DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression.
San Francisco, United States. In Neuro Oncol, 2011
Class 1 (MGMT, PTEN, RASSF1A, TMS1, ZNF342, EMP3, SOCS1, RFX1) was highly methylated in 82% (75/91) of lower-grade astrocytic and oligodendroglial tumors, 73% (8/11) of secondary GBMs, and 12% (6/52) of primary GBMs.
EMP3 as a candidate tumor suppressor gene for solid tumors.
Hiroshima, Japan. In Expert Opin Ther Targets, 2009
BACKGROUND: Epithelial membrane protein 3 (EMP3), was recently reported to be a tumor suppressor gene for several solid tumors, and is drawing attention as a novel prognostic marker, since its expression level or hypermethylation of the promoter region is associated with clinical prognosis in neuroblastoma and esophageal cancer.