Endo180 at the cutting edge of bone cancer treatment and beyond.
Kingston upon Hull, United Kingdom. In J Pathol, Dec 2015
For the first time they have demonstrated that a mouse monoclonal antibody targeting the collagen receptor Endo180 (CD280, MRC2, uPARAP) can prevent osteolysis and bone destruction in a syngeneic model of advanced osteosarcoma.
Mannose receptor 2 attenuates renal fibrosis.
Seattle, United States. In J Am Soc Nephrol, 2012
data establish an important fibrosis-attenuating role for Mrc2-expressing renal interstitial cells and suggest the involvement of a lysosomal collagen turnover pathway
The collagen receptor uPARAP/Endo180.
Copenhagen, Denmark. In Front Biosci, 2008
The uPAR-associated protein (uPARAP/Endo180), a type-1 membrane protein belonging to the mannose receptor family, is an endocytic receptor for collagen.