Papers using
Enkephalin
antibodies
Papers on
Enkephalin
Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive Activity.Marvizón et al., Los Angeles, United States. In J Neurosci, Feb 2016
We further demonstrated that suppression of hyperalgesia by MORs was due to their constitutive activity because of the following: (1) CFA-induced hyperalgesia was reinstated by the MOR inverse agonist naltrexone (NTX), but not by its neutral antagonist 6β-naltrexol; (2) pro-enkephalin, pro-opiomelanocortin, and pro-dynorphin KO mice showed recovery from hyperalgesia and reinstatement by NTX; (3) there was no MOR internalization during remission; (4) MORs immunoprecipitated from the spinal cord during remission had increased Ser(375) phosphorylation; and (5) electrophysiology recordings from dorsal root ganglion neurons collected during remission showed constitutive MOR inhibition of calcium channels.
60 YEARS OF POMC: POMC: an evolutionary perspective.Cerdá-Reverter et al., Spain. In J Mol Endocrinol, Jan 2016
This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodinorphyn (PDYN) and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event.
Current gene therapy using viral vectors for chronic pain.Hao et al., Pittsburgh, United States. In Mol Pain, 2014
Drs Goins and Kinchington group describes a strategy to use the replication defective HSV vector to deliver two different gene products (enkephalin and TNF soluble receptor) for the treatment of post-herpetic neuralgia.
Pharmacology and signaling of MAS-related G protein-coupled receptors.Breit et al., München, Germany. In Pharmacol Rev, 2014
However, several distinct peptides and amino acids are discussed as potential ligands, including β-alanine, angiotensin-(1-7), alamandine, GABA, cortistatin-14, and cleavage products of proenkephalin, pro-opiomelanocortin, prodynorphin, or proneuropeptide-FF-A.
2',6'-dimethylphenylalanine: a useful aromatic amino Acid surrogate for tyr or phe residue in opioid peptides.Ambo et al., Sendai, Japan. In Int J Med Chem, 2011
The usefulness of an artificial amino acid residue 2',6'-dimethylphenylalanine (Dmp) was investigated as an aromatic amino acid surrogate for several opioid peptides, including enkephalin, dermorphin, deltorphin, endomorphin, dynorphin A, and nociceptin peptides.
Reward processing by the opioid system in the brain.Kieffer et al., Illkirch-Graffenstaden, France. In Physiol Rev, 2009
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin.
Erratum.In Science, 1981
In the report "Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition" by G. Patey et al. (5 June, p. 1153), Fig. 1B was labeled incorrectly.