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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Engrailed 2

en-2, Engrailed-2
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: en-1, ACID, V1a, CAN, CIs
Papers on en-2
Stereoselective synthesis of oxazolidinonyl-fused piperidines of interest as selective muscarinic (M1) receptor agonists: a novel M1 allosteric modulator.
New
Thomas et al., Cardiff, United Kingdom. In Org Biomol Chem, Feb 2016
The hydroboration-oxidation of (4SR,5RS)-3-benzyl-4-(tert-butyldimethylsilyloxymethyl)-4-cyclobutyl-5-(1-methoxyprop-2-en-2-yl)-1,3-oxazolidin-2-one gave (4SR,5RS)-3-benzyl-4-(tert-butyldimethylsilyloxymethyl)-4-cyclobutyl-5-[(SR)-1-hydroxy-3-methoxyprop-2-yl]-1,3-oxazolidin-2-one stereoselectively.
Tricyclohexylphosphine-Catalyzed Cycloaddition of Enynoates with [60]Fullerene and the Application of Cyclopentenofullerenes as n-Type Materials in Organic Photovoltaics.
New
Chuang et al., Yü-ching, Taiwan. In Org Lett, Feb 2016
The tricyclohexylphosphine-catalyzed [3 + 2] cycloaddition of (E)-alkyl 5-substituted phenylpent-4-en-2-ynoates with [60]fullerene was studied.
Selective oxidation of carotenoid-derived aroma compounds by CYP260B1 and CYP267B1 from Sorangium cellulosum So ce56.
New
Bernhardt et al., Saarbrücken, Germany. In Appl Microbiol Biotechnol, Feb 2016
Moreover, CYP260B1 showed an epoxidase activity towards β-ionone [(E)-4-(2,6,6-trimethylcyclohex-1-enyl)but-3-en-2-one] as well as the methyl-substituted α-ionone derivatives raldeine [(E)-1-(2,6,6-trimethylcyclohex-2-enyl)pent-1-en-3-one] and isoraldeine [(E)-3-methyl-4-(2,6,6-trimethylcyclohex-2-enyl)but-3-en-2-one].
Thermodynamic Control of Isomerizations of Bicyclic Radicals: Interplay of Ring Strain and Radical Stabilization.
New
Houk et al., Los Angeles, United States. In Org Lett, Feb 2016
The rearrangements of 4-substituted bicyclo[2.2.2]oct-5-en-2-yl radicals, generated from the corresponding Diels-Alder adducts with phenylseleno acrylates by radical-induced reductive deselenocarbonylations, give the 2-substituted bicyclo[3.2.1]oct-6-en-2-yl radicals with some substituents, e.g., alkoxy and phenyl, but not for silyloxymethyl or benzyl substituents.
Chemoselective Synthesis of 1-Substituted 4-Amino-2-(trifluoromethyl)-1H-pyrroles through the Heterocyclization Reaction of 4-Methoxy-5-bromo-1,1,1-trifluoropent-3-en-2-ones with Amines.
New
Zanatta et al., Santa Maria, Brazil. In J Org Chem, Jan 2016
A concise method to synthesize 1-substituted 4-amino-2-(trifluoromethyl)-1H-pyrroles from the heterocyclization reaction of 5-bromo-4-methoxy-1,1,1-trifluoropent-3-en-2-ones with amines is described.
Hippocampal dysregulation of FMRP/mGluR5 signaling in engrailed-2 knockout mice: a model of autism spectrum disorders.
New
Bozzi et al., Pisa, Italy. In Neuroreport, Jan 2016
Many evidences indicate that mice lacking the homeobox transcription factor engrailed-2 (En2 mice) represent a reliable model to investigate neurodevelopmental basis and gene expression changes relevant to autism spectrum disorders.
Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri.
New
Li et al., Guangzhou, China. In Mar Drugs, Dec 2015
Five novel compounds, including 5-olefin phenylpyropene A (1), 13-dehydroxylpyripyropene A (4), deacetylsesquiterpene (7), 5-formyl-6-hydroxy-8-isopropyl-2- naphthoic acid (9) and 6,8-dihydroxy-3-((1E,3E)-penta-1,3-dien-1-yl)isochroman-1-one (10), together with eleven known compounds, phenylpyropene A (2) and C (3), pyripyropene A (5), 7-deacetylpyripyropene A (6), (1S,2R,4aR,5R,8R,8aR)-1,8a-dihydroxy-2-acetoxy-3,8-dimethyl-5- (prop-1-en-2-yl)-1,2,4a, 5,6,7,8,8a-octahydronaphthalene (8), isochaetominine C (11), trichodermamide A (12), indolyl-3-acetic acid methyl ester (13), 1-acetyl-β-carboline (14), 1,2,3,4-tetrahydro-6-hydroxyl-2-methyl-l,3,4-trioxopyrazino[l,2-a]-indole (15) and fumiquinazoline F (16), were obtained.
