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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

EPH receptor A2

EphA2, Eck
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Eph, Ephrin-A1, CAN, HAD, V1a
Papers using EphA2 antibodies
EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to Rho-dependent actino/myosin contractility
Supplier
Vitelli Alessandra et al., In Journal of Oncology, 2006
... generate the stable Hek293 cell line expressing EphA2 in an inducible manner, 293/EphA2, the human EphA2 cDNA (NM_004431) was cloned from Origene Full Length Clone into ...
Java Treeview–extensible visualization of microarray data.
Supplier
Kelso Janet, In PLoS ONE, 2003
... purchased a recombinant murine EphA2-Fc chimera (R&D Systems, Minneapolis, MN), polyclonal antibodies derived in rabbits against EphA2 and EFNA1 (Santa Cruz Biotechnologies, Santa Cruz, CA), a horseradish peroxidase–linked anti-mouse and ant-rabbit secondary antibodies (Cell Signaling Biotechnology, Beverly, MA), and ...
The New S Language: A Programming Environment for Data Analysis and Graphics;
Supplier
Zhang Lin, In PLoS ONE, 1997
... Antibodies against the following proteins were used: rabbit anti-EphA2 (Life Technologies/Zymed Laboratories, Carlsbad, CA; clone ...
Papers on EphA2
EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer.
New
Chen et al., Nashville, United States. In Cancer Res, Feb 2016
Here we found that EPHA2 is overexpressed in EGFR TKI-resistant tumor cells.
Inter and intra-population phenotypic and genotypic structuring in the European whitefish Coregonus lavaretus, a rare freshwater fish in Scotland.
New
Praebel et al., Tromsø, Norway. In J Fish Biol, Feb 2016
UNASSIGNED: This study revealed between-lake genetic structuring between Coregonus lavaretus collected from the only two native populations of this species in Scotland, U.K. (Lochs Eck and Lomond) evidenced by the existence of private alleles (12 in Lomond and four in Eck) and significant genetic differentiation (FST  = 0·056) across 10 microsatellite markers.
Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions.
New
Sansom et al., Oxford, United Kingdom. In Structure, Jan 2016
In simulations of the complete EphA2 ectodomain plus the transmembrane region, we show that FN2 anchors the otherwise flexible ectodomain at the surface of the bilayer.
C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex.
New
Song et al., Singapore, Singapore. In Plos One, Dec 2015
The identification that EphA2 and EphA5 bind to the MSP domain with higher affinity than EphA4 provides a biophysical basis for further exploring whether other than inducing ALS-like syndrome, the HCV infection might also trigger pathogenesis associated with signalling pathways mediated by EphA2 and EphA5.
Malaria parasites target the hepatocyte receptor EphA2 for successful host infection.
New
Impact
Kappe et al., Seattle, United States. In Science, Dec 2015
We found that the hepatocyte EphA2 receptor was critical for establishing a permissive intracellular replication compartment, the parasitophorous vacuole.
Host cell kinases and the hepatitis C virus life cycle.
Review
New
Baumert et al., Strasbourg, France. In Biochim Biophys Acta, Oct 2015
During viral entry, cellular kinases, including EGFR, EphA2 and PKA, regulate the localization of host HCV entry factors and induce receptor complex assembly.
Preclinical and clinical development of siRNA-based therapeutics.
Review
New
Lopez-Berestein et al., Houston, United States. In Adv Drug Deliv Rev, Jul 2015
Here, we review the development of siRNAs as therapeutic agents from early design to clinical trial, with special emphasis on the development of EphA2-targeting siRNAs for ovarian cancer treatment.
Expression of EphA2 protein is positively associated with age, tumor size and Fuhrman nuclear grade in clear cell renal cell carcinomas.
Wang et al., Nanjing, China. In Int J Clin Exp Pathol, 2014
The receptor tyrosine kinase of EphA2 has been shown frequently overexpressed in various types of human carcinomas, which implicated that it plays important roles in carcinogenesis.
A Comprehensive Outline of Trastuzumab Resistance Biomarkers in HER2 Overexpressing Breast Cancer.
