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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


endoglin, CD105
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: Thy-1, CAN, CD34, 5'-nucleotidase, CD45
Papers using endoglin antibodies
Induction of pancreatic beta-cell-like cells from CD44+/CD105+ human amniotic fluids via epigenetic regulation of the pancreatic and duodenal homeobox factor 1 promoter
Zou Gang et al., In International Journal of Medical Sciences, 2009
... human amniotic fluid using 4μl of the primary monoclonal antibodies (mouse anti-human CD44-FITC, rabbit anti-human CD105-PE, eBioscience Inc, San Diego, CA, ...
Contractile smooth muscle cells derived from hair-follicle stem cells.
Emanueli Costanza, In PLoS ONE, 2007
... CD44 antibody was from antibodies online (Aachen, Germany), CD90 antibody from ebioscience (San Diego, USA), CD105 and TAGLN antibodies from Acris Antibodies (Herford, Germany), CD105, ...
Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow
Lesniak Maciej S., In PLoS ONE, 1996
... phycoerytrin (PE) (BD Biosciences Pharmingen), CD90 PE (BD Biosciences Pharmingen), CD73 PE (BD Biosciences Pharmingen), CD105 FITC (Diaclone, Besancon, France), CD44 FITC ...
Expression of the leukocyte common antigen CD45 by endothelium
Goodell Margaret A., In PLoS Biology, 1992
... The antibodies used included APC anti-mouse CD31 (BD Pharmingen) and PE anti-mouse CD105 (eBioscience), V450 Sca-1 (BD Biosciences), ...
Papers on endoglin
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
Girkontaitė et al., Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
RESULTS: Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls.
Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation.
Gurgel Rocha et al., Salvador, Brazil. In Tumour Biol, Feb 2016
Twenty-eight cases of OSCC, nine cases of tumor-free resection margins (TM), and four cases of non-neoplastic oral mucosa (NNM) were submitted to immunohistochemistry to detect proteins Sonic Hedgehog (SHH), Indian Hedgehog (IHH), GLI1, CD163, and CD105.
Toll-like Receptor Expression Profile of Human Dental Pulp Stem/Progenitor Cells.
Dörfer et al., Kiel, Germany. In J Endod, Feb 2016
DPSCs were characterized for CD14, CD34, CD45, CD73, CD90, CD105, and CD146 expression and for their multilineage differentiation potential.
Biomarkers in systemic sclerosis: Their potential to predict clinical courses.
Hasegawa, Fukui, Japan. In J Dermatol, Jan 2016
Other potential serum/plasma biomarkers for fibrosis and vascular involvement of SSc are connective tissue growth factor, interleukin-6, CCL2, CXCL4, intercellular adhesion molecule (ICAM)-1, P-selectin, vascular endothelial growth factor, von Willebrand factor, endostatin, endoglin and endothelin-1.
Dynamics of circulating microparticles in chronic kidney disease and transplantation: Is it really reliable marker?
Unsur et al., Kayseri, Turkey. In World J Transplant, Jan 2016
EMPs having CD144, CD 146, CD31(+)/CD41(-), CD51 and CD105 may be used to evaluate the vascular endothelial cell damage and determine asymptomatic patients who might be at higher risk of developing cardiovascular disease in CKD and renal transplant.
Soluble endoglin, hypercholesterolemia and endothelial dysfunction.
Nachtigal et al., Hradec Králové, Czech Republic. In Atherosclerosis, Dec 2015
A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length membrane endoglin, which is elevated during various pathological conditions related to vascular endothelium.
Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects.
Grünig et al., Lincoln, United Kingdom. In Hum Mutat, Dec 2015
Specifically, studies have confirmed activin A receptor type II-like 1 (ACVRL1), endoglin (ENG), and members of the SMAD family as contributing to PAH both with and without associated clinical phenotypes.
Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis.
Wojciak-Stothard et al., Madrid, Spain. In J Biomed Sci, Dec 2015
BACKGROUND: Increased circulating levels of endoglin(+) endothelial microparticles (EMPs) have been identified in several cardiovascular disorders, related to severity.
Role of Endoglin Insertion and rs1800956 Polymorphisms in Intracranial Aneurysm Susceptibility: A Meta-Analysis.
You et al., Chengdu, China. In Medicine (baltimore), Nov 2015
Endoglin is an essential molecule during angiogenesis, vascular development, and integrity.
Research Note Mesenchymal stem cells from skin lesions of psoriasis patients promote proliferation and inhibit apoptosis of HaCaT cells.
Zhang et al., Taiyuan, China. In Genet Mol Res, 2014
Cell morphologies and multipotencies of skin MSCs were similar between the psoriasis group and healthy control group, with high levels of CD29, CD44, CD73, CD90, and CD105 and limited expression of CD34, CD45, and HLA-DR.
Phase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report.
Blaney et al., New York City, United States. In J Clin Oncol, 2013
Placental growth factor increased, whereas endoglin and soluble vascular endothelial growth factor receptor-2 decreased (P < .01;
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.
Greenwood et al., London, United Kingdom. In Nature, 2013
LRG1 binds directly to the TGF-β accessory receptor endoglin, which, in the presence of TGF-β1, results in promotion of the pro-angiogenic Smad1/5/8 signalling pathway.
Effect of endoglin overexpression during embryoid body development.
Perlingeiro et al., Minneapolis, United States. In Exp Hematol, 2012
Eng modulates the hematopoietic transcriptional network, most likely through regulation of BMP4 signaling.
Chronic cerebral hypoxia promotes arteriogenic remodeling events that can be identified by reduced endoglin (CD105) expression and a switch in β1 integrins.
Milner et al., Los Angeles, United States. In J Cereb Blood Flow Metab, 2012
our data suggest a mechanistic model whereby brain endothelial cells in remodeling arterial vessels downregulate CD105 expression, which alters TGF-beta1 signaling, to promote a switch in beta1 integrins and arteriogenic remodeling
Endoglin inhibits ERK-induced c-Myc and cyclin D1 expression to impede endothelial cell proliferation.
Lee et al., Columbus, United States. In Biochem Biophys Res Commun, 2012
endoglin impedes endothelial cell growth through sustained inhibition of ERK-induced c-Myc and cyclin D1 expression in a TGF-beta-independent manner.
Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis.
Blobe et al., Durham, United States. In Mol Biol Cell, 2012
a novel non-Smad function for endoglin and GIPC in regulating endothelial cell function during angiogenesis
A critical role for endoglin in the emergence of blood during embryonic development.
Perlingeiro et al., Minneapolis, United States. In Blood, 2012
Endoglin (Eng), a receptor for the TGF-beta superfamily, identifies all cells with hematopoietic fate in the early embryo.
Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors.
Buchholz et al., Langen, Germany. In Nat Methods, 2010
We generated lentiviral vectors specific for human CD105(+) endothelial cells, human CD133(+) hematopoietic progenitors and mouse GluA-expressing neurons.
Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation.
Hauck et al., Konstanz, Germany. In Science, 2010
CEA binding triggered de novo expression of the transforming growth factor receptor CD105, changing focal adhesion composition and activating beta1 integrins.
Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia.
Mummery et al., Paris, France. In Nat Med, 2010
In mice heterozygous for a null mutation in the Eng gene (encoding endoglin), an experimental model of HHT, thalidomide treatment stimulated mural cell coverage and thus rescued vessel wall defects.
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