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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sodium channel, nonvoltage-gated 1, gamma

ENaC, gamma-ENaC, alpha-ENaC
acts as an epithelial sodium ion channel; regulates salt and fluid transport in the kidney [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, CAN, HAD, ACID, ATPase
Papers using ENaC antibodies
The mouse as a model for human biology: a resource guide for complex trait analysis
Supplier
Vij Neeraj, In PLoS ONE, 2006
... ) were intercrossed with βENaC-Tg mice on the C57BL/6 background and double-transgenic βENaC-Tg/CF mice, single-transgenic βENaC-Tg ...
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Supplier
Sands Jeff M., In PLoS ONE, 2005
... used included anti-actin (Sigma), anti-SGK (serum and glucocorticoid-induced kinase) (Cell Signaling Technology, Beverly, MA) and anti-ENaC antibodies (StressMarq, Vicroria, BC, Canada) ...
Role of SGK in hormonal regulation of epithelial sodium channel in A6 cells
Supplier
Wang Dao-Xin et al., In Respiratory Research, 2002
... Rabbit anti- α-ENaC,β-ENaC and γ-ENaC antibodies were purchased from Santa Cruz Biotechnology(Santa Cruz, CA, USA) Rabbit ...
Papers on ENaC
(Pro)renin receptor contributes to regulation of renal epithelial sodium channel.
New
Siragy et al., Charlottesville, United States. In J Hypertens, Feb 2016
We hypothesized that PRR plays a role in regulation of renal epithelial sodium channel (ENaC) through serum and glucocorticoid-inducible kinase isoform 1 (SGK-1)-neural precursor cell expressed, developmentally downregulated 4-2 (Nedd4-2) signaling pathway.
Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.
New
Hummler et al., Lausanne, Switzerland. In Pflugers Arch, Feb 2016
Germline loss-of-function mutations of the mineralocorticoid receptor (MR) in humans and in mice lead to the "renal" form of type 1 pseudohypoaldosteronism (PHA-1), a case of aldosterone resistance characterized by salt wasting, dehydration, failure to thrive, hyperkalemia, and metabolic acidosis.
Liddle-Mutation of the β-Subunit, but not the γ-Subunit, Attenuates Protein Kinase C-Mediated Inhibition of Human Epithelial Sodium Channels (hENaC).
New
Sandle et al., Leeds, United Kingdom. In J Membr Biol, Feb 2016
UNASSIGNED: Mammalian distal nephron and distal colon, prime sites for Na(+) homeostasis, contain amiloride-sensitive epithelial sodium channels (ENaC).
Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.
Review
New
Hanukoglu et al., Jerusalem, Israel. In Gene, Feb 2016
The subunits that form ENaC (named as alpha, beta, gamma and delta, encoded by genes SCNN1A, SCNN1B, SCNN1G, and SCNN1D) are members of the ENaC/Degenerin superfamily.
Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets.
Review
New
Brodlie et al., Newcastle upon Tyne, United Kingdom. In Thorax, Jan 2016
These include the epithelial sodium channel (ENaC), the solute carrier 26A (SLC26A) family of anion exchangers, and calcium-activated chloride channels.
Urinary extracellular vesicles as markers to assess kidney sodium transport.
New
Hoorn et al., Århus, Denmark. In Curr Opin Nephrol Hypertens, Jan 2016
The effects of aldosterone on kidney sodium transport, including activation of the sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC), are transferred to uEVs as increases in phosphorylated NCC and the γ-subunit of ENaC.
Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport.
New
Ellison et al., Portland, United States. In J Am Soc Nephrol, Jan 2016
Aldosterone activates mineralocorticoid receptors (MRs) to increase epithelial sodium channel (ENaC) activity.
Role of epithelial sodium channels in the regulation of lung fluid homeostasis.
