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Egf-like module containing, mucin-like, hormone receptor-like 3

EMR3
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: EMR2, CD97, Epidermal Growth Factor, Tropomyosin, EMR1
Papers on EMR3
An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation.
New
Sweet et al., Brisbane, Australia. In Immunobiology, Nov 2013
P2RY8, GPR92, EMR3) have not been widely investigated in macrophage biology and inflammation.
Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination.
Poland et al., Rochester, United States. In Plos One, 2012
Analysis by immune outcome and stimulation status identified 27 genes (p≤0.0006 and FDR≤0.30) that responded differently to viral stimulation in high vs. low antibody responders, including major histocompatibility complex (MHC) class I genes (HLA-A, HLA-B and B2M with p = 0.0001, p = 0.0005 and p = 0.0002, respectively), and two genes related to innate immunity and inflammation (EMR3 and MEFV with p = 1.46E(-08) and p = 0.0004, respectively).
Gene transcription abnormalities in canine atopic dermatitis and related human eosinophilic allergic diseases.
Kita et al., Rochester, United States. In Vet Immunol Immunopathol, 2012
These included: (1) genes associated with alternatively activated monocyte-derived cells, including members of the monocyte chemotactic protein (MCP) gene cluster, (2) members of the IL1 family gene cluster, (3) eosinophil-associated seven transmembrane receptor EMR1 and EMR3 genes, (4) interferon-inducible genes, and (5) keratin genes associated with hair and nail formation.
Genomic alterations in breast cancer patients in betel quid and non betel quid chewers.
Saxena et al., New Delhi, India. In Plos One, 2011
One network "Drug Metabolism, Molecular Transport, Nucleic Acid Metabolism" including genes AKR1B1, AKR1B10, ETS2 etc in BQC and two networks "Molecular Transport, Nucleic Acid Metabolism, Small Molecule Biochemistry" and "Cellular Development, Embryonic Development, Organismal Development" including genes RPN2, EMR3, VAV1, NNAT and MUC16 etc were seen in NBQC.
Molecular profiles and clinical outcome of stage UICC II colon cancer patients.
Hummel et al., Berlin, Germany. In Int J Colorectal Dis, 2011
METHODS: Immunohistochemistry was applied to 68 stage UICC II colon cancers to determine the protein expression of previously published prognostic classifier genes (CDH17, LAT, CA2, EMR3, and TNFRSF11A).
EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target.
GeneRIF
Parsa et al., San Francisco, United States. In Neuroreport, 2010
Given the poor survival associated with high levels of EMR-3 expression in glioma patients, impetus is provided to explore EMR-3 as a potential therapeutic target.
Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease.
Hamann et al., Amsterdam, Netherlands. In Immunol Lett, 2010
Therefore, we determined the expression of CD97, EGF module-containing mucin-like receptor (EMR)2 and EMR3 by monocyte-derived macrophages experimentally polarized in vitro.
High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCV-associated hepatocellular carcinoma.
Fisher et al., Richmond, United States. In Mol Genet Genomics, 2010
When comparing paired HCC tissues to their corresponding pre-neoplastic non-tumorous tissues, eight CpG sites, including one CpG site that was hypermethylated (APC) and seven (NOTCH4, EMR3, HDAC9, DCL1, HLA-DOA, HLA-DPA1, and ERN1) that were hypomethylated in HCC, were identified.
Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.
GeneRIF
Kita et al., Rochester, United States. In Plos One, 2009
Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included increased EMR1&3.
The adhesion GPCRs; gene repertoire, phylogeny and evolution.
Review
Fredriksson et al., Uppsala, Sweden. In Adv Exp Med Biol, 2009
There is a one-to-one relationship of the rodent (mouse and rat) and human orthologues with the exception the EMR2 and EMR3 that do not seem to have orthologues in either rat or mouse.
Identification of novel splice variants of Adhesion G protein-coupled receptors.
Schiöth et al., Uppsala, Sweden. In Gene, 2007
Novel functional splice variants were found for: CD97, CELR3, EMR2, EMR3, GPR56, GPR110, GPR112-GPR114, GPR116, GPR123-GPR126, GPR133, HE6, and LEC1-LEC3.
The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.
GeneRIF
Hamann et al., Amsterdam, Netherlands. In J Leukoc Biol, 2007
The expression of EGF-TM7 receptors on myeloid cells is differentially regulated. EMR3 is the first family member found mainly on granulocytes.
An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2.
Hamann et al., Amsterdam, Netherlands. In Faseb J, 2006
The epidermal growth factor (EGF)-TM7 receptors CD97, EMR1, EMR2, EMR3, and EMR4 form a group of adhesion class heptahelical molecules predominantly expressed by cells of the immune system.
The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.
Schiöth et al., Uppsala, Sweden. In Genomics, 2004
The mouse and human sequences show a clear one-to-one relationship, with the exception of EMR2 and EMR3, which do not seem to have orthologues in mouse.
The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense.
Hamann et al., Amsterdam, Netherlands. In J Immunol, 2004
Family members CD97, EGF module-containing mucin-like receptor (EMR) 1, EMR2, EMR3, EMR4, and EGF-TM7-latrophilin-related protein are characterized by an extended extracellular region with a variable number of N-terminal EGF-like domains.
The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells.
Hamann et al., Amsterdam, Netherlands. In J Leukoc Biol, 2002
Family members CD97, EMR1, EMR2, EMR3, and ETL are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain by a stalk.
Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils.
McKnight et al., Oxford, United Kingdom. In J Biol Chem, 2001
In this study we describe the cloning and characterization of EMR3, a novel human EGF-TM7 molecule, and show the existence of its cellular ligand.
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