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Eph receptor A7

EphA7, MDK1
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Eph, SEK, EphA3, CAN, ALI
Papers using EphA7 antibodies
The New S Language: A Programming Environment for Data Analysis and Graphics;
Supplier
Zhang Lin, In PLoS ONE, 1997
... clone 347400); rabbit anti-EphA4 (Lifespan Biosciences, Seattle, WA; clone LS-A2482; Abnova, Walnut, CA; PAB3007); rabbit anti-EphA7 (Abgent, San Diego, CA; clone ...
Papers on EphA7
Regional expression and ultrastructural localization of EphA7 in the hippocampus and cerebellum of adult rat.
New
Doucet et al., Montréal, Canada. In J Comp Neurol, Feb 2016
UNASSIGNED: EphA7 is expressed in the adult CNS, where its roles are yet poorly defined.
High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.
New
Sepulveda et al., New York City, United States. In Mod Pathol, Feb 2016
Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN).
Identification of the 187 bp EphA7 Genomic DNA as the Dorsal Midline-Specific Enhancer of the Diencephalon and Mesencephalon.
New
Park et al., Seoul, South Korea. In Mol Cells, Dec 2015
EphA7 is a key molecule in regulating the development of the dien- and mesencephalon.
EphA4 Has Distinct Functionality From EphA7 in the Corticothalamic System During Mouse Brain Development.
New
Torii et al., Los Angeles, United States. In J Comp Neurol, Dec 2015
Here, we show that a receptor of the EphA subfamily, EphA4, has distinct effects from its close relative EphA7 in the developing brain.
Secreted Ephrin Receptor A7 Promotes Somatic Cell Reprogramming by Inducing ERK Activity Reduction.
New
Nishida et al., Kyoto, Japan. In Stem Cell Reports, Nov 2015
Here we identify a truncated form of ephrin receptor A7 (EPHA7) as a key regulator of reprogramming.
Effects of altered ephrin-A5 and EphA4/EphA7 expression on tumor growth in a medulloblastoma mouse model.
Karam et al., Aurora, United States. In J Hematol Oncol, 2014
Previous studies have suggested a role for the ephrin-A5 ligand and its receptors, EphA4 and EphA7, in granule cell-precursor formation and in guiding cell migration.
Analysis of microarray-identified genes and microRNAs associated with drug resistance in ovarian cancer.
Li et al., Nanning, China. In Int J Clin Exp Pathol, 2014
Nine microRNAs (microRNA-199a-5p, microRNA-199a-3p, microRNA-199b-3p, microRNA-215, microRNA-335, microRNA-18b, microRNA-363, microRNA-645 and microRNA-141) and 38 genes were identified to be differentially expressed in drug-resistant ovarian cancer cells, with seven genes (NHSL1, EPHA3, USP51, ZSCAN4, EPHA7, SNCA and PI15) exhibited exactly the same expression trends in all three microarrays.
Molecular pathogenesis of follicular lymphoma.
Review
Nishikori et al., Kyoto, Japan. In J Clin Exp Hematop, 2013
With recent advances in the technology for DNA analysis, recurrent gene aberrations such as TNFRSF14, EPHA7, EZH2, CREBBP, EP300, MLL2 and MEF2B have been identified.
Functional genomics lead to new therapies in follicular lymphoma.
Review
Wendel et al., New York City, United States. In Ann N Y Acad Sci, 2013
We genetically dissected the common deletion of chromosome 6q and identified the ephrin receptor A7 (EPHA7) as a tumor suppressor in lymphoma.
Pathogenesis of follicular lymphoma.
Review
Gascoyne et al., Vancouver, Canada. In J Clin Invest, 2012
Most tumors are characterized by recurrent secondary genetic alterations including genomic gains, losses, and mutations, some providing a growth advantage, including alterations in MLL2, EPHA7, TNFRSF14, and EZH2.
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
Impact
Thomas et al., Köln, Germany. In Nat Genet, 2012
Furthermore, we observed mutations in PTEN, SLIT2 and EPHA7, as well as focal amplifications of the FGFR1 tyrosine kinase gene.
Transcriptional mechanisms of EphA7 gene expression in the developing cerebral cortex.
GeneRIF
Vanderhaeghen et al., Brussels, Belgium. In Cereb Cortex, 2012
Our study identifies a novel repertoire of cortical neuron genes that may act upstream of, or together with EphA7, to control the patterning of cortical areas.
Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma.
Impact
Look et al., Boston, United States. In Cancer Cell, 2011
identify EPHA7 as a tumor suppressor gene residing in the 6q-deleted region in follicular lymphoma.
The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma.
Impact
GeneRIF
Wendel et al., New York City, United States. In Cell, 2011
EPHA7 acts as a tumor suppressor in vivo and is targeted by genomic deletions and differential epigenetic silencing in human lymphomas.
Identification of EphA7 BAC clone containing a long-range dorsal midline-specific enhancer.
GeneRIF
Park et al., Seoul, South Korea. In Bmb Rep, 2011
The dorsal midline-specific EphA7 enhancer resides on the 457D20 EphA7 BAC clone and is localized to a 35 kb genomic region in between +345.7 kb to +379.8 kb downstream of the EphA7 transcription start site.
Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.
GeneRIF
Chen et al., Nashville, United States. In Plos One, 2010
Data found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets.
Exploring the link between germline and somatic genetic alterations in breast carcinogenesis.
GeneRIF
Pujana et al., Barcelona, Spain. In Plos One, 2009
Data shew that the identification of three novel candidates as EPH receptor genes might indicate a link between perturbed compartmentalization of early neoplastic lesions and breast cancer risk and progression.
Ephrin signalling controls brain size by regulating apoptosis of neural progenitors.
Impact
GeneRIF
Vanderhaeghen et al., Brussels, Belgium. In Nature, 2005
ephrin-A/EphA receptor signalling plays a key role in controlling the size of the mouse cerebral cortex by regulating cortical progenitor cell apoptosis
Regulation of repulsion versus adhesion by different splice forms of an Eph receptor.
Impact
Frisén et al., Stockholm, Sweden. In Nature, 2000
During neurulation, ephrin-A5 is co-expressed with its cognate receptor EphA7 in cells at the edges of the dorsal neural folds.
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