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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Prostaglandin E receptor 2

EP2, EP2 receptor, He2
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: EP4, EP1, V1a, cyclooxygenase, EP3
Papers using EP2 antibodies
EP2 receptor mediated cAMP release is augmented by PGF2α activation of the FP receptor via the calcium-calmodulin pathway
Supplier
Jabbour H.N. et al., In Cellular Signalling, 2006
... The EP2 and FP receptor primary antibodies were purchased from Cayman Chemical Company (Axxora, Nottingham, ...
Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer
Supplier
Jiang Shun-Yuan et al., In Journal of Biomedical Science, 2001
... of TOPFLASH or CREB reporter plasmid along with 100 ng of indicated control vector or EP2 TrucClone™ cDNA (PTGER2, OriGene Technologies, Inc ...
Papers on EP2
Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling.
New
Picado et al., Barcelona, Spain. In Rhinology, Feb 2016
RESULTS: NM-C and NP-AERD samples and fibroblasts expressed EP2, EP3 and EP4 at baseline.
Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice.
New
Wang et al., Baltimore, United States. In J Cereb Blood Flow Metab, Feb 2016
Using genetic and pharmacologic approaches, we investigated the role of EP2 receptor in two mouse models of ICH induced by intrastriatal injection of collagenase or autologous arterial whole blood.
A facile and dynamic assay for the detection of peptide aggregation.
New
He et al., Guangzhou, China. In Anal Bioanal Chem, Feb 2016
In this study, by choosing a tryptophan-containing peptide of EP2, we investigated its fluorescence spectroscopic characteristics in the process of PAs.
Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.
Review
New
Wang et al., Guangzhou, China. In Prostaglandins Other Lipid Mediat, Jan 2016
There is clear evidence that activation of EP2 and EP4 receptors exerts cerebroprotection against ischemic stroke.
On the evolution of the pulmonary alveolar lipofibroblast.
Review
New
Rehan et al., Torrance, United States. In Exp Cell Res, Jan 2016
Namely, Parathyroid Hormone-related Protein (PTHrP) signaling, expression of Adipocyte Differentiation Related Protein, leptin, peroxisome proliferator activator receptor gamma, and the prostaglandin E2 receptor EP2- which are all stretch-regulated, explaining how and why surfactant production is 'on-demand' in service to ventilation-perfusion matching.
Discovery of highly potent dual EP2 and EP3 agonists with subtype selectivity.
New
Ohmoto et al., Ōsaka, Japan. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: The cyclic carbamate derivatives, 2-{[2-((4S)-4-{(1E,3R)-8-fluoro-3-hydroxy-4,4-dimethyl-1-octenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid (5) and 2-{[2-((4S)-4-{(1E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid (7) were identified as the first potent dual EP2 and EP3 agonists with selectivity against the EP1 and EP4 subtypes.
Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?
Review
New
Houston et al., Cork, Ireland. In Br J Pharmacol, Nov 2015
The biological effects of PGE2 are mediated by signalling through four distinct E-type prostanoid (EP) receptors - EP1 , EP2 , EP3 and EP4 .
The receptor EP3 to PGE2: A rational target to prevent atherothrombosis without inducing bleeding.
Review
New
Fabre et al., Paris, France. In Prostaglandins Other Lipid Mediat, Sep 2015
Through the activation of its receptor EP3, PGE2 sensitizes platelets to their agonists but also inhibits them through its two other receptors, EP2 and EP4.
Natural products with therapeutic potential in melanoma metastasis.
Review
New
Prieto et al., London, United Kingdom. In Nat Prod Rep, Aug 2015
As a result, over 30 natural active principles are described acting mainly through their antagonistic effects upon the TNF-α and EP2 receptors or the suppression of several protein kinases involved in metastatic pathways such as RAS, PI3K, ERK and FAK.
Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection.
New
Impact
Kaech et al., New Haven, United States. In Nat Med, Apr 2015
We found that the prostaglandin E2 (PGE₂) receptors EP2 and EP4 were upregulated on virus-specific CTLs during chronic lymphocytic choriomeningitis virus (LCMV) infection and suppressed CTL survival and function.
CCR7 Receptor Expression in Mono-MAC-1 Cells: Modulation by Liver X Receptor α Activation and Prostaglandin E 2.
Dumais et al., Sherbrooke, Canada. In Int J Inflam, 2014
In addition, our results demonstrate that engagement of the E-prostanoids 2 and 4 (EP2/EP4) receptors present on MM-1 cells is responsible for the observed increase in CCR7 mRNA expression and function during LXRα activation.
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.
Impact
Gilroy et al., Barcelona, Spain. In Nat Med, 2014
Plasma from these and patients with end-stage liver disease (ESLD) suppressed macrophage proinflammatory cytokine secretion and bacterial killing in vitro in a PGE2-dependent manner via the prostanoid type E receptor-2 (EP2), effects not seen with plasma from patients with stable cirrhosis (Child-Pugh score grade A).
Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.
Impact
Divangahi et al., Montréal, Canada. In Immunity, 2014
Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype.
The prostanoid EP4 receptor and its signaling pathway.
Review
Impact
Ishikawa et al., Yokohama, Japan. In Pharmacol Rev, 2013
It was originally identified, similar to the EP2 receptor as a G(s)α-coupled, adenylyl cyclase-stimulating receptor.
Prostanoid receptor 2 signaling protects T helper 2 cells from BALB/c mice against activation-induced cell death.
GeneRIF
Das et al., New Delhi, India. In J Biol Chem, 2012
Prostanoid receptor 2 signaling protects T helper 2 cells from BALB/c mice against activation-induced cell death.
PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice.
GeneRIF
Nüsing et al., Frankfurt am Main, Germany. In Diabetes, 2012
The data uncovered a previously unrecognized protective role of PTGS-2-derived PGE(2) in streptozotocin-induced diabetes mediated by PTGER2 and PTGER4.
A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma.
GeneRIF
Zheng et al., Nashville, United States. In Cancer Prev Res (phila), 2012
Single nucleotide polymorphism in PTGER2 associated with multiple adenomas.
Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice.
GeneRIF
Narumiya et al., Kyoto, Japan. In J Neurosci, 2012
The results of this study suggested that the PGE(2)-EP1 signaling is critical for susceptibility to repeated social defeat stress in mice through attenuation of mesocortical dopaminergic pathway.
PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth.
GeneRIF
Koller et al., Chapel Hill, United States. In Prostaglandins Other Lipid Mediat, 2012
Together this supports a mechanism by which maturation and increased contractility of the vessel is coupled to the potent smooth muscle dilatory actions of PGE(2).
Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production.
Impact
Mezey et al., Bethesda, United States. In Nat Med, 2009
Our results suggest that BMSCs (activated by LPS or TNF-alpha) reprogram macrophages by releasing prostaglandin E(2) that acts on the macrophages through the prostaglandin EP2 and EP4 receptors.
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