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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ribonuclease, RNase A family, 2

Eosinophil-Derived Neurotoxin, EDN, RNase 2
Top mentioned proteins: MBP, CAN, ACID, HAD, IL-5
Papers on Eosinophil-Derived Neurotoxin
Endothelin-1 downregulates sperm phagocytosis by neutrophils in vitro: a physiological implication in bovine oviduct immunity.
Miyamoto et al., Obihiro, Japan. In J Reprod Dev, Feb 2016
Oviductal contractions are regulated by autocrine/paracrine secretion of several factors, such as prostaglandins (PGs) and endothelin-1 (EDN-1).
Structural basis of substrate specificity in porcine RNase 4.
Acharya et al., Bath, United Kingdom. In Febs J, Feb 2016
However, compared to other members of the RNase A family, including EDN, ECP, and ANG, little is known about the molecular basis of substrate specificity in RNase 4.
Reductions in eosinophil biomarkers by benralizumab in patients with asthma.
Ranade et al., Gaithersburg, United States. In Respir Med, Feb 2016
Blood eosinophils, IL-5, eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), eotaxin/chemokine (C-C motif) 11 (CCL11), eotaxin-2/CCL24, tumor necrosis factor (TNF), and interferon-γ (IFN-γ) were measured at baseline and post-treatment.
Eosinophil localization to the basement membrane zone is autoantibody- and complement-dependent in a human cryosection model of bullous pemphigoid.
Fairley et al., Iowa City, United States. In Exp Dermatol, Jan 2016
15HL-60 expression of granule protein [eosinophil derived neurotoxin (EDN) and eosinophil peroxidase (EPO)] mRNA and their degranulation in vitro was confirmed using RT-PCR and ELISA, respectively.
Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin.
Leonidas et al., Lárisa, Greece. In Bioorg Chem, Dec 2015
Eosinophil derived neurotoxin (EDN) is an eosinophil secretion protein and a member of the Ribonuclease A (RNase A) superfamily involved in the immune response system and inflammatory disorders.
Cytotoxic Activities of Eosinophil Cationic Protein and Eosinophil-derived Neurotoxin: In Silico Analysis.
Pereira et al., Divinópolis, Brazil. In Cancer Genomics Proteomics, Dec 2015
BACKGROUND: Eosinophil cationic protein (ECP) and eosinophil derived-neurotoxin (EDN) are homologous ribonuclease (RNAse) A family proteins.
Serum eosinophil-derived neurotoxin: Correlation with persistent airflow limitation in adults with house-dust mite allergic asthma.
Hashimoto et al., Tokyo, Japan. In Allergy Asthma Proc, Nov 2015
BACKGROUND: The serum level of eosinophil-derived neurotoxin (EDN), a protein present in eosinophil granules, correlates with the severity of childhood asthma.
SMAD Signaling in the Airways of Healthy Versus Asthmatic Rhesus Macaques Highlights a Relationship Between Inflammation and BMPs.
O'Dea et al., Ireland. In Am J Respir Cell Mol Biol, Oct 2015
Eosinophil-derived proteins (EDN, EPO and MBP) induced transient nuclear translocation of membrane-bound BMPRIa.
Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense.
Rosenberg, Bethesda, United States. In Int J Mol Sci, 2014
The eosinophil-derived neurotoxin (EDN/RNase2) and its divergent orthologs, the mouse eosinophil-associated RNases (mEars), are prominent secretory proteins of eosinophilic leukocytes and are all members of the larger family of RNase A-type ribonucleases.
The role of hypoxia-induced genes in ovarian angiogenesis.
Yalu et al., Jerusalem, Israel. In Reprod Fertil Dev, 2012
Special emphasis is given to hypoxia-induced, luteal cell-specific expression of multiple genes (vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF-2), prokineticin receptor 2 (PK-R2), stanniocalcin 1 (STC-1) and endothelin 2 (EDN-2) that participate in the angiogenic process during CL formation.
Antimicrobial activity of human eosinophil granule proteins: involvement in host defence against pathogens.
Batra et al., New Delhi, India. In Crit Rev Microbiol, 2012
The four major eosinophil granule proteins, major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil derived neurotoxin (EDN) and eosinophil peroxidase have been shown to be involved in a number of eosinophil associated functions.
Elevated eosinophil protein X in urine from healthy neonates precedes development of atopy in the first 6 years of life.
Bisgaard et al., Copenhagen, Denmark. In Am J Respir Crit Care Med, 2011
Eosinophil protein X in urine from asymptomatic neonates is a biomarker significantly associated with later development of allergic sensitization, nasal eosinophilia, and eczema during the first 6 years of life
Eosinophil ribonucleases and their cutaneous lesion-forming activity.
Leiferman et al., Rochester, United States. In J Immunol, 2009
ECP and EDN disrupt skin integrity and cause inflammation
Transcriptional regulation of human eosinophil RNase2 by the liver-enriched hepatocyte nuclear factor 4.
Chang et al., Wafangdian, China. In J Cell Biochem, 2009
the roles of the six discrete segments in transcription regulation were investigated and the -350/-329 region (ednR2) was shown to be involved in the regulation of edn expression
Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populations.
Yasuda et al., Fukui, Japan. In Cell Biochem Funct, 2008
In three continental population groups (Asia, Europe, Africa), the angiogenin and RNase 2 genes appear to exhibit markedly less genetic heterogeneity with regard to T195C and A238G (ANG) and C425A (RNASE2) SNPs.
The antipathogen activities of eosinophil cationic protein.
Nogués et al., Barcelona, Spain. In Curr Pharm Biotechnol, 2008
Although eosinophils and ECP are primarily associated with the host defense against nonphagocytosable pathogens, such as helminthic parasites, ECP has also an antibacterial activity, which is not shared by the other, closely-related eosinophil ribonuclease, the eosinophil derived neurotoxin (EDN).
Eosinophil-derived neurotoxin / RNase 2: connecting the past, the present and the future.
Rosenberg, Bethesda, United States. In Curr Pharm Biotechnol, 2008
The eosinophil-derived neurotoxin (EDN, also known as eosinophil protein-X) is best-known as one of the four major proteins found in the large specific granules of human eosinophilic leukocytes.
Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany.
Hoffjan et al., Bochum, Germany. In J Negat Results Biomed, 2007
No variation in genes encoding eosinophil-derived neurotoxin for Atopic dermatitis pathogenesis in this German cohort.
Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction.
Youle et al., Bethesda, United States. In Nat Biotechnol, 1999
We mutated two human ribonucleases-pancreatic RNase (hRNAse) and eosinophil-derived neurotoxin (EDN)-to incorporate cysteine residues at putative sites of close contact to RI, but distant from the catalytic sites.
Rapid evolution of a unique family of primate ribonuclease genes.
Gonzalez et al., Bethesda, United States. In Nat Genet, 1995
We have traced the rapid molecular evolution of eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), two host defense proteins that are members of the mammalian ribonuclease gene family.
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