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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Proenkephalin

Enkephalin, Met-enkephalin, proenkephalin, Leu-enkephalin
neuropeptide hormone; plays a role in the responses to stress and pain perception [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, HAD, Neuropeptide, ACID, proenkephalin
Papers using Enkephalin antibodies
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.
Supplier
Najbauer Joseph, In PLoS ONE, 2006
... PKC-α, ERK1/2, synapsin-IIa and Met/Liu enkephalin were obtained from Cell Signaling Technology (MA, USA) ...
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization.
Supplier
Mucke Lennart et al., In Nature neuroscience, 1999
... Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's ...
Papers on Enkephalin
An antihypertensive opioid: Biphalin, a synthetic non-addictive enkephalin analog decreases blood pressure in spontaneously hypertensive rats.
New
Sadowski et al., Warsaw, Poland. In Pharmacol Rep, Feb 2016
We examined cardiovascular effects of biphalin, a potentially non-addictive dimeric enkephalin analog, an agonist of opioid μ and δ receptors.
Dual projections of single orexin- or CART-immunoreactive, lateral hypothalamic neurons to the paraventricular thalamic nucleus and nucleus accumbens shell in the rat: Light microscopic study.
New
Lee et al., Seoul, South Korea. In Brain Res, Feb 2016
At the light microscopic level, ORX (or CART) terminals formed close appositions to choline acetyltransferase (ChAT)-, glutamate decarboxylase (GAD)-, or enkephalin (Enk)-immunoreactive neuronal elements in the AcbSh.
Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive Activity.
New
Marvizón et al., Los Angeles, United States. In J Neurosci, Feb 2016
We further demonstrated that suppression of hyperalgesia by MORs was due to their constitutive activity because of the following: (1) CFA-induced hyperalgesia was reinstated by the MOR inverse agonist naltrexone (NTX), but not by its neutral antagonist 6β-naltrexol; (2) pro-enkephalin, pro-opiomelanocortin, and pro-dynorphin KO mice showed recovery from hyperalgesia and reinstatement by NTX; (3) there was no MOR internalization during remission; (4) MORs immunoprecipitated from the spinal cord during remission had increased Ser(375) phosphorylation; and (5) electrophysiology recordings from dorsal root ganglion neurons collected during remission showed constitutive MOR inhibition of calcium channels.
Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease.
New
Kimab et al., Wŏnju, South Korea. In Peptides, Feb 2016
An endogenous peptide for δ-opioid receptor (DOPr), Leu-enkephalin (L-ENK), is expressed in the skin and its expression is altered in pathological conditions.
VUV action spectroscopy of protonated leucine-enkephalin peptide in the 6-14 eV range.
New
Milosavljević et al., Belgrade, Serbia. In J Chem Phys, Jan 2016
We have studied the Vacuum Ultraviolet (VUV) photodissociation of gas-phase protonated leucine-enkephalin peptide ion in the 5.7 to 14 eV photon energy range by coupling a linear quadrupole ion trap with a synchrotron radiation source.
60 YEARS OF POMC: POMC: an evolutionary perspective.
Review
New
Cerdá-Reverter et al., Spain. In J Mol Endocrinol, Jan 2016
This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodinorphyn (PDYN) and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event.
Delta opioid agonists: a concise update on potential therapeutic applications.
Review
New
Raffa et al., University City, United States. In J Clin Pharm Ther, Apr 2015
Among the endogenous opioid peptides (endomorphins, enkephalins, dynorphins and nociception/orphanin FQ) derived from the precursors encoded by four genes (PNOC, PENK, PDYN and POMC) are the pentapeptides Met-enkephalin (Tyr-Gly-Gly-Phe-Met) and Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu).
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
New
Impact
Artis et al., New York City, United States. In Nature, Apr 2015
We found that ILC2s produce methionine-enkephalin peptides that can act directly on adipocytes to upregulate Ucp1 expression in vitro and that promote beiging in vivo.
Current gene therapy using viral vectors for chronic pain.
Review
Hao et al., Pittsburgh, United States. In Mol Pain, 2014
Drs Goins and Kinchington group describes a strategy to use the replication defective HSV vector to deliver two different gene products (enkephalin and TNF soluble receptor) for the treatment of post-herpetic neuralgia.
Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human.
Review
Hrabovszky et al., Budapest, Hungary. In Front Neurosci, 2014
In contrast, dynorphin described in KP neurons of rodents and sheep is found rarely in KP cells of human males and postmenopausal females.
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Review
Impact
Breit et al., München, Germany. In Pharmacol Rev, 2014
However, several distinct peptides and amino acids are discussed as potential ligands, including β-alanine, angiotensin-(1-7), alamandine, GABA, cortistatin-14, and cleavage products of proenkephalin, pro-opiomelanocortin, prodynorphin, or proneuropeptide-FF-A.
Dynorphins regulate fear memory: from mice to men.
GeneRIF
Zimmer et al., Bonn, Germany. In J Neurosci, 2012
Human volunteers bearing the T allele of PDYN (prodynorphin) show reduced fear extinction.
Lateralized response of dynorphin a peptide levels after traumatic brain injury.
GeneRIF
Bakalkin et al., Uppsala, Sweden. In J Neurotrauma, 2012
trauma may reveal a lateralization in the mechanism mediating the response of Dyn A-expressing neuronal networks in the brain
Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction.
GeneRIF
Lohoff et al., Philadelphia, United States. In Genes Brain Behav, 2012
These data show that polymorphisms in PDYN are associated with opioid addiction in European Americans and provide further evidence that these risk variants may be more relevant in females.
Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters.
GeneRIF
Hook et al., San Diego, United States. In J Biol Chem, 2012
Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases.
New roles of carboxypeptidase E in endocrine and neural function and cancer.
Review
Impact
Loh et al., Bethesda, United States. In Endocr Rev, 2012
Carboxypeptidase E (CPE) or carboxypeptidase H was first discovered in 1982 as an enkephalin-convertase that cleaved a C-terminal basic residue from enkephalin precursors to generate enkephalin.
2',6'-dimethylphenylalanine: a useful aromatic amino Acid surrogate for tyr or phe residue in opioid peptides.
Review
Ambo et al., Sendai, Japan. In Int J Med Chem, 2011
The usefulness of an artificial amino acid residue 2',6'-dimethylphenylalanine (Dmp) was investigated as an aromatic amino acid surrogate for several opioid peptides, including enkephalin, dermorphin, deltorphin, endomorphin, dynorphin A, and nociceptin peptides.
Mutations in the PDYN gene (SCA23) are not a frequent cause of dominant ataxia in Central Europe.
GeneRIF
Schöls et al., In Clin Genet, 2011
findings clearly indicate a very low frequency of spinocerebellar ataxia type 23 (SCA23) caused by PDYN mutations in Germany
Reward processing by the opioid system in the brain.
Review
Impact
Kieffer et al., Illkirch-Graffenstaden, France. In Physiol Rev, 2009
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin.
Erratum.
Impact
In Science, 1981
In the report "Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition" by G. Patey et al. (5 June, p. 1153), Fig. 1B was labeled incorrectly.
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