Review
New
Collawn et al., Gdańsk, Poland. In Am J Physiol Lung Cell Mol Physiol, Jan 2016
Any factor that interferes with Na(+) or Cl(-) transport or dramatically upregulates ENaC activity in airway epithelial cells has been associated with lung diseases such as cystic fibrosis or chronic obstructive lung disease.
The Role of Pendrin in Blood Pressure Regulation.
Review
New
Wall, In Am J Physiol Renal Physiol, Dec 2015
Pendrin mediates Cl(-) absorption and modulates aldosterone-induced Na(+) absorption mediated by ENaC.
Renal autoregulation in health and disease.
Review
New
Impact
Arendshorst et al., Colombia. In Physiol Rev, Apr 2015
Proposed mechanosensors include epithelial sodium channels (ENaC), integrins, and/or transient receptor potential (TRP) channels.
Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited.
Review
Impact
Studer et al., Lausanne, Switzerland. In Physiol Rev, 2015
The action of aldosterone on transepithelial sodium transport by activation of the epithelial sodium channel (ENaC) at the apical membrane and that of Na(+)-K(+)-ATPase at the basolateral membrane may have evolved in lungfish before the emergence of tetrapods.
International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel.
Review
Impact
Schild et al., Lausanne, Switzerland. In Pharmacol Rev, 2014
The epithelial Na(+) channel (ENaC) and the acid-sensing ion channels (ASICs) form subfamilies within the ENaC/degenerin family of Na(+) channels.
Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport.
Review
Horita et al., Tokyo, Japan. In Biomed Res Int, 2014
Likewise, in distal convoluted tubules and cortical collecting ducts, insulin-induced Akt phosphorylation mediates several hormonal signals to enhance sodium-chloride cotransporter (NCC) and epithelial sodium channel (ENaC) activities, resulting in increased sodium reabsorption.
High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets.
Impact
Amaral et al., Lisbon, Portugal. In Cell, 2013
Dysfunction of ENaC, the epithelial sodium channel that regulates salt and water reabsorption in epithelia, causes several human diseases, including cystic fibrosis (CF).
High salt recruits aversive taste pathways.
Impact
Zuker et al., New York City, United States. In Nature, 2013
We have shown previously that the appetitive responses to NaCl are mediated by taste receptor cells expressing the epithelial sodium channel, ENaC, but the cellular substrate for salt aversion was unknown.
Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity.
GeneRIF
Rubenstein et al., Pittsburgh, United States. In Am J Physiol Renal Physiol, 2012
Multiple residues in the distal C terminus of the alpha-subunit have roles in modulating human epithelial sodium channel activity.
Activation of the epithelial Na+ channel triggers prostaglandin E₂ release and production required for embryo implantation.
Impact
GeneRIF
Chan et al., Hong Kong, Hong Kong. In Nat Med, 2012
These results indicate a previously undefined role of ENaC in regulating the PGE production and release required for embryo implantation.
Aldosterone-independent regulation of the epithelial Na+ channel (ENaC) by vasopressin in adrenalectomized mice.
GeneRIF
Stockand et al., San Antonio, United States. In Proc Natl Acad Sci U S A, 2012
Aldosterone-independent stimulation by AVP shifts the role of ENaC in the ASDN from protecting Na(+) balance to promoting water reabsorption
An inhibitory peptide derived from the α-subunit of the epithelial sodium channel (ENaC) shows a helical conformation.
GeneRIF
Korbmacher et al., Erlangen, Germany. In Cell Physiol Biochem, 2011
findings suggest that a helical conformation in its carboxyterminal part is functionally important to mediate ENaC inhibition by the alpha-13-mer peptide
Investigation on genetic heterogeneity of α-subunit of the epithelial sodium channel in rat renal cortex.
GeneRIF
Ivanova et al., Novosibirsk, Russia. In Bull Exp Biol Med, 2011
It was found that mRNA deletion forms (a and b), products of alternative splicing of aENaC gene, are absent in the cortex of adult rat kidney.
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