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EPH receptor A10

EphA10
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Eph, EphB3, Eco, EphA2, ALK
Papers on EphA10
Antitumor effect of metformin on cholangiocarcinoma: In vitro and in vivo studies.
New
Masaki et al., Japan. In Oncol Rep, Dec 2015
In addition, it reduced the phosphorylation of Axl, EphA10, ALK and PYK, as well as tumor proliferation in athymic nude mice with xenograft tumors.
Generation and characterization of a bispecific diabody targeting both EPH receptor A10 and CD3.
New
Tsunoda et al., Ibaraki, Japan. In Biochem Biophys Res Commun, Feb 2015
The EPH receptor A10 (EphA10) is up-regulated in breast cancer but is not normally expressed in healthy tissue, thus it has been suggested that EphA10 may be a useful target for cancer therapy.
Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.
Castellone et al., Napoli, Italy. In Plos One, 2014
Based on our data, the robust over-expression of SOD3 increased the level of phosphorylation of the EGFR, ERBB2, RYK, ALK, FLT3, and EPHA10 receptor tyrosine kinases with the consequent downstream activation of the SRC, FYN, YES, HCK, and LYN kinases.
Ligand stimulation induces clathrin- and Rab5-dependent downregulation of the kinase-dead EphB6 receptor preceded by the disruption of EphB6-Hsp90 interaction.
Freywald et al., Saskatoon, Canada. In Cell Signal, 2014
Each bears one kinase-inactive member, EphA10 and EphB6, respectively, suggesting an important role for these molecules in the Eph signalling network.
A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy.
Tsunoda et al., Ibaraki, Japan. In Plos One, 2014
Ephrin receptor A10 (EphA10), a transmembrane receptor that binds to ephrin, is a newly identified breast cancer marker protein that has also been detected in HER2-negative tissue.
Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers.
Tsunoda et al., Ibaraki, Japan. In J Control Release, 2014
Ephrin receptor A10 (EphA10) is a relatively uncharacterized protein which is expressed in many breast cancers but not expressed in normal breast tissues.
Eph receptor A10 has a potential as a target for a prostate cancer therapy.
Tsunoda et al., Ibaraki, Japan. In Biochem Biophys Res Commun, 2014
We recently identified Eph receptor A10 (EphA10) as a novel breast cancer-specific protein.
PreImplantation factor (PIF*) promotes embryotrophic and neuroprotective decidual genes: effect negated by epidermal growth factor.
Barnea et al., New Haven, United States. In J Neurodev Disord, 2013
RESULTS: In HESC, PIF promotes neural differentiation and transmission genes (TLX2, EPHA10) while inhibiting retinoic acid receptor gene, which arrests growth.
Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients.
Tsunoda et al., Ibaraki, Japan. In Cancer Med, 2013
Eph receptor A10 (EphA10) is a valuable breast cancer marker that is highly expressed in breast cancer tissues by comparison with normal breast tissues, as we previously reported.
Increased EphA/ephrinA expression in hippocampus of pilocarpine treated mouse.
Yao et al., Chengdu, China. In Epilepsy Res, 2013
EphA10 and ephrinA4 were increased significantly following epileptogenesis, and mossy fiber sprouting appeared after SE.
A paradigm shift in EPH receptor interaction: biological relevance of EPHB6 interaction with EPHA2 and EPHB2 in breast carcinoma cell lines.
GeneRIF
Kandpal et al., Pomona, United States. In Cancer Genomics Proteomics, 2011
EPHA10 does not interact with EPHB6 in breast neoplasms
Dancing with the dead: Eph receptors and their kinase-null partners.
Review
Freywald et al., Regina, Canada. In Biochem Cell Biol, 2011
Interestingly, however, Eph receptors also actively utilize three kinase-deficient receptor tyrosine kinases, EphB6, EphA10, and Ryk, in their signaling network.
Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells.
GeneRIF
Zapata et al., Madrid, Spain. In Leuk Res, 2009
CLL B-cells showed a more heterogeneous Eph/EFN profile, specially EFNA4, EphB6 and EphA10.
Comparative integromics on Eph family.
Katoh et al., Japan. In Int J Oncol, 2006
EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4 and EPHB6 are EPH family receptors for Ephrin family ligands.
Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis.
Review
Finne et al., Oslo, Norway. In Biochim Biophys Acta, 2005
Here we present a not yet described member of this family denoted EphA10.
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