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Prostaglandin E receptor 1

EP1
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: EP4, EP2, EP3, cyclooxygenase, V1a
Papers using EP1 antibodies
Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor
Supplier
Rubio Ignacio et al., In BMC Cancer, 2002
... EP1, 3 and 4 receptor selective antagonists were kindly provided by Merck Frost, Canada [ ...
Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration
Supplier
Heinemann Akos et al., In Cellular and Molecular Life Sciences, 1991
... receptor agonist butaprost, the EP1/EP3 receptor agonist sulprostone, the EP4 receptor antagonist GW627368X and the EP1/I-type prostanoid (IP) receptor agonist iloprost were from Cayman Chemicals (Ann Arbor, MI, ...
Papers on EP1
Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling.
New
Picado et al., Barcelona, Spain. In Rhinology, Feb 2016
Expression of EP1-4 was assessed at baseline.
Validation of EP1 Antibody Clone for Estrogen Receptor Immunohistochemistry for Breast Cancer.
New
Hogue et al., Québec, Canada. In Anticancer Res, Jan 2016
BACKGROUND: SP1 Rabbit monoclonal antibody to estrogen receptor (ER) has long been the standard for determination of ER status in breast cancer but has been replaced by the rabbit EP1 clone.
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.
New
Engblom et al., In J Clin Invest, Jan 2016
Further, we showed that inflammation-induced PGE2 targeted EP1 receptors on striatal dopamine D1 receptor-expressing neurons and that this signaling sequence induced aversion through GABA-mediated inhibition of dopaminergic cells.
MDMA Increases Excitability in the Dentate Gyrus: Role of 5HT2A Receptor Induced PGE2 Signaling.
New
Yamamoto et al., Cincinnati, United States. In J Neurochem, Jan 2016
MDMA-induced increases in extracellular glutamate were inhibited by local administration of SC-51089, an inhibitor of the EP1 prostaglandin receptor.
Discovery of highly potent dual EP2 and EP3 agonists with subtype selectivity.
New
Ohmoto et al., Ōsaka, Japan. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: The cyclic carbamate derivatives, 2-{[2-((4S)-4-{(1E,3R)-8-fluoro-3-hydroxy-4,4-dimethyl-1-octenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid (5) and 2-{[2-((4S)-4-{(1E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid (7) were identified as the first potent dual EP2 and EP3 agonists with selectivity against the EP1 and EP4 subtypes.
Draft genome sequence of Thermococcus sp. EP1, a novel hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent on the East Pacific Rise.
New
Chen et al., Xiamen, China. In Mar Genomics, Jan 2016
strain EP1 is a novel anaerobic hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent on the East Pacific Rise.
Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?
Review
New
Houston et al., Cork, Ireland. In Br J Pharmacol, Nov 2015
The biological effects of PGE2 are mediated by signalling through four distinct E-type prostanoid (EP) receptors - EP1 , EP2 , EP3 and EP4 .
The mechanistic basis of prostacyclin and its stable analogues in pulmonary arterial hypertension: Role of membrane versus nuclear receptors.
Review
New
Gurung et al., London, United Kingdom. In Prostaglandins Other Lipid Mediat, Jul 2015
This review discusses evidence that the pharmacology of each prostacyclin (IP) receptor agonist so far developed is distinct, with non-IP receptor targets clearly contributing to the therapeutic and side effect profile of PGI2 (EP3), iloprost (EP1), treprostinil (EP2, DP1) along with a family of nuclear receptors known as peroxisome proliferator-activated receptors (PPARs), to which PGI2 and some analogues directly bind.
The Prostaglandin Transporter: Eicosanoid Reuptake, Control of Signaling, and Development of High-Affinity Inhibitors as Drug Candidates.
Review
Lu et al., United States. In Trans Am Clin Climatol Assoc, 2014
PGT knockout mice have elevated prostaglandin E2 (PGE2) and neonatal patent ductus arteriosus, which reflects PGT's control over PGE2 signaling at EP1/EP4 cell-surface receptors.
Regulatory mechanism of the gastric hyperemic response following barrier disruption: roles of cyclooxygenase-1, the prostaglandin E2/EP1 receptor and sensory neurons.
Review
Nakashima et al., Kyoto, Japan. In Curr Pharm Des, 2014
The GMBF responses induced by TC were similarly observed in the stomachs of wild-type mice and EP3 receptor knockout mice, but not in mice lacking the EP1 receptor or pretreated with an EP1 antagonist.
Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation.
GeneRIF
Barki-Harrington et al., Haifa, Israel. In J Biol Chem, 2012
new role for the EP(1) receptor in resolving inflammation through down-regulation of COX-2.
Prostanoid EP1 receptor as the target of (-)-epigallocatechin-3-gallate in suppressing hepatocellular carcinoma cells in vitro.
GeneRIF
Wu et al., Hefei, China. In Acta Pharmacol Sin, 2012
Suggest that the anti-carcinogenic effects of EGCG in hepatocellular carcinoma might be mediated, at least partially, through the suppressing EP(1) receptor expression and PGE(2) production.
Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells.
GeneRIF
Pelus et al., Indianapolis, United States. In Blood, 2012
A novel dendritic cell(DC) progenitor regulatory pathway in which PGE(2) signaling through EP1/EP3 receptors regulates Flt3 expression and downstream STAT3 activation and survivin expression, required for optimal progenitor survival and differentiation.
The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility.
GeneRIF
Bennett et al., London, United Kingdom. In J Clin Endocrinol Metab, 2012
The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility.
Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.
GeneRIF
Sveinbjörnsson et al., Stockholm, Sweden. In Plos One, 2011
Neuroblastoma express all four forms of PGE(2) receptors.
Membrane prostaglandin E synthase-1: a novel therapeutic target.
Review
Impact
Jakobsson et al., Stockholm, Sweden. In Pharmacol Rev, 2007
It has a large number of biological actions that it exerts via four types of receptors, EP1-4.
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity.
Impact
GeneRIF
Iadecola et al., New York City, United States. In Nat Med, 2006
EP1 receptors contribute to neurotoxicity by augmenting the Ca(2+) dysregulation underlying excitotoxic neuronal death
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice.
Impact
Taketo et al., Tokyo, Japan. In Nat Med, 2001
Homozygous gene knockout for other PGE(2) receptors, EP1 or EP3, did not affect intestinal polyp formation in Apc(Delta 716) mice.
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.
Impact
Narumiya et al., Kyoto, Japan. In Nature, 1998
PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors.
Cytoprotective Role of Prostaglandin D2 DP1 Receptor against Neuronal Injury Following Acute Excitotoxicity and Cerebral Ischemia
Review
Shafique Ahmad et al., Boca Raton, United States. In Unknown Journal, 0001
These PGs exert their actions through specific high-affinity G protein-coupled receptors named DP1-DP2 (PGD2 receptor 1-PGD2 receptor 2), EP1-EP4 (PGE2 receptor 1-4), FP (PGF2α receptor), IP (PGI2 receptor or prostacyclin receptor), and TP (thromboxane receptor) receptors, respectively.
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