Endothelin-1 and antiangiogenesis.
Bronkhorstspruit, South Africa. In Am J Physiol Regul Integr Comp Physiol, Nov 2015
Studies in eNOS-deficient mice and pharmacological treatment with endothelin receptor blockers and sildenafil indicate that an activated endothelin system, rather than NO suppression mediates the side effects of angiogenesis inhibitors.
The pharmacological treatment of pulmonary arterial hypertension.
In Pharmacol Rev, 2012
Advances in understanding the pathobiology over the last 2 decades have led to therapies (endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, and prostacyclins or analogs) initially directed at reversing the pulmonary vasoconstriction and more recently directed toward reversing endothelial cell dysfunction and smooth muscle cell proliferation.