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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Meprin A, alpha

endopeptidase-2, MEP1B, MEP1A, PPH alpha
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, Insulin, SET
Papers on endopeptidase-2
MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.
New
Shi et al., Guangzhou, China. In Hepatology, Jan 2016
We investigated the relationship between MEP1A, a candidate oncogene, and clinical outcomes of HCC patients; furthermore, we explored the role of MEP1A in HCC.
SNP and INDEL detection in a QTL region on chicken chromosome 2 associated with muscle deposition.
New
Coutinho et al., Piracicaba, Brazil. In Anim Genet, Apr 2015
Fifteen non-tolerated SNPs were detected in several genes (MEP1B, PRKDC, NSMAF, TRAPPC8, SDR16C5, CHD7, ST18 and RB1CC1).
endoProteoFASP: a novel FASP approach to profile salivary peptidome and disclose salivary proteases.
Vitorino et al., Aveiro, Portugal. In Talanta, 2015
Peptide fragments were mainly attributed to the activity of cathepsin L1 and K at 18 h, whereas at 115 h, the attained peptide fragments were attributed to the activity of cathepsins K and L1, and MEP1A.
Origin and Diversification of Meprin Proteases.
Marín, Valencia, Spain. In Plos One, 2014
While many vertebrates have the two canonical meprin-encoding genes orthologous to human MEP1A and MEP1B (which respectively encode for the proteins known as meprin α and meprin β), a single gene has been found so far in the genome of the chondrichthyan fish Callorhinchus milii, and additional meprin-encoding genes are present in some species.
Hyperoxia-Induced Protein Alterations in Renal Rat Tissue: A Quantitative Proteomic Approach to Identify Hyperoxia-Induced Effects in Cellular Signaling Pathways.
Braunecker et al., Köln, Germany. In Dis Markers, 2014
MEP1A and VDAC1 could be promising candidates to identify hyperoxic injury in kidney cells.
A genetic screen in Drosophila for regulators of human prostate cancer progression.
Miki et al., Kyoto, Japan. In Biochem Biophys Res Commun, 2014
The human homologues of these candidate genes - MRGBP, CNPY2, and MEP1A - were found to be expressed in human prostate cancer model cells and to promote replication and invasiveness in these cells.
Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome.
Obermayer-Pietsch et al., Graz, Austria. In Gene, 2014
We aimed to investigate the association of genetic variants 3'UTR rs17468190 (G/T) of the inflammation-associated gene MEP1A (GenBank ID: NM_005588.2) with metabolic disturbances in PCOS and healthy control women.
The role of CDX2 in inflammatory bowel disease.
Review
Coskun, Denmark. In Dan Med J, 2014
The role of CDX2 in the transcriptional regulation of MEP1A and the β-catenin degradation complex genes APC, AXIN2, and GSK3β were investigated in Caco-2 cells.
Overexpression of membrane proteins in primary and metastatic gastrointestinal neuroendocrine tumors.
Howe et al., Iowa City, United States. In Ann Surg Oncol, 2013
Significant overexpression was observed for MUC13 and MEP1B in PNET primary tumors, and for GPR113 in primary SBNETs and their metastases.
Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength.
Becker-Pauly et al., Kiel, Germany. In Proc Natl Acad Sci U S A, 2013
We report that Mep1a(-/-) and Mep1b(-/-) mice revealed lower amounts of mature collagen I compared with WT mice and exhibited significantly reduced collagen deposition in skin, along with markedly decreased tissue tensile strength.
Appearance, flavor, and texture attributes of pig dry-cured hams have a complex polygenic genomic architecture.
Quintanilla et al., Lleida, Spain. In J Anim Sci, 2013
Several functional candidate genes involved in the biochemical processes that shape flavor and texture attributes, such as ANPEP, LIPE, LIPA, MEP1B, and MMP28, co-localized with QTL hotspots.
Post-transcriptional regulation of meprin α by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP).
Ishmael et al., United States. In J Biol Chem, 2013
The enhanced binding of tristetraprolin to the MEP1A 3'-UTR results in destabilization of the transcript and occurs at a discrete site from Hu antigen R.
Effects of low progesterone on the endometrial transcriptome in cattle.
Lonergan et al., Dublin, Ireland. In Biol Reprod, 2012
Analysis of selected genes by quantitative real-time PCR and in situ hybridization revealed that expression of MEP1B, NID2, and PRSS23 increased on Day 13 compared to Day 7 (P < 0.05) and that the magnitude of increase was significantly diminished in heifers with low P4 compared to controls.
TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis.
GeneRIF
Troelsen et al., Copenhagen, Denmark. In Biochim Biophys Acta, 2012
The present results indicate that a TNF-alpha-mediated down-regulation of CDX2 can be related to suppressed expression of MEP1A during intestinal inflammation.
Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney.
GeneRIF
Kawasaki et al., Kyoto, Japan. In Glycobiology, 2012
the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.
GeneRIF
Becker-Pauly et al., Mainz, Germany. In J Biol Chem, 2011
Processing of APP by meprin beta was subsequently validated using in vitro and in vivo approaches. N-terminal APP fragments of about 11 and 20 kDa were found in human and mouse brain lysates but not in meprin beta(-/-) mouse brain lysates
Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.
GeneRIF
Bond et al., United States. In Am J Physiol Gastrointest Liver Physiol, 2011
Absence of meprin A aggravates chronic inflammation and lack of meprin B affords some protection from injury. Manipulation of expression of meprin gene products may have therapeutic potential.
Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer.
GeneRIF
Sterchi et al., Bern, Switzerland. In Plos One, 2010
Meprin-alpha activity is regulated differently in primary tumors and metastases of colorectal cancer. By virtue of its pro-migratory and pro-angiogenic activity, meprin-alpha may promote tumor progression in colorectal cancer.
Transcriptome studies of bovine endometrium reveal molecular profiles characteristic for specific stages of estrous cycle and early pregnancy.
Review
Wolf et al., München, Germany. In Exp Clin Endocrinol Diabetes, 2008
Transcriptome studies of endometrial samples recovered during the pre-attachment period identified many interferon-stimulated genes, genes that are possibly involved in embryo-maternal immune modulation ( C1S, C1R, C4, SERPING1, UTMP, CD81, IFITM1, BST2), as well as genes affecting cell adhesion ( AGRN, CD81, LGALS3BP, LGALS9, GPLD1, MFGE8, and TGM2) and remodeling of the endometrium ( CLDN4, MEP1B, LGMN, MMP19, TIMP2, TGM2, MET, and EPSTI1).
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