Effect of Superoxide Anion Scavenger on Rat Hearts with Chronic Intermittent Hypoxia.
China. In J Appl Physiol, Feb 2016
Superoxide anion scavenger decreased HYPOXIA-induced Fas ligand, Fas death receptors, Fas-associated death domain (FADD), activated caspase-8, and activated caspase-3 (Fas-dependent apoptotic pathway) as well as Bad, activated caspase-9 and activated caspase-3 (mitochondria-dependent apoptotic pathway), endonuclease G (EndoG), apoptosis-inducing factor (AIF) and TUNEL-positive apoptosis.
The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells.
Washington, D.C., United States. In Aging (albany Ny), Oct 2015
The inhibition of p53 in the presence of VMY revealed increased late stage apoptosis, increased DNA fragmentation and increased expression of genes involved in apoptosis, including CAPN12 and TRPM8, p63, p73, BIK, EndoG, CIDEB, P27Kip1 and P21cip1.
The role of excitotoxic programmed necrosis in acute brain injury.
Los Angeles, United States. In Comput Struct Biotechnol J, 2014
Calpain I activation produces mitochondrial release of cytochrome c (cyt c), truncated apoptosis-inducing factor (tAIF) and endonuclease G (endoG), the lysosomal release of cathepsins B and D and DNase II, and inactivation of the plasma membrane Na(+)-Ca(2 +) exchanger, which add to the buildup of intracellular Ca(2 +).
Central roles of apoptotic proteins in mitochondrial function.
Dublin, Ireland. In Oncogene, 2013
Cell stress stimuli can result in outer membrane permeabilization, after which mitochondria release numerous proteins involved in apoptotic signaling, including cytochrome c, apoptosis-inducing factor, endonuclease G, Smac/DIABLO and Omi/HtrA2.