Review
Győrffy et al., Budapest, Hungary. In Curr Cancer Drug Targets, 2014
These include HER2 amplification, impaired access to the binding site (p95HER2, Δ16HER-2, MUC4), augmented signaling through other ERBB family receptors (HER1, HER3, HER4) and their ligands, activation of HER2 targets by alternate heterodimers (EphA2, IGF-1R, GDF15, MUC1*), signaling triggered by downstream members (PIK3CA, PTEN, SRC, mTOR), altered expression of cell cycle and apoptotic regulators (CDKs, p27(kip1), Bcl-2), hormone receptor status, resistance to antibody-dependent cellular cytotoxicity (FcγR), and altered miRNA expression signatures.
Spatial control of membrane receptor function using ligand nanocalipers.
Impact
Teixeira et al., Stockholm, Sweden. In Nat Methods, 2014
Using these 'nanocalipers' to present ephrin ligands, we showed that the nanoscale spacing of ephrin-A5 directs the levels of EphA2 receptor activation in human breast cancer cells.
Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas.
Impact
Okada et al., Pittsburgh, United States. In J Clin Oncol, 2014
PATIENTS AND METHODS: GAAs were EphA2, interleukin-13 receptor alpha 2 (IL-13Rα2), and survivin, and their peptide epitopes were emulsified in Montanide-ISA-51 and given every 3 weeks with intramuscular polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose for eight courses, followed by booster vaccinations every 6 weeks.
Clinical impact of hepatitis B and C virus envelope glycoproteins.
Review
Schvoerer et al., Vandœuvre-lès-Nancy, France. In World J Gastroenterol, 2013
HCV entry is a complex multistep process involving multiple cell cofactors (glycosaminoglycans, low density lipoprotein receptor, SR-B1, CD81, claudin-1, occludin, EGFR, EphA2) in the interaction with HCV E1/E2 envelope glycoproteins.
The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas.
Impact
Vescovi et al., Milano, Italy. In Cancer Cell, 2013
We found that the EphA2 receptor tyrosine kinase is overexpressed in hGBM TPCs.
The homeobox only protein homeobox (HOPX) and colorectal cancer.
Review
Watanabe et al., Sagamihara, Japan. In Int J Mol Sci, 2012
HOPX downstream targets were identified in CRC cell lines and hold promise as candidates for therapeutic targets of CRC, such as EphA2 or AP-1.
Tumour virology. Entry requirements.
Impact
Seton-Rogers, In Nat Rev Cancer, 2012
Two papers show that EPHA2 is a receptor for Kaposi's sarcoma-associated herpesvirus (KSHV) and is required for KSHV infection of endothelial cells.
The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus.
Impact
GeneRIF
Neipel et al., Erlangen, Germany. In Nat Med, 2012
results identify EphA2, a tyrosine kinase with known functions in neovascularization and oncogenesis, as an entry receptor for Kaposi's sarcoma-associated herpesvirus
Kaposi's sarcoma-associated herpesvirus interacts with EphrinA2 receptor to amplify signaling essential for productive infection.
GeneRIF
Chandran et al., North Chicago, United States. In Proc Natl Acad Sci U S A, 2012
Data show that EphA2 receptor acts as a regulator of Kaposi's sarcoma-associated herpesvirus (KSHV)-induced signal molecules and KSHV entry in endothelial cells and suggest that the EphA2 receptor is an attractive target for controlling KSHV infection.
Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor.
GeneRIF
Debinski et al., Winston-Salem, United States. In J Biol Chem, 2012
analysis of structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor
Solution structure of the first Sam domain of Odin and binding studies with the EphA2 receptor.
GeneRIF
Leone et al., Napoli, Italy. In Biochemistry, 2012
Sam (sterile alpha motif) domains of Odin, a member of the ANKS (ankyrin repeat and sterile alpha motif domain-containing) family of proteins, are important for the regulation of EphA2 endocytosis.
EPHA2 polymorphisms and age-related cataract in India.
GeneRIF
Fletcher et al., Madurai, India. In Plos One, 2011
Our results in the Indian population agree with previous studies of the association of EPHA2 variants with cortical cataracts.
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