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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eukaryotic translation elongation factor 1 alpha 1

Elongation Factor Tu, Elongation Factor 1, EF-Tu, p43
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, ACID, Actin, fibrillin-1
Papers using Elongation Factor Tu antibodies
Physical and computational analysis of the yeast Kluyveromyces lactis secreted proteome
Chong Shaorong et al., In Nucleic Acids Research, 2007
... Participation of the overproduced elongation factor Tu from Thermus thermophilus in protein biosynthesis of ...
Papers on Elongation Factor Tu
Centers of Motion Associated with EF-Tu Binding to the Ribosome.
Fox et al., Houston, United States. In Rna Biol, Feb 2016
This series of measurements is extended here to the ribosome's interactions with the cofactor EF-Tu.
Oxidation of a Cysteine Residue in Elongation Factor EF-Tu Reversibly Inhibits Translation in the Cyanobacterium Synechocystis sp. PCC 6803.
Nishiyama et al., Saitama, Japan. In J Biol Chem, Feb 2016
In the present study, we examined the sensitivity to oxidation by ROS of another elongation factor, EF-Tu.
Increased sensitivity of RT-PCR for Potato virus Y detection using RNA isolated by a procedure with differential centrifugation.
Pelletier et al., Fredericton, Canada. In J Virol Methods, Jan 2016
SYBR Green-based real time RT-PCR showed that the RNA isolated by the DCR method had a higher cycle threshold value (Ct) for the elongation factor 1-α mRNA (Ef1α) of potato than the Ct value of the RNA extracted using the RNeasy plant mini kit, indicating that the DCR method significantly reduced the proportion of potato RNA in the extract.
Prediction of T Cell Epitopes from Leishmania major Potentially Excreted/Secreted Proteins Inducing Granzyme B Production.
Louzir et al., Tunisia. In Plos One, Dec 2015
Six peptides were identified according to their ability to elicit production of granzyme B. Furthermore, among these peptides 3 showed highest affinity to HLA-A*0201, one derived from an elongation factor 1-alpha and two from an unknown protein.
Bacterial Backstabbing: EF-Tu, Brute?
Losick et al., Cambridge, United States. In Cell, Nov 2015
report a new class of toxin that disrupts the core metabolism of recipient cells and uncover a surprising requirement for EF-Tu.
An Interbacterial NAD(P)(+) Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells.
Mougous et al., Seattle, United States. In Cell, Nov 2015
We find that entry of Tse6 into target cells requires its binding to an essential housekeeping protein, translation elongation factor Tu (EF-Tu).
Modeling the mechanisms of biological GTP hydrolysis.
Kamerlin et al., Uppsala, Sweden. In Arch Biochem Biophys, Oct 2015
In addition, the availability of an increasing number of crystal structures of translational GTPases such as EF-Tu and EF-G have made it possible to probe the molecular details of GTP hydrolysis on the ribosome.
Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM.
Stark et al., Göttingen, Germany. In Nature, May 2015
Here we present the cryo-EM structure of the 70S ribosome from Escherichia coli in complex with elongation factor Tu, aminoacyl-tRNA and the antibiotic kirromycin at 2.65-2.9
Stepping Out of the Cytosol: AIMp1/p43 Potentiates the Link Between Innate and Adaptive Immunity.
Decker et al., Houston, United States. In Int Rev Immunol, 2014
Novel studies also show that AIMp1/p43 can be released by certain cancer cells under conditions of stress.
Diagnosis of Fusarium Infections: Approaches to Identification by the Clinical Mycology Laboratory.
Waalwijk et al., Utrecht, Netherlands. In Curr Fungal Infect Rep, 2014
DNA-based diagnostic tools have best discriminatory power when based on translation elongation factor 1-α or the RNA polymerase II second largest subunit.
Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification.
Guo et al., Shanghai, China. In Life (basel), 2014
The interplay between amino acids, tRNA, ATP, EF-Tu and non-canonical binding partners, had shaped each family with distinct pattern of key sites for regulation, with characters varying among species across the path of evolution.
A bacterial tyrosine phosphatase inhibits plant pattern recognition receptor activation.
Zipfel et al., Norwich, United Kingdom. In Science, 2014
Here, we report that the Arabidopsis receptor kinase EF-TU RECEPTOR (EFR), which perceives the elf18 peptide derived from bacterial elongation factor Tu, is activated upon ligand binding by phosphorylation on its tyrosine residues.
Elongation factor G bound to the ribosome in an intermediate state of translocation.
Ramakrishnan et al., Cambridge, United Kingdom. In Science, 2013
The structure provides insights into structural changes that facilitate translocation and suggests a common GTPase mechanism for EF-G and elongation factor Tu.
Identification of a novel binding protein of FAT10: eukaryotic translation elongation factor 1A1.
Shao et al., Nanchang, China. In Dig Dis Sci, 2012
This study identified eEF1A1 as a FAT10-specific binding protein, and when the expression of FAT10 was reduced by siRNA knockdown, this resulted in downregulation of eEF1A1 expression in hepatoma cells.
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.
Ting et al., Chapel Hill, United States. In Immunity, 2012
By recruiting Atg5-Atg12 and NLRX1, TUFM serves as a nodal checkpoint of the RIG-I-MAVS axis. It acts similarly to NLRX1 by inhibiting RigI-like-receptor-induced IFN-I but promoting autophagy.
Hepatitis B virus X protein blocks filamentous actin bundles by interaction with eukaryotic translation elongat ion factor 1 alpha 1.
Lin et al., Fuzhou, China. In J Med Virol, 2012
In Huh-7 hepatoma cells, the hepatitis B virus X protein inhibits dimer formation of eEF1A1, hence blocks filamentous actin bundling.
Molecular markers associated with nonepithelial ovarian cancer in formalin-fixed, paraffin-embedded specimens by genome wide expression profiling.
Mokhtar et al., Kuala Lumpur, Malaysia. In Kaohsiung J Med Sci, 2012
Overexpression of eukaryotic translation elongation factor 1 alpha 1 is associated with nonepithelial ovarian cancer.
Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein.
Herbein et al., Besançon, France. In Cell Death Dis, 2011
The cytoplasmic relocalization of eEF1A, mediated by Exp-t, occurs in Nef-treated monocyte-derived macrophages.
Identification of Surface Proteins from Lactobacillus casei BL23 Able to Bind Fibronectin and Collagen.
Monedero et al., Paterna, Spain. In Probiotics Antimicrob Proteins, 2011
Mass spectrometry analysis of their protein content revealed the presence of stress-related proteins (GroEL, ClpL), translational elongation factors (EF-Tu, EF-G), oligopeptide solute-binding proteins, and the glycolytic enzymes enolase and glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
Expression of the Mucus Adhesion Gene Mub, Surface Layer Protein Slp and Adhesion-Like Factor EF-TU of Lactobacillus acidophilus ATCC 4356 Under Digestive Stress Conditions, as Monitored with Real-Time PCR.
Dicks et al., Stellenbosch, South Africa. In Probiotics Antimicrob Proteins, 2009
Expression of the mucus adhesion gene Mub, surface layer protein Slp and adhesion-like factor EF-Tu by Lactobacillus acidophilus ATCC 4356 grown in the presence of mucin, bile and pancreatin and at low pH was studied using real-time PCR.
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