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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eph receptor A5

EphA5, Rak, FRK, BK2
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Eph, HAD, V1a, Src
Papers using EphA5 antibodies
EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to Rho-dependent actino/myosin contractility
Vitelli Alessandra et al., In Journal of Oncology, 2006
... Human full length cDNA clones EphA1, EphA2, and EphA5 (Origene), EphA3, and EphA7 (Invitrogen ...
Papers on EphA5
High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.
Sepulveda et al., New York City, United States. In Mod Pathol, Feb 2016
Overall, 13 genes had significantly increased CpG methylation in gastric cancer vs non-metaplastic mucosa (BRINP1, CDH11, CHFR, EPHA5, EPHA7, FGF2, FLI1, GALR1, HS3ST2, PDGFRA, SEZ6L, SGCE, and SNRPN).
Testing of candidate single nucleotide variants associated with paclitaxel neuropathy in the trial NCCTG N08C1 (Alliance).
Beutler et al., Rochester, United States. In Cancer Med, Feb 2016
Two of these, rs7349683 in the EPHA5 and rs3213619 in ABCB1 were found to be significantly associated with PIPN with an Odds ratios OR = 2.07 (P = 0.02) and OR = 0.12 (P = 0.03), respectively.
Ligand-targeted theranostic nanomedicines against cancer.
Pasqualini et al., Torino, Italy. In J Control Release, Feb 2016
These studies corroborate the notion that unique receptor proteins such as IL-11Rα, GRP78, EphA5, among others, are differentially overexpressed in tumors and present opportunities to deliver tumor-specific therapeutic drugs.
Genetic polymorphisms and paclitaxel- or docetaxel-induced toxicities: A systematic review.
Boven et al., Amsterdam, Netherlands. In Cancer Treat Rev, Dec 2015
Recent studies include variants in TUBB2A, EPHA5 and EPHA6 for a possible association with neurotoxicity.
C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex.
Song et al., Singapore, Singapore. In Plos One, Dec 2015
The identification that EphA2 and EphA5 bind to the MSP domain with higher affinity than EphA4 provides a biophysical basis for further exploring whether other than inducing ALS-like syndrome, the HCV infection might also trigger pathogenesis associated with signalling pathways mediated by EphA2 and EphA5.
Mutations leading to constitutive active gp130/JAK1/STAT3 pathway.
Zucman-Rossi et al., Paris, France. In Cytokine Growth Factor Rev, Oct 2015
(1) 60% of IHCA show IL-6 signal transducer (IL6ST; gp130) mutations; (2) 10% harbor mutations of the Fyn-related kinase FRK; (3) 5% harbor mutations in STAT3; (4) 5% harbor somatic mutations in the GNAS complex locus; and (5) 1% of IHCA harbor mutations in the Janus kinase 1 (JAK1).
Mining candidate genes associated with powdery mildew resistance in cucumber via super-BSA by specific length amplified fragment (SLAF) sequencing.
Zhou et al., Hangzhou, China. In Bmc Genomics, 2014
METHODS: A segregating population comprising 251 F2 individuals was developed using H136 (female parent) as susceptible parent and BK2 (male parent) as resistance donor.
The role of dasatinib in the management of chronic myeloid leukemia.
Chen et al., Nanjing, China. In Drug Des Devel Ther, 2014
It potently inhibits BCR/ABL and SRC-family kinases (SRC, LCK, HCK, YES, FYN, FGR, BLK, LYN, FRK), as well as c-KIT, PDGFR-a and -b, and ephrin receptor kinase.
Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.
Zucman-Rossi et al., Paris, France. In Cancer Cell, 2014
Here, exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors.
Substantial roles of hexokinase and fructokinase in the effects of sugars on plant physiology and development.
David-Schwartz et al., Israel. In J Exp Bot, 2014
This review describes the long- and short-term effects mediated by HXK and FRK in various tissues, as well as the role of these enzymes in the coordination of sugar production with the absorption of light, CO2, water, and minerals.
Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum.
Morielli et al., Burlington, United States. In J Neurosci, 2012
Cell-surface Kv1.2 alpha-subunit levels are controlled by secretin-regulated Kv1.2 endocytic trafficking.
Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation.
Gao et al., Nanjing, China. In Am J Pathol, 2012
The results demonstrate that Gsdma3 causes immune-mediated destruction of bulge stem cells plays a crucial role in the pathogenesis of alopecia in AE mice, and this strain might be implicated in other PCAs including lichen planopilaris.
MicroRNA-34a regulates migration of chondroblast and IL-1β-induced degeneration of chondrocytes by targeting EphA5.
Jin et al., Iksan, South Korea. In Biochem Biophys Res Commun, 2012
these data suggest that miR-34a is a negative modulator of chondrogenesis, particularly in migration of chondroblasts, by targeting EphA5 and resulting inhibition of cellular condensation during chondrogenesis of chick limb mesenchymal cells.
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
Seddon et al., Boston, United States. In Hum Mol Genet, 2011
Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors.
Pandiella et al., Salamanca, Spain. In Clin Cancer Res, 2011
Among the most sensitive dasatinib targets are ABL, the SRC family kinases (SRC, LCK, HCK, FYN, YES, FGR, BLK, LYN, and FRK), and the receptor tyrosine kinases c-KIT, platelet-derived growth factor receptor (PDGFR) α and β, discoidin domain receptor 1 (DDR1), c-FMS, and ephrin receptors.
Gsdma3 gene is needed for the induction of apoptosis-driven catagen during mouse hair follicle cycle.
Lian et al., Chongqing, China. In Histochem Cell Biol, 2011
Gsdma3 gene mutation interfered with catagen formation during mouse hair follicle cycle and, by upregulation of Caspase-3 expression and promotion of apoptosis, Gsdma3 gene could play an essential role in normal catagen induction.
Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Lin et al., Houston, United States. In Cancer Cell, 2009
Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms.
A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting.
Sakano et al., Tokyo, Japan. In Cell, 2007
Using the transgenic mouse in which the majority of OSNs express a particular OR, we identified such genes coding for the homophilic adhesive molecules Kirrel2/Kirrel3 and repulsive molecules ephrin-A5/EphA5.
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.
Julius et al., San Francisco, United States. In Nature, 2001
Bradykinin and nerve growth factor (NGF) are two such pro-algesic agents that activate G-protein-coupled (BK2) and tyrosine kinase (TrkA) receptors, respectively, to stimulate phospholipase C (PLC) signalling pathways in primary afferent neurons.
Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor.
Peralta et al., Cambridge, United States. In Cell, 1994
Furthermore, analysis of neuroblastoma cells revealed that a similar tyrosine kinase-dependent pathway links endogenous G protein-coupled receptors to suppression of the native RAK channel.
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