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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Nidogen 1

entactin, nidogen-1, NID, Nidogen
This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: fibronectin, CAN, HAD, ACID, CD45
Papers using entactin antibodies
Non-Smad pathways in TGF-beta signaling
Supplier
Spessotto Paola et al., In The Journal of Cell Biology, 2008
... Rabbit anti-Ki67, Keratin 6, laminin-5, collagen IV, and entactin/nidogen antibodies were purchased from Abcam.
Papers on entactin
Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation.
New
Miosge et al., Göttingen, Germany. In Am J Pathol, Feb 2016
The aim of this study was to investigate the role of laminins and nidogen-2 in osteoarthritis (OA) and their potential to support chondrogenic differentiation.
Impaired primary mouse myotube formation on crosslinked type I collagen films is enhanced by laminin and entactin.
New
Daamen et al., Nijmegen, Netherlands. In Acta Biomater, Feb 2016
In this study we investigated the differentiation capacity of primary murine myoblasts on type I collagen films either untreated or modified with elastin, laminin, type IV collagen, laminin/entactin complex, combinations thereof, and Matrigel as a positive control.
Differential protein expression and basal lamina remodeling in human heart failure.
New
Westfall et al., Ann Arbor, United States. In Proteomics Clin Appl, Feb 2016
RESULTS: Differential protein expression of collagen IV, laminin α2, and nidogen-1 indicated BL remodeling develops in F versus NF hearts Periodic disruption of cardiac myocyte BL accompanied this process in F, but not NF heart.
The corneal fibrosis response to epithelial-stromal injury.
Review
New
Wilson et al., Cleveland, United States. In Exp Eye Res, Jan 2016
A major discovery that has contributed to our understanding of haze development is that keratocytes and corneal fibroblasts produce critical EBM components, such as nidogen-1, nidogen-2 and perlecan, that are essential for complete regeneration of a normal EBM once laminin secreted by epithelial cells self-polymerizes into a nascent EBM.
Proteomic Discovery and Development of a Multiplexed Targeted MRM-LC-MS/MS Assay for Urine Biomarkers of Extracellular Matrix Disruption in Mucopolysaccharidoses I, II, and VI.
New
Mills et al., London, United Kingdom. In Anal Chem, Jan 2016
Collagen type Iα, fatty-acid-binding-protein 5, nidogen-1, cartilage oligomeric matrix protein, and insulin-like growth factor binding protein 7 concentrations were elevated in severe MPS I and II groups.
Host cell protein impurities in chromatographic polishing steps for monoclonal antibody purification.
New
Lenhoff et al., Newark, United States. In Biotechnol Bioeng, Dec 2015
A relatively large sub-population of HCP impurities was found to co-elute or associate with mAbs in each polishing column, but only a small population of HCPs - including lipoprotein lipase, chrondroitin sulfate proteoglycan 4, nidogen-1 and SPARC - were identified as difficult to remove across an entire downstream mAb process.
Spontaneous Helical Structure Formation in Laminin Nanofibers.
New
Feinberg et al., Pittsburgh, United States. In J Mater Chem B Mater Biol Med, Nov 2015
Specifically, we compared laminin 111 with varying degrees of purity and with and without entactin to determine whether these changes alter biophysical properties.
Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy.
New
Carare et al., Southampton, United Kingdom. In Biochim Biophys Acta, Sep 2015
Results showed that nidogen 2 (entactin) increases with age and decreases in CAA.
Differential expression of epithelial basement membrane components nidogens and perlecan in corneal stromal cells in vitro.
Wilson et al., São Paulo, Brazil. In Mol Vis, 2014
In vitro model systems were used to explore the expression of EBM components nidogen-1, nidogen-2, and perlecan that are the primary components in the lamina lucida and the lamina densa that defectively regenerate in corneas with stromal opacity after in -9.0 D photorefractive keratectomy (PRK).
Vitamin a deficiency and alterations in the extracellular matrix.
Review
Timoneda et al., Burjassot, Spain. In Nutrients, 2014
Extracellular matrix proteins are among those whose synthesis is known to be modulated by vitamin A. Retinoic acid, the main biologically active form of vitamin A, influences the expression of collagens, laminins, entactin, fibronectin, elastin and proteoglycans, which are the major components of the extracellular matrix.
[Apoptosis of alveolar lymphocytes. Part 1: pathways of lymphocyte apoptosis].
Review
Giżycka et al., In Pneumonol Alergol Pol, 2013
The specific apoptotic processes, i.e. activation induced cell death (AICD) and neglect induced death (NID), are types of extrinsic and intrinsic pathways, respectively.
Role of apoptosis-inducing factor (Aif) in the T cell lineage.
Review
Rath et al., New Delhi, India. In Indian J Med Res, 2013
In peripheral mature T cells, Aif deficiency leads to an increased susceptibility of T cell blasts to activation induced cell death (AICD), possibly mediated by its antioxidant function, and decreased sensitivity to neglect-induced death (NID).
[Mechanisms of programmed cell death of effector T lymphocytes].
Review
Kopiński et al., Toruń, Poland. In Postepy Hig Med Dosw (online), 2012
Two main pathways of effector T cell PCD are discussed in the review: activation induced cell death (AICD), which is a form of extrinsic apoptosis, and neglect-induced death (NID), which is an intrinsic one.
Absence of the basement membrane component nidogen 2, but not of nidogen 1, results in increased lung metastasis in mice.
GeneRIF
Nischt et al., Köln, Germany. In J Histochem Cytochem, 2012
show that loss of nidogen 2, but not of nidogen 1, promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane
Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.
GeneRIF
Han et al., Boston, United States. In Hum Mol Genet, 2011
NID1 gene is a biologically plausible locus for nevogenesis and melanoma development
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
GeneRIF
Nischt et al., Köln, Germany. In J Biol Chem, 2011
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitability.
GeneRIF
Köhling et al., Köln, Germany. In Hippocampus, 2010
This study demonstrates that nidogen-1 is essential for maintenance of normal hippocampal excitability and synaptic plasticity.
Impaired wound healing in mice lacking the basement membrane protein nidogen 1.
GeneRIF
Nischt et al., Köln, Germany. In Matrix Biol, 2010
Results suggest a non-structural role for nidogen 1 in wound repair.
Positioning of longitudinal nerves in C. elegans by nidogen.
Impact
Wadsworth et al., United States. In Science, 2000
Although members of the nidogen (entactin) protein family are structural components of basement membranes, we find that nidogen is not required for basement membrane assembly in the nematode Caenorhabditis elegans.
Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon.
Impact
Korsmeyer et al., Saint Louis, United States. In Nat Med, 1997
Enx-/- mice provide a model for human neuronal intestinal dysplasia (NID), in which myenteric neuronal hyperplasia and megacolon are seen.
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