Amman, Jordan. In J Thromb Haemost, Jan 2016
The underlying molecular mechanism is thought to be due to warfarin-induced thrombin depletion, however newer studies hint at an alternate mechanism involving reduction in activate protein C and endothelial protein C receptor signaling.
Cytoprotective-selective activated protein C therapy for ischaemic stroke.
Los Angeles, United States. In Thromb Haemost, 2014
In addition to its natural anticoagulant functions, APC conveys multiple direct cytoprotective effects on many different cell types that involve multiple receptors including protease activated receptor (PAR) 1, PAR3, and the endothelial protein C receptor (EPCR).