Holliday junction resolution: regulation in space and time.
London, United Kingdom. In Dna Repair (amst), 2014
A conserved network of core cell-cycle kinases and phosphatases modulate HJ metabolism by exerting spatial and temporal control over the activities of two structure-selective nucleases: yeast Mus81-Mms4 (human MUS81-EME1) and Yen1 (human GEN1).
A blooming resolvase at chromosomal fragile sites.
In Nat Cell Biol, 2013
Now CFS expression is shown to reflect the activity of the MUS81-EME1 resolvase complex which cooperates with the dissolving action of the BLM helicase to prevent uncontrolled chromosome breakage and to promote genome integrity.
MUS81 promotes common fragile site expression.
Oxford, United Kingdom. In Nat Cell Biol, 2013
Here, we report that the DNA structure-specific nuclease MUS81-EME1 localizes to CFS loci in early mitotic cells, and promotes the cytological appearance of characteristic gaps or breaks observed at CFSs in metaphase chromosomes.
Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.
Oxford, United Kingdom. In Cell Cycle, 2012
Here, we review recent work showing that the XPF-ERCC1 endonuclease and the hSNM1A exonuclease act in the same pathway, together with SLX4, to initiate ICL repair, with the MUS81-EME1 fork incision activity becoming important in the absence of the XPF-SNM1A-SLX4-dependent pathway.