From genetics to treatment of eosinophilic esophagitis.
Philadelphia, United States. In Curr Opin Allergy Clin Immunol, Oct 2015
Genetic studies have shown that EoE is associated with single nucleotide polymorphism on genes, which are released by the epithelium and important in atopic inflammation such as thymic stromal lymphopoietin located (TSLP) close to the Th2 cytokine cluster [interleukin (IL)-4, IL-5, IL-13] on chromosome 5q22, Calpain 14, EMSY, and Eotaxin3.
[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].
In Mol Biol (mosk), 2014
In this study polymorphic variants of PRR genes--Toll-like receptors (TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TLR10), NOD-like receptors (NOD1, NOD2), lipopolysaccharide receptor CD14 gene, and C11orf30 and LRRC32 genes, located in 11q13.5 region, have been investigated in AD patients and control subjects from the Republic of Bashkortostan.
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
Copenhagen, Denmark. In Nat Genet, 2013
We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B.
Expression of EMSY gene in sporadic ovarian cancer.
İstanbul, Turkey. In Mol Biol Rep, 2011
Sporadic ovarian cancer shows overexpression of EMSY at a prevalence similar to that found in breast cancer and the overexpression is correlated with the protein level.
[Genetics of allergic diseases].
Tsukuba, Japan. In Nihon Rinsho, 2009
Recent advances in the genetic technology allow us to perform genome-wide association studies (GWAS), and identified several novel susceptibility genes such as ORMDL3 for childhood asthma and C11orf30 for atopic dermatitis.