Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts.
Bonn, Germany. In Cell Stem Cell, Dec 2015
Here, we show that transient expression of Tfap2c, Gata3, Eomes, and Ets2 is sufficient to reprogram mouse embryonic fibroblasts and post-natal tail-tip-derived fibroblasts into induced TSCs (iTSCs) and surmount the epigenetic barrier separating somatic from extra-embryonic lineages.
Molecular biology of the stress response in the early embryo and its stem cells.
Detroit, United States. In Adv Exp Med Biol, 2014
Some of the transcription factors (TFs) that are most important in the stress response are JunC, JunB, MAPKAPs, ATF4, XBP1, Oct1, Oct4, HIFs, Nrf2/KEAP, NFKB, MT1, Nfat5, HSF1/2 and potency-maintaining factors Id2, Cdx2, Eomes, Sox2, Nanog, Rex1, and Oct4.