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Eukaryotic translation elongation factor 2

Elongation Factor 2, EF-2, NPR-C, eEF2
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NPR, CAN, V1a, mTOR, ACID
Papers using Elongation Factor 2 antibodies
Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells.
Khromykh Alexander, In PLoS Pathogens, 2000
... Doms), anti-tubulin (Sigma), and anti-P-AMPK, t-AMPK, P-ACC, t-ACC, P-eEF2, t-eEF2 (Cell Signaling Technology) ...
Papers on Elongation Factor 2
Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening.
Cho et al., Austin, United States. In Methods Mol Biol, 31 Dec 2015
Protein kinases have emerged as an important class of therapeutic targets, as they are known to be involved in pathological pathways linked to numerous human disorders.
Acute resistance exercise activates rapamycin-sensitive and insensitive mechanisms that control translational activity and capacity in skeletal muscle.
Baar et al., Davis, United States. In J Physiol, 09 Dec 2015
REx also altered pathways that regulate protein homeostasis and mRNA translation in a manner that was both rapamycin-sensitive (proteasome activity; phosphorylation of S6K1 and rpS6) and insensitive (phosphorylation of eEF2, ERK1/2 and UBF; gene expression of the myostatin target Mighty as well as c-Myc and its targets involved in ribosome biogenesis).
Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome.
Ferrer et al., l'Hospitalet de Llobregat, Spain. In Brain Pathol, 29 Nov 2015
Several genes encoding ribosomal proteins are abnormally regulated and protein levels of translation initiation factors eIF2α, eIF3η and eIF5, and elongation factor eEF2, are altered in the CA1 region in AD.
BDNF- a Key Transducer of Antidepressant Effects.
Monteggia et al., Stockholm, Sweden. In Neuropharmacology, 28 Nov 2015
Ketamine has been shown to increase BDNF translation by blocking NMDA receptor activity at rest, thereby inhibiting calcium influx and subsequently halting eukaryotic elongation factor 2 (eEF2) kinase leading to a desuppression of protein translation, including BDNF translation.
Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule-related proteins in neurons.
Proud et al., Vancouver, Canada. In J Neurochem, 20 Nov 2015
Elongation is primarily regulated via eukaryotic elongation factor 2 kinase (eEF2K).
The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family.
Merrill et al., Guelph, Canada. In Toxins (basel), Aug 2015
We showed that cholix toxin is specific for elongation factor 2 (diphthamide residue), similar to exotoxin A and diphtheria toxin.
The mechanics of ribosomal translocation.
Nierhaus et al., Berlin, Germany. In Biochimie, Jul 2015
The movement of the million-dalton complex ribosome is triggered by the universal elongation factor G (EF2 in archaea and eukaryotes) and is termed translocation.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Gilbert et al., New York City, United States. In Nature, Jul 2015
DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis.
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
Sansom et al., Paris, France. In Nature, Feb 2015
Mechanistically, mTORC1-mediated inhibition of eEF2 kinase is required for the proliferation of APC-deficient cells.
Global protein profiling studies of chikungunya virus infection identify different proteins but common biological processes.
Smith, Bangkok, Thailand. In Rev Med Virol, Jan 2015
Remarkably, only a single protein, eukaryotic elongation factor 2, has been identified by more than two different groups as being differentially regulated during CHIKV infection.
Fibronectin-, vitronectin- and laminin-binding proteins at the cell walls of Candida parapsilosis and Candida tropicalis pathogenic yeasts.
Rapala-Kozik et al., Kraków, Poland. In Bmc Microbiol, Dec 2014
The major individual compounds of the fungal cell wall that bound fibronectin, vitronectin and laminin were found to comprise two groups: (1) true cell wall components similar to C. albicans adhesins from the Als, Hwp and Iff/Hyr families; and (2) atypical (cytoplasm-derived) surface-exposed proteins, including malate synthase, glucose-6-phosphate isomerase, 6-phosphogluconate dehydrogenase, enolase, fructose-1,6-bisphosphatase, transketolase, transaldolase and elongation factor 2. DISCUSSION: The adhesive abilities of two investigated non-albicans Candida species toward extracellular matrix proteins were comparable to those of C. albicans suggesting an important role of this particular virulence attribute in the pathogenesis of infections caused by C. tropicalis and C. parapsilosis.
The diphthamide modification pathway from Saccharomyces cerevisiae--revisited.
Stark et al., Leicester, United Kingdom. In Mol Microbiol, Dec 2014
Diphthamide is a conserved modification in archaeal and eukaryal translation elongation factor 2 (EF2).
Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome.
Ramakrishnan et al., Cambridge, United Kingdom. In Cell, Jun 2014
Translocation of the IRES by elongation factor 2 (eEF2) is required to bring the first codon of the mRNA into the A site and to allow the start of translation.
Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds.
Charney et al., Bethesda, United States. In Annu Rev Pharmacol Toxicol, 2013
These clinical findings have been reverse-translated into preclinical models in an effort to elucidate ketamine's antidepressant mechanism of action, and three important targets have been identified: mammalian target of rapamycin (mTOR), eukaryotic elongation factor 2 (eEF2), and glycogen synthase kinase-3 (GSK-3).
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.
Sorensen et al., Vancouver, Canada. In Cell, 2013
We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation.
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development.
Leppla et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development
In vitro and in vivo protection by melatonin against the decline of elongation factor-2 caused by lipid peroxidation: preservation of protein synthesis.
Ayala et al., Sevilla, Spain. In J Pineal Res, 2012
melatonin prevented the molecular changes in eEF-2 and the decline in protein synthesis rate secondary to lipid peroxidation.
C-type natriuretic peptide and its receptors in atherosclerotic plaques of the carotid artery of clinically asymptomatic patients.
Eckstein et al., München, Germany. In Eur J Vasc Endovasc Surg, 2012
Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery, with increased expression of NPR3 in histologically unstable plaques.
Prolyl hydroxylase-dependent modulation of eukaryotic elongation factor 2 activity and protein translation under acute hypoxia.
Pascual et al., Sevilla, Spain. In J Biol Chem, 2012
PHD2 modulated eEF2 activity and protein translation under acute hypoxia.
Knockdown of natriuretic peptide receptor-A enhances receptor C expression and signalling in vascular smooth muscle cells.
Anand-Srivastava et al., Montréal, Canada. In Cardiovasc Res, 2012
knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C.
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