Elongation Factor 2
Elongation Factor 2
Stoichiometry of Saccharomyces cerevisiae Lysine Methylation: Insights into Non-histone Protein Lysine Methyltransferase Activity.
In J Proteome Res, 12 Mar 2014
By analyzing 8 sites of methylation in 3 non-histone proteins - elongation factor 1-α (EF1α), elongation factor 2 (EF2) and 60S ribosomal protein L42-A/B (Rpl42ab) - we find that: production of preferred methylation states on individual lysine residues is commonplace, and likely occurs through processive PKMT activity; Class I PKMTs can be associated with processive methylation; lysine residues are selectively methylated by specific PKMTs; and lysine methylation exists over a broad range of stoichiometries.
Structures of the human and Drosophila 80S ribosome.
München, Germany. In Nature, Jun 2013
Here we present structures of Drosophila melanogaster and Homo sapiens 80S ribosomes in complex with the translation factor eEF2, E-site transfer RNA and Stm1-like proteins, based on high-resolution cryo-electron-microscopy density maps.
Is sporadic Alzheimer's disease associated with diphtheria toxin?
Bethesda, United States. In J Alzheimers Dis, 2012
An association with diphtheria toxin was suggested by observations that vaccinations may provide protective effects, and the observation that decreased proteins synthesis in cortical regions from AD patients is associated with modification of elongation factor 2, the target of diphtheria toxin.
Synaptic mechanisms underlying rapid antidepressant action of ketamine.
Dallas, United States. In Am J Psychiatry, 2012
They focus on their recent work demonstrating that ketamine-mediated blockade of NMDA receptors at rest deactivates eukaryotic elongation factor 2 (eEF2) kinase, resulting in reduced eEF2 phosphorylation and desuppression of rapid dendritic protein translation, including BDNF (brain-derived neurotrophic factor), which then contributes to synaptic plasticity mechanisms that mediate longterm effects of the drug.