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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

IKAROS family zinc finger 4

EOS
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, IL-5, V1a
Papers using EOS antibodies
Unique properties of RV in an in vitro model of asthma exacerbation
Supplier
Adamko Darryl et al., In Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 2009
... EOS cysteinyl-leukotriene (Cys-LT) release was measured by ELISA (Cayman Chemical) ...
The cladistics and higher classification of the Pimpliformes (Hymenoptera: Ichneumonidae).
Supplier
Broad Gavin R. et al., In ZooKeys, 1997
... Images of specimens in BMNH were taken with a Canon EOS 450D digital camera attached to a Leica MZ12 stereomicroscope and with ...
Papers on EOS
Evidence for synergistic activity of plant-derived essential oils against fungal pathogens of food.
New
Lacroix et al., Québec, Canada. In Food Microbiol, Feb 2016
The antifungal activities of eight essential oils (EOs) namely basil, cinnamon, eucalyptus, mandarin, oregano, peppermint, tea tree and thyme were evaluated for their ability to inhibit growth of Aspergillus niger, Aspergillus flavus, Aspergillus parasiticus and Penicillium chrysogenum.
Treg stability: to be or not to be.
Review
New
Vignali et al., Pittsburgh, United States. In Curr Opin Immunol, Feb 2016
Recent work suggests that the establishment and stability of Tregs is mediated by a number of mechanisms besides Foxp3 expression, such as epigenetic modifications, Foxo1/3a localization, expression of Eos and signaling via Neuropilin-1.
[(11)C]NS9531, [(11)C]NS9762 and [(11)C]NS6417, specific SERT tracers: pre-clinical evaluation in pigs and optimization of synthesis conditions using [(11)C]methyl triflate.
New
Någren et al., Odense, Denmark. In Nucl Med Biol, Jan 2016
Residual precursor amounts in final products could be significantly reduced by the use of [(11)C]methyl triflate, <0.2μg compared with <10μg, calculated for a 300MBq injection at 20minutes EOS.
Monoclonal antibodies: the new magic bullets for allergy.
Review
New
Levi-Schaffer et al., Jerusalem, Israel. In Br J Pharmacol, Jan 2016
They are characterized by tissue resident mast cell activation and consequent tissue infiltration and stimulation of several inflammatory cells and predominantly of eosinophils (Eos).
Optimising musculoskeletal care for patients with haemophilia.
Review
New
Santagostino et al., Toronto, Canada. In Eur J Haematol, Dec 2015
These agents also prevent bleeding during elective orthopaedic surgery (EOS) in this patient population.
High frequency of T helper type 9 cells in Chinese patients with allergic rhinitis.
New
Hong et al., Chongqing, China. In Asian Pac J Allergy Immunol, Dec 2015
Disease severity was assessed by rhino-conjunctivitis quality of life questionnaires (RQLQ), visual analog scale scores (VAS), and peripheral eosinophils (EOS) count.
Possible role of a dysregulation of the endogenous opioid system in antisocial personality disorder.
Review
New
Wedekind et al., Göttingen, Germany. In Hum Psychopharmacol, Nov 2015
A recent theory has proposed that a dysfunction of the endogenous opioid system (EOS) underlies the neurobiology of borderline personality disorder (BPD).
Repellent and Anti-quorum Sensing Activity of Six Aromatic Plants Occurring in Colombia.
New
Olivero-Verbel et al., In Nat Prod Commun, Oct 2015
Essential oils (EOs) are widely used as biopesticides and to control bacterial infections.
[Effect of formaldehyde inhalation on allergic rhinitis in mice].
New
Xu et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, Aug 2015
The nasal mucosa HE staining showed that the density of EOS increased simultaneously in formaldehyde exposure allergic rhinitis groups.
Fixation-resistant photoactivatable fluorescent proteins for CLEM.
New
Impact
Looger et al., United States. In Nat Methods, Mar 2015
Here we report engineered variants of the photoconvertible Eos fluorescent protein that fluoresce and photoconvert normally in heavily fixed (0.5-1% OsO4), plastic resin-embedded samples, enabling correlative super-resolution fluorescence imaging and high-quality electron microscopy.
First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors.
Impact
Drevs et al., Tübingen, Germany. In J Clin Oncol, 2015
Response was monitored by computed tomography/magnetic resonance imaging at baseline, at the end of treatment (EoT), and at final follow-up (EoS), and was assessed according to RECIST.
Autoinflammatory granulomatous diseases: from Blau syndrome and early-onset sarcoidosis to NOD2-mediated disease and Crohn's disease.
Review
Punzi et al., Padova, Italy. In Rmd Open, 2014
Among those, Blau syndrome (BS) and early-onset sarcoidosis (EOS) have been identified as familial and sporadic phenotypes of the same non-caseating granulomatous form.
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Impact
Benoist et al., Boston, United States. In Nat Immunol, 2012
Enforced expression of Helios or Xbp1 elicited distinct signatures, but Eos, IRF4, Satb1, Lef1 and GATA-1 elicited exactly the same outcome, acting in synergy with Foxp3 to activate expression of most of the T(reg) cell signature, including key transcription factors, and enhancing occupancy by Foxp3 at its genomic targets.
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.
Impact
Vignali et al., Memphis, United States. In Immunity, 2012
Foxp3(gfp) was unable to interact with the histone acetyltransferase Tip60, the histone deacetylase HDAC7, and the Ikaros family zinc finger 4, Eos, which led to reduced Foxp3 acetylation and enhanced K48-linked polyubiquitylation.
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
Impact
Christiano et al., New York City, United States. In Nature, 2010
Here we show an association with genomic regions containing several genes controlling the activation and proliferation of regulatory T cells (T(reg) cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region.
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.
Impact
GeneRIF
Pardoll et al., Baltimore, United States. In Science, 2009
study identified Eos as a critical mediator of Foxp3-dependent gene silencing in CD4+ regulatory T cells (Tregs); Eos interacts directly with Foxp3 and induces chromatin modifications that result in gene silencing in Tregs
Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors.
GeneRIF
Ostrowski et al., Columbus, United States. In Mol Cell Biol, 2007
Data suggest that Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitor cells.
A novel serine protease predominately expressed in macrophages.
GeneRIF
Andrade-Gordon et al., United States. In Biochem J, 2003
highly expressed in spleen and moderately expressed in intestine, colon, lung and brain
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