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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein C receptor, endothelial

EPCR, endothelial protein C receptor, endothelial cell protein C receptor
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APC, thrombomodulin, CAN, V1a, HAD
Papers on EPCR
Suppressive effects of polyozellin on endothelial protein C receptor shedding via inhibiting TACE activity and MAP kinases.
Bae et al., Taegu, South Korea. In Fitoterapia, Jan 2016
Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway.
Anticoagulation-Related Nephropathy.
Rangaswami et al., Amman, Jordan. In J Thromb Haemost, Jan 2016
The underlying molecular mechanism is thought to be due to warfarin-induced thrombin depletion, however newer studies hint at an alternate mechanism involving reduction in activate protein C and endothelial protein C receptor signaling.
Activation of Protein C and Thrombin Activable Fibrinolysis Inhibitor on Cultured Human Endothelial Cells.
Weitz et al., Hamilton, Canada. In J Thromb Haemost, Jan 2016
By binding PC and presenting it to the thrombin-TM complex, endothelial cell protein C receptor (EPCR) enhances PC activation.
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
Lapidot et al., Israel. In Nat Med, Nov 2015
We report that signaling cascades that are traditionally viewed as coagulation related also control retention of endothelial protein C receptor-positive (EPCR(+)) LT-HSCs in the bone marrow and their recruitment to the blood via two pathways mediated by protease activated receptor 1 (PAR1).
Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania.
Lavstsen et al., Copenhagen, Denmark. In Malar J, 2014
BACKGROUND: Endothelial protein C receptor (EPCR) was recently identified as a key receptor for Plasmodium falciparum erythrocyte membrane protein 1 mediating sequestration of P. falciparum-infected erythrocytes in patients suffering from severe malaria.
Direct and Indirect Effects of Cytomegalovirus-Induced γδ T Cells after Kidney Transplantation.
Déchanet-Merville et al., Bordeaux, France. In Front Immunol, 2014
A multiple of Vδ2(neg) γδ TCR ligands are apparently recognized on CMV-infected cells, the first one identified being the major histocompatibility complex-related molecule endothelial protein C receptor.
Changes of expression of the protein C pathway components in LPS-induced endotoxemia--implication for sepsis.
Suzuki et al., Suzuka, Japan. In Cardiovasc Hematol Disord Drug Targets, 2014
The protein C (PC) anticoagulant pathway, one of the important pathways related to physiological thrombosis formation, includes PC, thrombomodulin (TM), endothelial PC receptor (EPCR), protein S (PS) and C4b-binding protein (C4BP).
Differential Plasmodium falciparum surface antigen expression among children with Malarial Retinopathy.
Bull et al., Kilifi, Kenya. In Sci Rep, 2014
PfEMP1 sub-groups called "DC8" and "DC13" have been proposed to cause brain pathology through interactions with endothelial protein C receptor.
Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding.
Gamain et al., Paris, France. In Malar J, 2014
A restricted sub-set of var genes encoding for PfEMP1s possessing the domain cassettes DC8 and DC13 were found to bind to the endothelial protein C receptor (EPCR).
Cytoprotective-selective activated protein C therapy for ischaemic stroke.
Griffin et al., Los Angeles, United States. In Thromb Haemost, 2014
In addition to its natural anticoagulant functions, APC conveys multiple direct cytoprotective effects on many different cell types that involve multiple receptors including protease activated receptor (PAR) 1, PAR3, and the endothelial protein C receptor (EPCR).
CD36 and malaria: friends or foes? A decade of data provides some answers.
Kain et al., Toronto, Canada. In Trends Parasitol, 2014
CD36 polymorphisms lack association with severity, and isolates that cause severe disease primarily bind to endothelial protein C receptor (EPCR) rather than to CD36.
Severe malaria is associated with parasite binding to endothelial protein C receptor.
Theander et al., Copenhagen, Denmark. In Nature, 2013
Here we identify endothelial protein C receptor (EPCR), which mediates the cytoprotective effects of activated protein C, as the endothelial receptor for DC8 and DC13 PfEMP1.
Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor.
Déchanet-Merville et al., Birmingham, United Kingdom. In Nat Immunol, 2012
Our results demonstrate how a gammadelta TCR mediates recognition of broadly stressed human cells by engaging endothelial protein C receptor
Endothelial protein C receptor expressed by ovarian cancer cells as a possible biomarker of cancer onset.
Mirshahi et al., Paris, France. In Int J Oncol, 2012
in cancer patients, the levels of sEPCR are significantly higher than the normal range compared to healthy volunteers
Factor VIIa binding to endothelial cell protein C receptor: differences between mouse and human systems.
Rao et al., Tyler, United States. In Thromb Haemost, 2012
Murine FVIIa binds poorly to murine EPCR.
Influence of endothelial cell protein C receptor on plasma clearance of factor VIIa.
Rao et al., In J Thromb Haemost, 2012
Letter: Endothelial cell protein C receptor does not appear to play a significant role in human factor VIIa clearance from plasma.
The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.
Gagnon et al., Toronto, Canada. In Blood, 2012
Studies indicate a significant association between the PROCR rs867186 variant and venous thromboembolism (VTE).
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.
Nawroth et al., Heidelberg, Germany. In Nat Med, 2007
APC modulates the mitochondrial apoptosis pathway via the protease-activated receptor PAR-1 and the endothelial protein C receptor EPCR in glucose-stressed cells.
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective.
Zlokovic et al., Rochester, United States. In Nat Med, 2003
Cytoprotection of brain endothelium by APC in vitro required endothelial protein C receptor (EPCR) and protease-activated receptor-1 (PAR-1), as did its in vivo neuroprotective activity in a stroke model of mice with a severe deficiency of EPCR.
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