Immunohistochemistry Biomarkers in Nonmuscle Invasive Bladder Cancer.
New
Bica et al., Guildford, United Kingdom. In Appl Immunohistochem Mol Morphol, Dec 2015
Biomarkers, including p53, Ki-67, and CK20, with classic and prognostic factors with recurrence and novel markers such as EN2 may provide a more accurate prediction of outcome compared with any single marker, improving risk stratification and clinical management of patients with BCa.
Crystal and mol-ecular structure of aflatrem.
New
Sewald et al., Yaoundé, Cameroon. In Acta Crystallogr E Crystallogr Commun, Dec 2015
The skeleton is completed by the 7,7-trimethyl-6,8-dioxabi-cyclo-[3.2.1]oct-3-en-2-one group connected to the terminal cyclohexene ring.
EN2 in Prostate Cancer.
Review
Pandha et al., Guildford, United Kingdom. In Adv Clin Chem, 2014
EN2 is a homeodomain-containing transcription factor secreted by prostate cancer into the urine and can be detected by enzyme-linked immunoassay.
Importance of HOX genes in normal prostate gland formation, prostate cancer development and its early detection.
Review
Langley et al., Guildford, United Kingdom. In Bju Int, 2014
The aims of this paper were to review the published literature on the role of HOX genes in the development of the normal prostate gland and in prostate cancer and to discuss the potential role of the HOX family member, Engrailed-2 (EN2), as a diagnostic test of PCa.
EN2: a novel prostate cancer biomarker.
Review
Pandha et al., Guildford, United Kingdom. In Biomark Med, 2013
EN2 is a homeobox-containing transcription factor secreted specifically by prostate cancers into urine, where it can be detected by a simple ELISA assay.
Fragrance material review on 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one.
Review
Api et al., United States. In Food Chem Toxicol, 2013
A toxicologic and dermatologic review of 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one when used as a fragrance ingredient is presented.
Fragrance material review on 1-[5(or 6)-methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one.
Review
Api et al., United States. In Food Chem Toxicol, 2013
A toxicologic and dermatologic review of 1-[5(Or 6)-Methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one when used as a fragrance ingredient is presented.
The WNT2 gene polymorphism associated with speech delay inherent to autism.
GeneRIF
Chiu et al., Taipei, Taiwan. In Res Dev Disabil, 2012
The WNT2 gene and EN2 gene may act in concert to influence the language development in autism.
The engrailed homeobox genes are required in multiple cell lineages to coordinate sequential formation of fissures and growth of the cerebellum.
GeneRIF
Joyner et al., New York City, United States. In Dev Biol, 2012
En1 and En2 act together in multiple cerebellar cell types to determine overall growth and formation of particular fissures.
Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus.
GeneRIF
Deneris et al., Cleveland, United States. In J Neurosci, 2012
En1 is the predominant functional En paralog in maturing 5-HT neurons, although a small contribution from En2 was reproducibly detected
Cut-like homeobox 1 and nuclear factor I/B mediate ENGRAILED2 autism spectrum disorder-associated haplotype function.
GeneRIF
Millonig et al., United States. In Hum Mol Genet, 2012
The data demonstrates that the autism spectrum disorder-associated A-C intronic haplotype of the ENGRAILED2 gene is a transcriptional activator, and both CUX1 and NFIB mediate this activity.
Spatially restricted and developmentally dynamic expression of engrailed genes in multiple cerebellar cell types.
GeneRIF
Joyner et al., New York City, United States. In Cerebellum, 2011
This study characterized En1 and En2 expression around birth and at postnatal day (P) 21 during the period when the cerebellum undergoes a remarkable transformation from a smooth ovoid structure to a highly foliated structure.
Planar induction of anteroposterior pattern in the developing central nervous system of Xenopus laevis.
Impact
Gerhart et al., Berkeley, United States. In Science, 1992
In these, four position-specific neural markers (engrailed-2, Krox-20, XlHbox 1, and XlHbox 6) were expressed in the ectoderm in the same A-P order as in the embryo.
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