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Endosulfine alpha

ENSA, alpha-Endosulfine
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, PP2A, CAN, CDC2, KCNE1
Papers on ENSA
The mitotic PP2A regulator ENSA/ARPP-19 is remarkably conserved across plants and most eukaryotes.
Moorhead et al., Calgary, Canada. In Biochem Biophys Res Commun, Apr 2015
PP2A containing the B55 subunit is a key regulator of mitosis and must be inhibited by phosphorylated α-endosulfine (ENSA) or cyclic AMP-regulated 19 kDa phosphoprotein (ARPP-19) to allow passage through mitosis.
Model scenarios for switch-like mitotic transitions.
Novak et al., Oxford, United Kingdom. In Febs Lett, Apr 2015
To facilitate rapid accumulation of Cdk1-phosphorylated substrate proteins, the Cdk1 counter-acting phosphatase, PP2A-B55 is inhibited during M phase by stoichiometric inhibitors (ENSA and Arpp19).
Regulation of α-endosulfine, an inhibitor of protein phosphatase 2A, by multisite phosphorylation.
Mochida, Kumamoto, Japan. In Febs J, 2014
α-endosulfine (ENSA)/cyclic AMP-regulated 19 kDa phosphoprotein (ARPP-19) family proteins phosphorylated at S67 by Greatwall kinase bind and inhibit PP2A-B55.
ENSA expression correlates with attenuated tumor propagation in liver cancer.
Hsiao et al., Taiwan. In Biochem Biophys Res Commun, 2014
Endosulfine alpha (ENSA) is an endogenous ligand of sulfonylurea receptor that was reported to be associated with an ATP-dependent potassium channel that controls insulin release and the onset of type 2 diabetes.
α-endosulfine (ENSA) regulates exit from prophase I arrest in mouse oocytes.
Evans et al., Baltimore, United States. In Cell Cycle, 2013
ENSA (α-endosulfine) and ARPP19 (cAMP-regulated phosphoprotein-19) have emerged as regulators of M-phase, with function in inhibition of protein phosphatase 2A (PP2A) activity.
Comparative genetic analysis of PP2A-Cdc55 regulators in budding yeast.
Yoshida et al., Waltham, United States. In Cell Cycle, 2013
In animal cells, highly conserved ENSA/ARPP-19 family proteins bind and inhibit PP2A-B55 activity for mitotic entry.
The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation.
Barr et al., Oxford, United Kingdom. In Mol Cell, 2013
Instead, the PP2A-B55α/ENSA/Greatwall (BEG) pathway controls the human Ase1p ortholog PRC1.
The Greatwall kinase: a new pathway in the control of the cell cycle.
Castro et al., Montpellier, France. In Oncogene, 2013
Activated Gwl phosphorylates its substrates cAMP-regulated phospho protein 19 (Arpp19) and α-endosulfine (ENSA), promoting their binding to and the inhibition of PP2A.
Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.
Rao et al., India. In Int J Diabetes Dev Ctries, 2010
These 50 functional genes are responsible for diabetic nephropathy; of these 50, some of the genes which are more expressed and responsible are AGXT: Alanine-glyoxylate aminotransferase, RHOD: Ras homolog gene family, CAPN6: Calpain 6, EFNB2: Ephrin-B2, ANXA7: Annexin A7, PEG10: Paternally expressed 10, DPP4: Dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2), ENSA: Endosulfine alpha, IGFBP2: Insulin-like growth factor binding protein 2, 36kDa, CENPB: Centromere protein B, 80kDa, MLL3: Myeloid/lymphoid or mixed-lineage leukemia 3, BDNF: Brain-derived neurotrophic factor, EIF4A2: Eukaryotic translation initiation factor 4A, isoform 2, PPP2R1A: Protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform.
Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha.
Rienstra et al., Urbana, United States. In Biochemistry, 2008
Endosulfine-alpha (ENSA) is a 121-residue cAMP-regulated phosphoprotein, originally identified as an endogenous regulator of ATP-sensitive potassium channels.
alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila.
Drummond-Barbosa et al., Nashville, United States. In Development, 2008
Finally, germline-specific expression of the human alpha-endosulfine ENSA rescues the endos mutant meiotic defects and infertility, and alpha-endosulfine is expressed in mouse oocytes, suggesting potential conservation of its meiotic function.
Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF.
Caceres et al., Edinburgh, United Kingdom. In Plos One, 2007
We demonstrate that ectopic expression of SF2/ASF regulates the splicing and polysome association of transcripts derived from the SFRS1, PABC1, NETO2 and ENSA genes.
Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy.
George et al., Urbana, United States. In J Biol Chem, 2007
To verify that the screen identifies proteins with specificity for helical AS, we further characterized one of these candidates, endosulfine alpha (ENSA), a small cAMP-regulated phosphoprotein implicated in the regulation of insulin secretion but also expressed abundantly in the brain.
Fibrolamellar carcinomas show overexpression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways.
Torbenson et al., Vellore, India. In Hum Pathol, 2007
Of 114 total genes found overexpressed in common among all primary and metastatic tumors, 11 of 114 genes were located on chromosome 1q: ARF1, CD46, CNIH4, ENSA, FH, NICE-3, PSMB4, RGS2, RGS5, TIMM17A, and UFC1.
Rat mesangial alpha-endosulfine.
Szamosfalvi et al., Detroit, United States. In Kidney Int, 2004
ENSA and alpha-endosulfine are expressed in glomeruli and mesangial cells, and gene and protein expression are up-regulated by a high glucose environment.
Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion.
Elbein et al., Little Rock, United States. In Mol Genet Metab, 2004
We mapped ENSA in silico to chromosome 1q21 near a confirmed type 2 diabetes susceptibility locus, and derived the genomic structure of four exons and three introns.
The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians.
Prochazka et al., Phoenix, United States. In Mol Genet Metab, 2004
The ENSA gene on 1q21 produces several alternatively spliced transcripts, and is located within a region linked with T2DM in diverse populations including the Pima Indians
Gene expression of alpha-endosulfine in the rat brain: correlative changes with aging, learning and stress.
Zhao et al., Rockville, United States. In J Neurochem, 2003
results suggest that alpha-endosulfine gene expression is differentially regulated by distinct brain processes involving excitatory neuronal activities
Localization of alpha-endosulphine in pancreatic somatostatin delta cells and expression during rat pancreas development.
Virsolvy et al., Montpellier, France. In Diabetologia, 2002
localization in pancreatic somatostatin delta cells and expression during rat pancreas development
alpha-Endosulfine, a new entity in the control of insulin secretion.
Blache et al., Montpellier, France. In Cell Mol Life Sci, 1999
In this review, we describe the discovery, isolation, cloning, and biological features of the high-molecular-mass form, alpha-endosulfine, and discuss its possible role in the physiology of the beta cell as well as in pathology.
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