Multiple requirements of PLK1 during mouse oocyte maturation.
Czech Republic. In Plos One, 2014
We show that PLK1 is required for the full activation of the anaphase promoting complex/cyclosome (APC/C) by promoting the degradation of the APC/C inhibitor EMI1 and is therefore essential for entry into anaphase I.
Cytostatic factor: an activity that puts the cell cycle on hold.
Martinsried, Germany. In J Cell Sci, 2006
Initially, Xenopus early mitotic inhibitor 1 (Emi1) was proposed to be a component of CSF, but newer work suggests that a structural relative, Emi-related protein 1 (Erp1/Emi2), is essential for maintenance of CSF arrest in Xenopus.