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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, AGE, POLYMERASE
Papers on Engl
Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms.
Castro et al., Ann Arbor, United States. In Methods Mol Biol, Dec 2015
months post diagnosis (Stupp et al., N Engl J Med 352(10): 987-996, 2005).
Cancer Gene Profiling for Response Prediction.
Jo et al., Göttingen, Germany. In Methods Mol Biol, Dec 2015
Over the past few years, microarray technology has emerged as a central tool in addressing pertinent clinical questions, the answers to which are critical for the realization of a personalized genomic medicine, in which patients will be treated based on the biology of their tumor and their genetic profile (Quackenbush, N Engl J Med 354:2463-72, 2006; Jensen et al., Curr Opin Oncol 18:374-380, 2006; Bol and Ebner, Pharmacogenomics 7:227-235, 2006; Nevins and Potti, Nat Rev Genet 8:601-609, 2007).
Heterozygous Monocarboxylate Transporter 1 (MCT1, SLC16A1) Deficiency as a Cause of Recurrent Ketoacidosis.
Sass et al., Perth, Australia. In Jimd Rep, Dec 2015
UNASSIGNED: We describe two half-siblings with monocarboxylate transporter 1 (MCT1, SLC16A1) deficiency, a defect on ketone body utilization, that has only recently been identified (van Hasselt et al., N Engl J Med, 371:1900-1907, 2014) as a cause for recurrent ketoacidoses.
Beyond vascular inflammation--recent advances in understanding atherosclerosis.
Ley et al., Los Angeles, United States. In Cell Mol Life Sci, Oct 2015
August Hirschwald Verlag Berlin, [1871]), atherosclerosis was recognized as a chronic inflammatory disease in 1986 (New Engl J Med 314:488-500, 1986).
Eosinophilic granulomatosis with polyangiitis (EGPA) and PRES: a case-based review of literature in ANCA-associated vasculitides.
Granata et al., Roma, Italy. In Rheumatol Int, Sep 2015
Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological entity described for the first time by Hinchey et al. (N Engl J Med 334(8):494-500, 1996) and characterized by MRI findings of reversible subcortical vasogenic edema predominantly in the white matter of posterior cerebral lobes.
[Genetic variants in C5 and poor response to eculizumab].
Nishimura, Ōsaka, Japan. In Rinsho Ketsueki, Jul 2015
This review summarizes the presentation entitled "Genetic variants in C5 and poor response to eculizumab" (N Engl J Med. 2014; 370: 632-639), given at Symposium 3 entitled "Basic and clinical topics on red blood cell membrane", during the 76th Annual Meeting of the Japanese Society of Hematology.
[The C5 gene polymorphism in patients with PNH].
Kanakura et al., Ōsaka, Japan. In Rinsho Ketsueki, Feb 2015
This review is a commentary on an article entitled "Genetic variants in C5 and poor response to eculizumab" (N Engl J Med. 2014; 370: 632-639).
Correlation between proinflammatory role of a lectin from Typhonium giganteum Engl. and macrophage.
Zhang et al., Nanjing, China. In Int J Clin Exp Pathol, 2014
PURPOSE: To analyze the correlation between proinflammatory effects of a lectin from Typhonium giganteum Engl.
Redox proteomics: from bench to bedside.
Ckless, Plattsburgh, United States. In Adv Exp Med Biol, 2013
These modifications include phosphorylation, glycosylation, S-nitrosylation, acetylation, lipidation, among others (Angew Chem Int Ed Engl 44(45):7342-7372, 2005).
Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair.
Szczesny et al., Galveston, United States. In J Biol Chem, 2011
EXOG depletion induces persistent SSBs in the mtDNA, enhances ROS levels, and causes apoptosis in normal cells but not in mt genome-deficient rho0 cells.
EXOG, a novel paralog of Endonuclease G in higher eukaryotes.
Meiss et al., Warsaw, Poland. In Nucleic Acids Res, 2008
Human endonuclease G-like-1 is a dimeric mitochondrial enzyme that displays 5'-3' exonuclease activity and further differs from EndoG in substrate specificity
Genetic association of single nucleotide polymorphisms in endonuclease G-like 1 gene with type 2 diabetes in a Japanese population.
Itakura et al., Tokushima, Japan. In Diabetologia, 2007
ENDOGL1 is a candidate disease-susceptibility gene for type 2 diabetes in a Japanese population
Optimised glucocorticoid therapy: the sharpening of an old spear.
Lipworth et al., Berlin, Germany. In Lancet, 2005
STARTING POINT: Last year, Mary Leonard and colleagues studied 60 children and adolescents with nephrotic syndrome intermittently treated with high-dose glucocorticoids (N Engl J Med 2004; 351: 868-75).
Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss?
Harper et al., Frederiksberg, Denmark. In Lancet, 2004
Two groups have reported longer-term randomised studies that compared instruction in the low-carbohydrate diet with a low-fat calorie-reduced diet in obese patients (N Engl J Med 2003; 348: 2082-90; Ann Intern Med 2004; 140: 778-85).
Stem-cell consequences of embryo epigenetic defects.
Young et al., Nottingham, United Kingdom. In Lancet, 2004
Chad Cowan and colleagues (N Engl JMed 2004; 350: 1353-56) produced 17 new lines from embryos supernumerary to infertility treatments.
Targeted treatments for symptom domains in child and adolescent autism.
Yeh et al., New York City, United States. In Lancet, 2003
J McCracken and colleagues (N Engl J Med 2000; 347: 314-21) showed that the atypical antipsychotic risperidone reduced serious behavioural problems, such as tantrums, aggression, or self-injury in children with autism and in children with below-average intelligence quotients.
Non-steroidal anti-inflammatory drugs and molecular carcinogenesis of colorectal carcinomas.
Kleibeuker et al., Groningen, Netherlands. In Lancet, 2003
STARTING POINT: Two recently reported randomised placebo-controlled trials show a chemopreventive effect of aspirin in populations other than those with FAP (Robert Sandler and colleagues, N Engl J Med 2003; 348: 883-90; John Baron and colleagues, N Engl J Med 2003; 348: 891-99).
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