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F-box protein 5

Emi1, early mitotic inhibitor 1, EmII
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: APC, Ubiquitin, PCNA, Plk1, E-cadherin
Papers on Emi1
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
Barford et al., Cambridge, United Kingdom. In Nature, Jul 2015
Its regulation by coactivator subunits, phosphorylation, the mitotic checkpoint complex and interphase early mitotic inhibitor 1 (Emi1) ensures the correct order and timing of distinct cell-cycle transitions.
mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1.
Wang et al., Chongqing, China. In Mol Reprod Dev, Apr 2015
We specifically assessed if extracellular signal-regulated kinase 1/2 (ERK1/2) and/or phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) exert convergent effects toward the activation of mTOR signaling, and if this signaling regulates the expression of SKP2 through retinoblastoma (RB) and early mitotic inhibitor 1 (EMI1) protein and on CCNE1 and CCND1 mRNA levels.
Multiple requirements of PLK1 during mouse oocyte maturation.
Ellenberg et al., Czech Republic. In Plos One, 2014
We show that PLK1 is required for the full activation of the anaphase promoting complex/cyclosome (APC/C) by promoting the degradation of the APC/C inhibitor EMI1 and is therefore essential for entry into anaphase I.
Thymosin beta-4 knockdown in IEC-6 normal intestinal epithelial cells induces DNA re-replication via downregulating Emi1.
Su et al., Taipei, Taiwan. In J Cell Physiol, 2014
Moreover, marked reductions in both RNA and protein levels of Emi1 (early mitotic inhibitor 1) were also detected in Tβ4 -downregulated IEC-6 cells which might be accounted by the downregulation of E2F1, a transcription factor capable of inducing Emi1 expression, mediated by glycogen synthase-3β (GSK-3β).
Helium and lead isotopes reveal the geochemical geometry of the Samoan plume.
Farley et al., Santa Barbara, United States. In Nature, 2014
Each group has a signature associated with one of four mantle endmembers with low (3)He/(4)He: EMII (enriched mantle 2), EMI (enriched mantle 1), HIMU (high µ = (238)U/(204)Pb) and DM (depleted mantle).
NF-κB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS.
Kretz et al., Jena, Germany. In J Cell Sci, 2014
Growth effects mediated by RelA deletion paralleled a downregulation of growth-inhibitory Cdh1 (officially known as FZR1) and upregulation of the endogenous Cdh1 suppressor EMI1 (officially known as FBXO5).
Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis.
Munger et al., Boston, United States. In Virology, 2013
Here we report that the HPV16 E7 oncoprotein interferes with the degradation of APC/C substrates and that the APC/C inhibitor, EMI1, is expressed at higher levels in HPV16 E7-expressing mitotic cells.
Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.
Schulman et al., Memphis, United States. In Nat Struct Mol Biol, 2013
Inhibition of human APC/C(CDH1) during interphase by early mitotic inhibitor 1 (EMI1) is essential for accurate coordination of DNA synthesis and mitosis.
EMI1, a three-in-one ubiquitylation inhibitor.
Yamano, In Nat Struct Mol Biol, 2013
The anaphase-promoting complex/cyclosome (APC/C) is restricted by metazoan protein early mitotic inhibitor 1 (EMI1), a natural, potent inhibitor.
The role of RING box protein 1 in mouse oocyte meiotic maturation.
Sha et al., Nanjing, China. In Plos One, 2012
Moreover, downregulation of Rbx1 caused accumulation of Emi1, an inhibitor of the anaphase-promoting complex/cyclosome (APC/C), which is required for mouse meiotic maturation.
The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions.
Mayer et al., Konstanz, Germany. In Science, 2012
In somatic divisions, the early mitotic inhibitor 1 (Emi1) and the spindle assembly checkpoint (SAC) regulate cell cycle progression by inhibiting the APC/C.
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.
Hershko et al., Haifa, Israel. In J Biol Chem, 2011
the ability of Emi1 to inhibit APC/C is negatively regulated by CDKs
Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells.
Hung et al., Kao-hsiung, Taiwan. In J Cell Physiol, 2011
Results suggest that Bcr-Abl increases Emi1 phosphorylation and stability to prevent Skp2 protein degradation via APC/Cdh1-induced ubiquitination and to enhance proliferation of CML cells.
Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis.
Poon et al., Hong Kong, Hong Kong. In Mol Cell Biol, 2009
Results underscore the crucial role of cyclin A2-CDK2 in regulating the PLK1-SCF(beta-TrCP1)-EMI1-APC/C axis and CDC6 to trigger genome reduplication after the activity of CDK1 is suppressed.
Systematic analysis of the twin cx(9)c protein family.
Riemer et al., Kaiserslautern, Germany. In J Mol Biol, 2009
Loss of Mdm35, Emi1, and Mrp10 leads to abnormal mitochondrial morphology
DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest.
Fotedar et al., Grenoble, France. In Mol Biol Cell, 2009
Emi1 down-regulation and APC activation leads to stable p21-dependent G2 arrest after DNA damage.
Defining the role of Emi1 in the DNA replication-segregation cycle.
Pines et al., Cambridge, United Kingdom. In Chromosoma, 2008
There are several APC/C regulators that restrict its activity to specific cell cycle phases, and amongst these the early mitotic inhibitor 1 (Emi1) protein has recently come to prominence.
Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis.
Strebhardt et al., Denver, United States. In Cancer Res, 2006
Recent evidence suggests that a major role of Plk1 in exit from mitosis is the regulation of inhibitors of the anaphase-promoting complex/cyclosome (APC/C), such as the early mitotic inhibitor 1 (Emi1) and spindle checkpoint proteins.
Cytostatic factor: an activity that puts the cell cycle on hold.
Mayer et al., Martinsried, Germany. In J Cell Sci, 2006
Initially, Xenopus early mitotic inhibitor 1 (Emi1) was proposed to be a component of CSF, but newer work suggests that a structural relative, Emi-related protein 1 (Erp1/Emi2), is essential for maintenance of CSF arrest in Xenopus.
The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.
Jackson et al., Stanford, United States. In Cell, 2006
The anaphase-promoting complex/cyclosome (APC/C) inhibitor Emi1 controls progression to S phase and mitosis by stabilizing key APC/C ubiquitination substrates, including cyclin A. Examining Emi1 binding proteins, we identified the Evi5 oncogene as a regulator of Emi1 accumulation.
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