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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Egf-like module containing, mucin-like, hormone receptor-like 2

EMR2, CD312
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 3 on chromosome 19. This protein does not interact with the ligand decay accelerating factor for complement, unlike the related CD97 antigen, and indicates that these very closely related proteins likely have nonredundant functions. This gene results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on EMR2
Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains.
GeneRIF
Lin et al., Taiwan. In Mol Cell Biol, 2012
Using the myeloid cell-restricted EMR2 receptor as a paradigm, we exam the mechanistic relevance of the subunit interaction and demonstrate a critical role for autoproteolysis in mediating receptor signaling and cell activation
Epidermal growth factor module-containing mucin-like receptor 2 is a newly identified adhesion G protein-coupled receptor associated with poor overall survival and an invasive phenotype in glioblastoma.
GeneRIF
Parsa et al., San Francisco, United States. In J Neurooncol, 2011
High EMR2 is associated with invasive phenotype in glioblastoma.
EMR2 receptor ligation modulates cytokine secretion profiles and cell survival of lipopolysaccharide-treated neutrophils.
GeneRIF
Lin et al., Taiwan. In Chang Gung Med J, 2011
a functional role for EMR2 in the modulation of neutrophil activation during inflammation.
Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival.
GeneRIF
Fox et al., Oxford, United Kingdom. In Oncol Rep, 2011
The association of improved patient survival with higher nuclear expression levels identifies EMR2 as a potential biomarker in patients with invasive breast cancer.
Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease.
GeneRIF
Hamann et al., Amsterdam, Netherlands. In Immunol Lett, 2010
complex cellular expression programmes rather than activation modes regulate the expression of EGF-TM7 receptors in macrophages
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