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Enhancer of polycomb homolog 1

EPC1, EpLI, Epl1, Enhancer of Polycomb 1
A member of the Glycosyltransferase Family 64, homologous to Poplar cambium-expressed GT64 gene. The EPC1 protein plays a critical role during plant development in maintaining the integrity of organs via cell-cell adhesion, thereby providing mechanical strength and facilitating the movement of metabolites throughout the plant. (from NCBI)
Top mentioned proteins: Polycomb, Histone, ACID, PHF-1, JAZF1
Papers on EPC1
Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures.
New
Engelmann et al., Rostock, Germany. In Nucleic Acids Res, Feb 2016
Here we report a novel function for EPC1 (enhancer of polycomb homolog 1) in DNA damage protection.
Bile Salts at Low pH Cause Dilation of Intercellular Spaces in In Vitro Stratified Primary Esophageal Cells, Possibly by Modulating Wnt Signaling.
New
Peters et al., Rochester, United States. In J Gastrointest Surg, Jan 2016
DISCUSSION: Human telomerase reverse transcriptase (hTERT) immortalized primary esophageal EPC1 cells were grown on polyester transwell surfaces in calcium-enriched media.
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.
Review
New
Thway et al., London, United Kingdom. In Ann Diagn Pathol, Jan 2016
It is now established that OFMTs represent translocation-associated tumors, with up to 85% associated with recurrent gene rearrangements, mostly involving the PHF1 gene (including in typical, atypical, and malignant neoplasms), with EP400-PHF1 in approximately 40% of tumors, and ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions also described.
Genomic structural variants are linked with intellectual disability.
New
Thompson et al., Moscow, Russia. In J Neural Transm, Sep 2015
containing the genes ZEB1, c10orf68 and EPC1.
Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett's Esophagus: Regulation via Dickkopf-1.
New
Shaker et al., Milwaukee, United States. In Neoplasia, Jul 2015
METHODS: Esophageal tissues from healthy and BE patients without dysplasia were analyzed for Wnt target gene expression by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry. Esophageal squamous (EPC1-& EPC2-hTERT), BE metaplastic (CP-A), and adenocarcinoma (OE33) cell lines were characterized for Wnt activation by qRT-PCR, Western blot, and luciferase assay.
The fungal cerato-platanin protein EPL1 forms highly ordered layers at hydrophobic/hydrophilic interfaces.
New
Seidl-Seiboth et al., Vienna, Austria. In Soft Matter, Apr 2015
In this study, by means of atomic force microscopy (AFM), EPL1, a member of the CPP family was shown to form highly ordered monolayers at a hydrophobic surface/liquid-interface.
Evaluation of Dot Immunogold Filtration Assay (DIGFA) By Recombinant Protein EPC1 for Anti- Echinococcus granulosus IgG Antibody.
Etebar et al., Tehrān, Iran. In Iran J Parasitol, 2015
Colloidal gold was prepared by controlled reduction of a boiling solution of chloroauric acid (H [AuCl4]) with sodium citrate and labeled with recombinant EPC1.
p120-catenin down-regulation and epidermal growth factor receptor overexpression results in a transformed epithelium that mimics esophageal squamous cell carcinoma.
Stairs et al., United States. In Am J Pathol, 2015
Specifically, p120ctn down-regulation coupled with EGFR overexpression in human esophageal keratinocytes (EPC1-PE) was required to promote invasion.
RNA interference targeting enhancer of polycomb1 exerts anti-tumor effects in lung cancer.
Zhang et al., Harbin, China. In Int J Clin Exp Pathol, 2014
A new therapy target, enhancer of polycomb1 (EPC1) knocked down by short hairpin RNA (shRNA) interference technology, for lung cancer was established to investigate its effects on lung cancer in present study.
Sm2, a paralog of the Trichoderma cerato-platanin elicitor Sm1, is also highly important for plant protection conferred by the fungal-root interaction of Trichoderma with maize.
Seidl-Seiboth et al., Vienna, Austria. In Bmc Microbiol, 2014
It was previously shown that the cerato-platanin protein Sm1 from T. virens - and to a lesser extent its homologue Epl1 from Trichoderma atroviride - induce plant defense responses.
The Epl1 and Sm1 proteins from Trichoderma atroviride and Trichoderma virens differentially modulate systemic disease resistance against different life style pathogens in Solanum lycopersicum.
Casas-Flores et al., San Luis Potosí, Mexico. In Front Plant Sci, 2014
T. virens and T. atroviride secrete the proteins Sm1 and Epl1, respectively, which elicit local and systemic disease resistance in plants.
High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis.
FANTOM consortium et al., Stockholm, Sweden. In Blood, 2014
Our epigenetic transcriptome analysis revealed cell type- (eg, HELLS and ACTL6A), lineage- (eg, MLL), and/or leukemia- (eg, CHD2, CBX8, and EPC1) specific expression of several epigenetic factors.
Functional and cancer genomics of ASXL family members.
Review
Katoh, Tokyo, Japan. In Br J Cancer, 2013
EPC1-ASXL2 gene fusion occurs in adult T-cell leukaemia/lymphoma.
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.
Impact
Grimmond et al., Sydney, Australia. In Nature, 2012
We define 16 significantly mutated genes, reaffirming known mutations (KRAS, TP53, CDKN2A, SMAD4, MLL3, TGFBR2, ARID1A and SF3B1), and uncover novel mutated genes including additional genes involved in chromatin modification (EPC1 and ARID2), DNA damage repair (ATM) and other mechanisms (ZIM2, MAP2K4, NALCN, SLC16A4 and MAGEA6).
Enhancer of polycomb1 lessens neointima formation by potentiation of myocardin-induced smooth muscle differentiation.
GeneRIF
Kee et al., South Korea. In Atherosclerosis, 2012
results indicate that Epc1 induces vascular smooth muscle differentiation by interacting with myocardin to induce serum response factor-dependent smooth muscle genes; propose that Epc1 acts as a novel negative regulator of neointima formation after carotid injury
Ret finger protein inhibits muscle differentiation by modulating serum response factor and enhancer of polycomb1.
GeneRIF
Kook et al., Kwangju, South Korea. In Cell Death Differ, 2012
Epc1-induced enhancements of SRF-dependent multinucleation, transactivation of the skeletal alpha-actin promoter, binding of SRF to the serum response element, and muscle-specific gene induction were blocked by RFP.
Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma.
GeneRIF
Morishita et al., Miyazaki, Japan. In Genes Chromosomes Cancer, 2009
SNP array CGH analysis of the breakpoint region in 3 ATLL-related cell lines and 4 patient samples revealed the chromosomal breakpoints are localized within the EPC1 gene locus in an ATLL-derived cell line (SO4) and in one patient with acute-type ATLL.
Enhancer of polycomb1 acts on serum response factor to regulate skeletal muscle differentiation.
GeneRIF
Kook et al., Kwangju, South Korea. In J Biol Chem, 2009
Epc1 is required for skeletal muscle differentiation by recruiting both SRF and p300 to the SRE of muscle-specific gene promoters
The ectopically parting cells 1-2 (epc1-2) mutant exhibits an exaggerated response to abscisic acid.
GeneRIF
Jackson et al., Warwick, United Kingdom. In J Exp Bot, 2006
EPC1 does not affect cell adhesion but has a role in processes affecting plant growth and development.
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