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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Engrailed 1

en-1, Engrailed, Engrailed-1
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, ACID, CAN, Hex, CIs
Papers on en-1
Addition of 4-(cyclohex-1-en-1-yl)morpholine on 3-nitroindole: an unprecedented dearomatizing process.
Chataigner et al., Mont-Saint-Aignan, France. In Org Biomol Chem, Feb 2016
UNASSIGNED: Nucleophilic enamines add spontaneously on heteroarenes 3-nitroindole and benzofuran to form a new C-C bond.
Selective oxidation of carotenoid-derived aroma compounds by CYP260B1 and CYP267B1 from Sorangium cellulosum So ce56.
Bernhardt et al., Saarbrücken, Germany. In Appl Microbiol Biotechnol, Feb 2016
Likewise, CYP260B1 performed the allylic hydroxylation of β-damascone [(E)-1-(2,6,6-trimethylcyclohex-1-enyl)but-2-en-1-one] and δ-damascone [(E)-1-(2,6,6-trimethylcyclohex-3-enyl)but-2-en-1-one].
FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice.
Hurley et al., Farmington, United States. In J Cell Biochem, Feb 2016
Wnt inhibitor Engrailed-1 mRNA and protein was increased in HMWTg and was decreased by BGJ398.
Acridone Alkaloids from Swinglea glutinosa (Rutaceae) and Their Effects on Photosynthesis.
Veiga et al., Diadema, Brazil. In Chem Biodivers, Jan 2016
Continuing our search for herbicide models based on natural products, we investigated the action mechanisms of five alkaloids isolated from Swinglea glutinosa (Rutaceae): Citrusinine-I (1), glycocitrine-IV (2), 1,3,5-trihydroxy-10-methyl- 2,8-bis(3-methylbut-2-en-1-yl)-9(10H)-acridinone (3), (2R)-2-tert-butyl-3,10-dihydro-4,9-dihydroxy-11-methoxy-10-methylfuro[3,2-b]acridin-5(2H)-one (4), and (3R)-2,3,4,7-tetrahydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trimethyl-12H-pyrano[2,3-a]acridin-12-one (5) on several photosynthetic activities in an attempt to find new compounds that affect photosynthesis.
Dissecting the role of Engrailed in adult dopaminergic neurons - Insights into Parkinson disease pathogenesis.
Joshi et al., Paris, France. In Febs Lett, Jan 2016
The homeoprotein Engrailed (Engrailed-1/Engrailed-2, collectively En1/2) is not only a survival factor for mesencephalic dopaminergic (mDA) neurons during development, but continues to exert neuroprotective and physiological functions in adult mDA neurons.
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Richards et al., Montréal, Canada. In Nature, Nov 2015
We identified a low-frequency non-coding variant near a novel locus, EN1, with an effect size fourfold larger than the mean of previously reported common variants for lumbar spine BMD (rs11692564(T), MAF = 1.6%, replication effect size = +0.20 s.d., Pmeta = 2 × 10(-14)), which was also associated with a decreased risk of fracture (odds ratio = 0.85; P = 2 × 10(-11); ncases = 98,742 and ncontrols = 409,511).
Computational design of co-assembling protein-DNA nanowires.
Mayo et al., Pasadena, United States. In Nature, Oct 2015
To achieve this, a homodimerization interface is engineered onto the Drosophila Engrailed homeodomain (ENH), allowing the dimerized protein complex to bind to two double-stranded DNA (dsDNA) molecules.
Engrailed homeoproteins in visual system development.
Moya et al., Tübingen, Germany. In Cell Mol Life Sci, Apr 2015
Engrailed is a homeoprotein transcription factor.
Engrailed and tectum development.
Nakamura et al., Fukui, Japan. In Dev Growth Differ, Feb 2015
In this review, function of Engrailed (En) in tectum development is reviewed.
Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso-ene mechanism.
Rutledge et al., Sydney, Australia. In Beilstein J Org Chem, 2014
The combination of N-Boc-hydroxylamine with either FeTPA (1 mol %) or FeBPMEN (10 mol %) converts cyclohexene to the allylic hydroxylamine (tert-butyl cyclohex-2-en-1-yl(hydroxy)carbamate) in moderate yields.
The role of dopaminergic and serotonergic systems in neurodevelopmental disorders: a focus on epilepsy and seizure susceptibility.
Bozzi et al., Trento, Italy. In Bioimpacts, 2014
Importantly, the homeobox-containing genes Otx2, Engrailed-1 (En1), and Engrailed-2 (En2) have been described to crucially regulate differentiation of dopaminergic and serotonergic neurons during vertebrate CNS development.
Postnatal signalling with homeoprotein transcription factors.
Di Nardo et al., Paris, France. In Philos Trans R Soc Lond B Biol Sci, 2014
In this review, we discuss their postnatal and adult physiological functions based on the study of Otx2, Engrailed-1 and Engrailed-2 (collectively Engrailed).
The engrailed homeobox genes are required in multiple cell lineages to coordinate sequential formation of fissures and growth of the cerebellum.
Joyner et al., New York City, United States. In Dev Biol, 2012
En1 and En2 act together in multiple cerebellar cell types to determine overall growth and formation of particular fissures.
Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus.
Deneris et al., Cleveland, United States. In J Neurosci, 2012
Analysis of an allelic series of conditional mutants showed that En1 is the predominant functional En paralog in maturing 5-HT neurons
Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1.
Loomis et al., New York City, United States. In Development, 2012
En1 has a role in regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary
Developmental transcription factor EN1--a novel biomarker in human salivary gland adenoid cystic carcinoma.
El-Naggar et al., Houston, United States. In Cancer, 2012
EN1 is a biologic predictor of poor prognosis in patients with salivary adenoid cystic carcinoma.
Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones.
Moya et al., Paris, France. In Development, 2012
Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones.
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein.
Shiekhattar et al., Philadelphia, United States. In Cell, 2007
We show that JARID1d and Ring6a occupy human Engrailed 2 gene and regulate its expression and H3K4 methylation levels.
The transcription factor Engrailed-2 guides retinal axons.
Holt et al., Paris, France. In Nature, 2005
Engrailed-2 (En-2), a homeodomain transcription factor, is expressed in a caudal-to-rostral gradient in the developing midbrain, where it has an instructive role in patterning the optic tectum--the target of topographic retinal input.
Solution structure of a protein denatured state and folding intermediate.
Fersht et al., Cambridge, United Kingdom. In Nature, 2005
We engineered a mutant of Drosophila melanogaster Engrailed homeodomain that folds and unfolds reversibly just by changing ionic strength.
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