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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ectodermal-neural cortex 1

ENC1, Ectodermal Neural Cortex 1
This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: ACID, SNAIL, Actin, OUT, fibrillin-1
Papers on ENC1
Transcriptome profiling of human FoxP3(+) regulatory T cells.
New
Shevach et al., Bethesda, United States. In Hum Immunol, Jan 2016
Notably, a number of yet uncharacterized genes (RTKN2, LAYN, UTS2, CSF2RB, TRIB1, F5, CECAM4, CD70, ENC1 and NKG7) were identified and validated as being differentially expressed in human Tregs.
A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue.
New
Aberg et al., Richmond, United States. In Schizophr Bull, Jan 2016
Our top result in the brain MWAS (P-value = 8.8×10(-7)) was CpG-SNP rs16872141 located in the potential promoter of ENC1.
ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress.
New
Jung et al., Seoul, South Korea. In Mol Neurobiol, Jan 2016
Here, we show that ectodermal-neural cortex 1 (ENC1), a novel binding partner of sequestosome 1 (p62), negatively regulates autophagy under endoplasmic reticulum (ER) stress.
Molecular phylogeny and evolution of internal fertilization in South American seasonal cynopoeciline killifishes.
New
Mattos et al., Rio de Janeiro, Brazil. In Mol Phylogenet Evol, Dec 2015
We analyzed three nuclear loci (GLYT1, ENC1, Rho) for 13 aplocheiloid taxa obtaining the first well-supported phylogeny for cynopoecilines, thus providing a significant background to interpret evolutionary changes within the group.
Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis.
Flück et al., Bern, Switzerland. In Sci Rep, 2014
Microarray expression profiling of normal versus starved H295R cells revealed fourteen differentially expressed genes; HSD3B2, HSD3B1, CYP21A2, RARB, ASS1, CFI, ASCL1 and ENC1 play a role in steroid and energy metabolism and ANGPTL1, PLK2, DUSP6, DUSP10 and FREM2 are involved in signal transduction.
Identification of a subtype-specific ENC1 gene related to invasiveness in human pituitary null cell adenoma and oncocytomas.
Zhang et al., Beijing, China. In J Neurooncol, 2014
Secondly, the expression of ENC1, which displayed the significant alterations, was further confirmed by qRT-PCR and Western blot analysis in all 43 tumor samples and three normal pituitary glands.
Comprehensive study of tumour single nucleotide polymorphism array data reveals significant driver aberrations and disrupted signalling pathways in human hepatocellular cancer.
Li et al., Hefei, China. In Iet Syst Biol, 2014
By applying the approach to 286 hepatocellular tumour samples, they successfully uncover numerous driver aberration regions across the cancer genome, for example, chromosomes 4p and 5q, which harbour many known hepatocellular cancer related genes such as alpha-fetoprotein (AFP) and ectodermal-neural cortex (ENC1).
A multilocus molecular phylogeny of combtooth blennies (Percomorpha: Blennioidei: Blenniidae): multiple invasions of intertidal habitats.
Simons et al., Saint Paul, United States. In Mol Phylogenet Evol, 2014
Herein, we use Bayesian and maximum likelihood analyses of four nuclear loci (ENC1, myh6, ptr, and tbr1) from 102 species, representing 41 genera, to resolve the phylogeny of the Blenniidae, determine the validity of the previously recognized groupings, and explore the evolution of habitat association using ancestral state reconstruction.
Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling.
Qin et al., New York City, United States. In J Spinal Cord Med, 2013
SCI reduced mRNA levels of Wnt signaling-related genes Wnt3a, low-density lipoprotein receptor-related protein 5 (LRP5), Fzd5, Tcf7, and ectodermal-neural cortex 1 (ENC1) in osteoblasts, whereas nandrolone increased expression of each of these genes.
ENC1-like integrates the retinoic acid/FGF signaling pathways to modulate ciliogenesis of Kupffer's Vesicle during zebrafish embryonic development.
Mo et al., Chengdu, China. In Dev Biol, 2013
The left-right asymmetry is an essential feature shared by vertebrates.
Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin.
Kuraku et al., Konstanz, Germany. In Genome Biol Evol, 2012
Our analysis revealed that the ENC3 ortholog was lost in the basal eutherian lineage through single-gene deletion and that the triplication between ENC1, -2, and -3 occurred early in vertebrate evolution.
Gene trees, species trees, and morphology converge on a similar phylogeny of living gars (Actinopterygii: Holostei: Lepisosteidae), an ancient clade of ray-finned fishes.
Near et al., Ann Arbor, United States. In Mol Phylogenet Evol, 2012
Here, we present the first hypothesis of phylogenetic relationships among living gar species based on molecular data, through the examination of gene tree heterogeneity and coalescent species tree analyses of a portion of one mitochondrial (COI) and seven nuclear (ENC1, myh6, plagl2, S7 ribosomal protein intron 1, sreb2, tbr1, and zic1) genes.
Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses.
Howley et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Binding of E7 to UBR4/p600 is conserved across all virus types, whereas the cellular protein ENC1 binds specifically to the E7s from HPV18 and HPV45, both members of genus alpha, species 7. We identify a specific interaction of HPV16 E7 with ZER1, a substrate specificity factor for a cullin 2 (CUL2)-RING ubiquitin ligase, and show that ZER1 is required for the binding of HPV16 E7 to CUL2.
Overexpression of Nrp/b (nuclear restrict protein in brain) suppresses the malignant phenotype in the C6/ST1 glioma cell line.
GeneRIF
Sogayar et al., São Paulo, Brazil. In J Steroid Biochem Mol Biol, 2009
show that overexpression of the Nrp/b cDNA in C6/ST1 cells suppresses anchorage independence in vitro and tumorigenicity in vivo, altering their malignant nature towards a more benign phenotype.
Expression of ectodermal neural cortex 1 and its association with actin during the ovulatory process in the rat.
GeneRIF
Chun et al., Kwangju, South Korea. In Endocrinology, 2009
The study further shows the physical association of ENC1 and F-actin, implicating the role of ENC1 in cytoskeletal reorganization during the differentiation of granulosa cells.
NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors.
GeneRIF
Avraham et al., Boston, United States. In Oncogene, 2009
NRP/B mutations impair Nrf2-dependent NQO1 induction in primary brain tumors.
Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.
GeneRIF
Zhang et al., United States. In Plos One, 2008
ENC1 functions as a negative regulator of Nrf2 through suppressing Nrf2 protein translation.
Integrative biology of an embryonic respiratory behaviour in pond snails: the 'embryo stir-bar hypothesis'.
Review
Kuang et al., Calgary, Canada. In J Exp Biol, 2008
The discovery of a bilateral pair of early serotonergic neurons, named ENC1, which project an apical process to the embryo surface and basal neurites to ciliated cells, prompted the hypothesis that each ENC1 is a dual-function sensory and motor neuron mediating a physiological embryonic response.
The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells.
GeneRIF
Avraham et al., Boston, United States. In Cancer Res, 2007
NRP/B enhances oxidative stress responses in breast cancer cells via the Nrf2 pathway, identifying a novel role of nuclear matrix protein(s) in oxidative stress responses.
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