Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.
London, United Kingdom. In Curr Opin Neurobiol, Nov 2015
The findings strongly implicate genes related to the immune response (CR1, CD33, MS4A, CLU, ABCA7, EPHA1 and HLA-DRB5-HLA-DRB1), endocytosis (BIN1, PICALM, CD2AP, EPHA1 and SORL1) and lipid biology (CLU, ABCA7 and SORL1) [2-8], and many encode proteins which are highly expressed in microglia .
The Role of Ephs and Ephrins in Memory Formation.
Haifa, Israel. In Int J Neuropsychopharmacol, Oct 2015
The Eph receptors and their cognate ephrin ligands have been shown to be involved in these key neuronal processes by regulating events such as presynaptic transmitter release, postsynaptic glutamate receptor conductance and trafficking, synaptic glutamate reuptake, and dendritic spine morphogenesis.
Eph receptors and ephrins: therapeutic opportunities.
Los Angeles, United States. In Annu Rev Pharmacol Toxicol, 2014
The erythropoietin-producing hepatocellular carcinoma (Eph) receptor tyrosine kinase family plays important roles in developmental processes, adult tissue homeostasis, and various diseases.
Growth factor receptors define cancer hierarchies.
Cleveland, United States. In Cancer Cell, 2013
Two papers in Cancer Cell, one in this issue (Day and colleagues) and one in a recent issue (Binda and colleagues), describe how Eph receptor tyrosine kinases critically define and regulate the growth of cancer stem cells.