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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Sodium channel, nonvoltage-gated 1, delta

ENaCdelta, delta-ENaC, hENaCdelta, SCNED, SCNN1D
Top mentioned proteins: ENaC, ACID, CAN, beta-ENaC, ASIC1a
Papers on ENaCdelta
Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.
Review
New
Hanukoglu et al., Jerusalem, Israel. In Gene, Feb 2016
The subunits that form ENaC (named as alpha, beta, gamma and delta, encoded by genes SCNN1A, SCNN1B, SCNN1G, and SCNN1D) are members of the ENaC/Degenerin superfamily.
δ ENaC: a novel divergent amiloride-inhibitable sodium channel.
Review
Matalon et al., Tyler, United States. In Am J Physiol Lung Cell Mol Physiol, 2013
The altered expression of SCNN1D is associated with numerous pathological conditions.
Genetic analysis of chemosensory traits in human twins.
Reed et al., Philadelphia, United States. In Chem Senses, 2012
The flavor of ethanol was related to variation within an olfactory receptor gene (OR7D4) and a gene encoding a subunit of the epithelial sodium channel (SCNN1D).
Characterization of a novel splice variant of δ ENaC subunit in human lungs.
GeneRIF
Ji et al., Tyler, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
study characterized a new variant, delta2 ENaC, in lung epithelial cells; heterologous delta2betagamma ENaC exhibited a number of divergent features from the delta1betagamma counterpart in biophysics and pharmacology, regulation, and the lifespan of proteins
Permeability of the arachnoid and pia mater. The role of ion channels in the leptomeningeal physiology.
Hatzoglou et al., Lárisa, Greece. In Childs Nerv Syst, 2012
Immunohistochemical studies of leptomeningeal tissue were prepared with alpha-1 sodium-potassium-ATPase (ATP1A1), beta-ENaC, and delta-ENaC subunit antibodies.
Differential N termini in epithelial Na+ channel δ-subunit isoforms modulate channel trafficking to the membrane.
GeneRIF
Giraldez et al., Candelaria, Spain. In Am J Physiol Cell Physiol, 2012
delta-ENaC undergoes dynamin-independent endocytosis as opposed to alphabetagamma-channels.
8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channels.
GeneRIF
Ji et al., Tyler, United States. In Am J Respir Cell Mol Biol, 2011
CPT-cGMP Stimulates Human Alveolar Fluid Clearance by Releasing External Na+ Self-Inhibition of ENaC.
COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination.
GeneRIF
McDonald et al., Dunedin, New Zealand. In Biochem Biophys Res Commun, 2011
These results suggest that COMMD1 downregulates deltaENaC activity by reducing deltaENaC surface expression through promoting internalization of surface deltaENaC to an intracellular recycling pool, possibly via enhanced ubiquitination.
Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition.
GeneRIF
Ji et al., Tyler, United States. In Biochim Biophys Acta, 2011
Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition.
Characterization of the epithelial sodium channel delta-subunit in human nasal epithelium.
Weber et al., Münster, Germany. In Am J Respir Cell Mol Biol, 2010
When co-expressed with beta and gamma accessory subunits in heterologous systems, the two known isoforms of the delta-ENaC subunit (delta1 and delta2) can build amiloride-sensitive Na+ channels.
Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles.
Bewick et al., Aberdeen, United Kingdom. In J Physiol, 2010
Moreover, firing was slightly but significantly increased by ENaC delta subunit agonists (icilin and capsazepine).
Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration.
Benos et al., Birmingham, United States. In J Biol Chem, 2009
To test this hypothesis we made dominant negative cDNAs for ASIC1, alphaENaC, gammaENaC, and deltaENaC.
Blockade of epithelial sodium channels improves sperm motility in asthenospermia patients.
GeneRIF
Xiong et al., Wuhan, China. In Int J Androl, 2009
EIPA [5-(N-ethyl-N-isopropyl)-amiloride hydrochloride] inhibition of ENaCs, possibly ENaC-alpha and ENaC-delta, significantly improved the sperm motility in healthy donors and in asthenospermia patients.
[CENTB5 gene expression in human and mouse].
Patkin et al., In Mol Biol (mosk), 2009
Besides this, both human and mice CENTB5 are localized in the same synteny group with SCNN1D and ACOT7 genes which are known to be expressed predominantly in nervous system.
Epithelial Na+ channel delta subunit is an acid sensor in the human oesophagus.
GeneRIF
Shimada et al., Nagoya, Japan. In Eur J Pharmacol, 2009
ENaCdelta is a candidate molecule for pH sensing in the gastrointestinal system in humans, providing a novel therapeutic target for gastro-oesophageal reflux disease
Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue.
Brand et al., Philadelphia, United States. In Plos One, 2008
Immunohistochemistry of fungiform papillae from sour-normal subjects revealed labeling of taste bud cells by antibodies to ASICs 1a and 1beta, PKD2L1, phospholipase C-beta2, and delta-ENaC.
Epithelial Na+ channel delta subunit mediates acid-induced ATP release in the human skin.
Shimada et al., Nagoya, Japan. In Biochem Biophys Res Commun, 2008
Although we described that ENaCdelta is a candidate molecule for a pH sensor in the human brain, the physiological and pathological roles of ENaCdelta in non-neuronal tissues are still unknown.
Expression analysis of the epithelial Na+ channel delta subunit in human melanoma G-361 cells.
GeneRIF
Shimada et al., Nagoya, Japan. In Biochem Biophys Res Commun, 2008
Expression analyses at the level of mRNA clearly revealed that ENaC delta transcript was strongly expressed in human melanoma cells using reverse transcription-polymerase chain reaction and cell-based in situ hybridization techniques.
Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon.
GeneRIF
Alvarez de la Rosa et al., Santa Cruz de Tenerife, Spain. In J Neurochem, 2007
ENaC delta isoforms are widely expressed in pyramidal cells of the human and monkey cerebral cortex and in different neuronal populations of telencephalic subcortical nuclei.
Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction.
GeneRIF
Benos et al., Birmingham, United States. In J Biol Chem, 2006
the interactions of delta-ENaC with alpha beta gamma-human epithelial sodium channel subunits could account for heterogeneity of native epithelial channels
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