through dependence receptor mechanism.
Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation.
Lamb et al., Atlanta, United States. In Plos One, 2014
This result may have arisen because DCs express other members of the EphB receptor family, EphB3, EphB4 and EphB6, all of which can interact with ephrin B ligands, or because EphB2 may be playing a role in another aspect of DC biology such as migration.
[Ephrin B2 is involved in Porphyromonas gingivalis infection-enhanced adhesion of THP-1 to human umbilical vein endothelial cells].
Li et al., Nanjing, China. In Zhonghua Kou Qiang Yi Xue Za Zhi, 2014
The mRNA levels of Ephrin B2 receptors, including EphB3 (5.169±0.152,
EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.
GeneRIF
Freywald et al., Regina, Canada. In J Immunol, 2012
Our work shows that EphB3 is consistently expressed by malignant T lymphocytes, most frequently in combination with EphB6, and that stimulation with their common ligands strongly suppresses Fas-induced apoptosis in these cells.
EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.
GeneRIF
Xie et al., Shanghai, China. In Nat Commun, 2011
EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex
Roles of homeobox genes in retinal ganglion cell differentiation and axonal guidance.
Review
Eisenstat et al., Winnipeg, Canada. In Adv Exp Med Biol, 2011
Examples of this are the repression of EphB1 by Isl2, and Vax1/Vax2 regulation of EphB2/EphB3 expression.
RNA-binding protein Khd1 and Ccr4 deadenylase play overlapping roles in the cell wall integrity pathway in Saccharomyces cerevisiae.
GeneRIF
Irie et al., Tsukuba, Japan. In Eukaryot Cell, 2011
Khd1 and Ccr4 modulate a signal from Rho1 in the cell wall by regulating the expression of RhoGEF and RhoGAP.
Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling.
Impact
GeneRIF
Batlle et al., Barcelona, Spain. In Nat Cell Biol, 2011
Data show that EphB receptors interact with E-cadherin and with the metalloproteinase ADAM10 at sites of adhesion.
Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex.
GeneRIF
Cramer et al., Irvine, United States. In Plos One, 2010
These results demonstrate that EphB receptors influence auditory cortical responses, and suggest that EphB signaling has multiple functions in auditory system development.
Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells.
Impact
Nobes et al., Bristol, United Kingdom. In Nat Cell Biol, 2010
The unimpeded migration of metastatic PC-3 cells towards fibroblasts is dependent on activation of EphB3 and EphB4 by ephrin-B2, which we show activates Cdc42 and cell migration.
Eph/Ephrin-mediated interactions in the thymus.
Review
Zapata et al., Madrid, Spain. In Neuroimmunomodulation, 2010
In addition, EphB2 and EphB3 play a cell-autonomous role in regulating the transitions of double-negative to double-positive cells and of double-positive to single-positive thymocytes and the lack of these molecules or their ligands ephrin B1 and ephrin B2 induces profound alterations of the TEC maturation and in the arrangement of epithelial network.
The role of Eph receptors and ephrin ligands in colorectal cancer.
Review
Boyd et al., Australia. In Int J Cancer, 2010
EphB and ephrin B proteins have been implicated in the homeostasis of the gastrointestinal tract where EphB2- and EphB3-ephrin B signaling regulates cell sorting in the mature epithelium.
Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions.
Review
Cuny, Cambridge, United States. In Curr Pharm Des, 2008
JNK3, p38 MAPK, ERK, PKC, ROCKII, GSK3, Cdk5, MLK, EphB3 kinase, RIP1 kinase, LRRK2, TTBK1, ASK1, CK, DAPK, and PKN1) that could serve as potential therapeutic targets for these maladies are reviewed.
EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells.
Impact
Batlle et al., Barcelona, Spain. In Nat Genet, 2007
The genes encoding tyrosine kinase receptors EphB2 and EphB3 are beta-catenin and Tcf4 target genes in colorectal cancer (CRC) and in normal intestinal cells.
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.
Impact
Clevers et al., Utrecht, Netherlands. In Cell, 2002
We show here that beta-catenin and TCF inversely control the expression of the EphB2/EphB3 receptors and their ligand ephrin-B1 in colorectal cancer and along the crypt-villus axis.
Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk.
Impact
Stacker et al., Melbourne, Australia. In Nat Genet, 2000
Gene targeting has identified components of cytokine/growth factor signalling systems such as Tgf-alpha/Egfr, Eph receptors B2 and B3 (Ephb2 and Ephb3, respectively), Tgf-beta2, Tgf-beta3 and activin-betaA (ref.
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