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Endothelin receptor type A

endothelin receptor, ETA
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: endothelin-1, ETB, HAD, CAN, Phosphodiesterase
Papers on endothelin receptor
Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43.
New
Dai et al., Nanjing, China. In Acta Pharmacol Sin, Feb 2016
Serum hormone levels were measured, and the expression of endothelin receptor A (ETA), connexin 43 (Cx43) and other proteins in testes was detected.
Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia.
New
Gulati, Downers Grove, United States. In Curr Neuropharmacol, Feb 2016
UNASSIGNED: The ET family consists of three isopeptides (ET-1, ET-2 and ET-3) that produce biological actions by acting on two types of receptors (ETA and ETB).
Endothelin-1 downregulates sperm phagocytosis by neutrophils in vitro: a physiological implication in bovine oviduct immunity.
New
Miyamoto et al., Obihiro, Japan. In J Reprod Dev, Feb 2016
EDN-1 suppressed mRNA expression of EDN-1 and ETB but not ETA receptors in PMNs, suggesting the ETB receptor-mediated pathway.
Treatment persistence among patients with immune-mediated rheumatic disease newly treated with subcutaneous TNF-alpha inhibitors and costs associated with non-persistence.
New
Kachroo et al., Stockholm, Sweden. In Rheumatol Int, Feb 2016
Patients were identified through filled prescriptions for adalimumab (ADA), etanercept (ETA), certolizumab pegol (CZP), and golimumab (GLM) between 5/6/2010 and 12/31/2012 from the Swedish Prescribed Drug Register.
Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide.
Review
New
Leach et al., Buffalo, United States. In Semin Perinatol, Feb 2016
Oral pulmonary vasodilators such as endothelin receptor antagonist bosentan and phosphodiesterase-5 inhibitors such as sildenafil and tadalafil are used both during acute and chronic phases of PPHN.
The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia.
Review
New
Danser et al., Rotterdam, Netherlands. In Ther Adv Cardiovasc Dis, Feb 2016
Moreover, studies in animal models representative of PE, have shown that endothelin receptor blockers prevent the development of this disease.
Ovarian hormones modulate endothelin A and B receptor expression.
New
Pollock et al., Birmingham, United States. In Life Sci, Feb 2016
AIMS: The study aims to determine the modulatory roles of ovarian hormones, estrogen (E2) and progesterone (P), on the expression of endothelin A (ETA) and B (ETB) receptors in lung, liver and kidney tissues.
The therapeutic potential of endothelin receptor antagonism in kidney disease.
Review
New
Dhaun et al., Edinburgh, United Kingdom. In Am J Physiol Regul Integr Comp Physiol, Jan 2016
UNASSIGNED: Our growing understanding of the role of the endothelin (ET) system in renal physiology and pathophysiology is based on the results of emerging studies in humans and animal models of renal disease.
Endothelin-1 and antiangiogenesis.
Review
New
van den Meiracker et al., Bronkhorstspruit, South Africa. In Am J Physiol Regul Integr Comp Physiol, Nov 2015
Studies in eNOS-deficient mice and pharmacological treatment with endothelin receptor blockers and sildenafil indicate that an activated endothelin system, rather than NO suppression mediates the side effects of angiogenesis inhibitors.
[Approaches to therapy for pulmonary hypertension: Role of the endothelin receptor antagonist bosentan].
Review
Avdeev, In Ter Arkh, 2014
Pulmonary hypertension (PH) is a specific clinical group of severe and rare diseases with similar morphological, hemodynamic, and therapeutic characteristics.
Docetaxel and atrasentan versus docetaxel and placebo for men with advanced castration-resistant prostate cancer (SWOG S0421): a randomised phase 3 trial.
Impact
Thompson et al., Los Angeles, United States. In Lancet Oncol, 2013
Atrasentan, an endothelin receptor antagonist, has shown activity in prostate cancer.
Endothelin-3 expression in the subfornical organ enhances the sensitivity of Na(x), the brain sodium-level sensor, to suppress salt intake.
Impact
Noda et al., Okazaki, Japan. In Cell Metab, 2013
Pharmacological experiments revealed that endothelin receptor B (ET(B)R) signaling is involved in this modulation of Na(x) gating through protein kinase C and ERK1/2 activation.
NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche.
Impact
Fuchs et al., New York City, United States. In Nature, 2013
Conversely, endothelin receptor antagonists and/or KIT blocking antibodies prevent precocious melanocyte stem cell differentiation in the NFIB-deficient niche.
Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis.
GeneRIF
Beier et al., London, Canada. In J Orthop Res, 2012
expression in articular cartilage is increased in response to both surgical induction of osteoarthritis and TGFalpha treatment
The pharmacological treatment of pulmonary arterial hypertension.
Review
Impact
Frumkin, In Pharmacol Rev, 2012
Advances in understanding the pathobiology over the last 2 decades have led to therapies (endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, and prostacyclins or analogs) initially directed at reversing the pulmonary vasoconstriction and more recently directed toward reversing endothelial cell dysfunction and smooth muscle cell proliferation.
Assessment of endothelin-A receptor expression in subcutaneous and orthotopic thyroid carcinoma xenografts in vivo employing optical imaging methods.
GeneRIF
Höltke et al., Münster, Germany. In Endocrinology, 2012
Data show that optical imaging with a fluorescent ET(A)R tracer allows the noninvasive imaging of tumor-associated ET(A)R expression in vivo.
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA.
GeneRIF
Nakamura et al., Tokyo, Japan. In Hum Mol Genet, 2012
SNP, rs6842241, near EDNRA at chromosome 4q31.22 (combined P-value = 9.58 x 10(-9); odds ratio = 1.25), was found to be significantly associated with intracranial aneurysm
EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ.
GeneRIF
Rapoport et al., Cincinnati, United States. In Naunyn Schmiedebergs Arch Pharmacol, 2012
ET(A)-ET(B) receptor cross-talk is present in the rat basilar artery
Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction.
GeneRIF
Ren et al., Xi'an, China. In J Mol Cell Biol, 2012
Knockout of ET(A) receptor protects against cold temperature-induced cardiac hypertrophy and contractile dysfunction.
Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2).
Impact
Kassell et al., Toronto, Canada. In Lancet Neurol, 2011
BACKGROUND: Clazosentan, an endothelin receptor antagonist, significantly and dose-dependently reduced angiographic vasospasm after aneurysmal subarachnoid haemorrhage (aSAH).
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