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Eukaryotic translation elongation factor 2

Elongation Factor 2, EF-2, NPR-C, eEF2
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NPR, CAN, V1a, mTOR, ACID
Papers using Elongation Factor 2 antibodies
Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells.
Supplier
Khromykh Alexander, In PLoS Pathogens, 2000
... Doms), anti-tubulin (Sigma), and anti-P-AMPK, t-AMPK, P-ACC, t-ACC, P-eEF2, t-eEF2 (Cell Signaling Technology) ...
Papers on Elongation Factor 2
Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.
New
Brinkmann et al., Penzberg, Germany. In Proc Natl Acad Sci U S A, 25 Sep 2015
The diphthamide on human eukaryotic translation elongation factor 2 (eEF2) is the target of ADP ribosylating diphtheria toxin (DT) and Pseudomonas exotoxin A (PE).
Enhanced anti-colon cancer immune responses with modified eEF2-derived peptides.
New
Gao et al., Qingdao, China. In Cancer Lett, 21 Sep 2015
UNASSIGNED: Eukaryotic elongation factor-2 (eEF2) is overexpressed in many human cancers and is an attractive target for cancer immunotherapy.
Diurnal gene expression of lipolytic natriuretic peptide receptors in white adipose tissue.
New
Goetze et al., Copenhagen, Denmark. In Endocr Connect, 18 Sep 2015
Tissue mRNA contents of natriuretic peptide receptors NPR-A and, NPR-C, and the clock genes Per-1 and B-mal 1, and transcripts involved in lipid metabolism were quantified at 4-hour intervals during 24 hours in two groups of mice: In the diurnal study, mice were exposed to a period of 12 hours' light followed by 12 hours' darkness (n=52).
60S ribosomal protein L35 regulates β-casein translational elongation and secretion in bovine mammary epithelial cells.
New
Zheng et al., Dalian, China. In Arch Biochem Biophys, 18 Sep 2015
We found that RPL35 could control ribosome translational elongation during synthesis of CSN2 by interacting with eukaryotic translational elongation factor 2 (eEF2), and that eEF2 was the signaling molecule downstream of RPL35 controlling this process.
The mechanics of ribosomal translocation.
Review
New
Nierhaus et al., Berlin, Germany. In Biochimie, 31 Jul 2015
The movement of the million-dalton complex ribosome is triggered by the universal elongation factor G (EF2 in archaea and eukaryotes) and is termed translocation.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
New
Impact
Gilbert et al., New York City, United States. In Nature, 18 Jul 2015
DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis.
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
New
Impact
Sansom et al., Paris, France. In Nature, Feb 2015
Mechanistically, mTORC1-mediated inhibition of eEF2 kinase is required for the proliferation of APC-deficient cells.
The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family.
Review
New
Merrill et al., Guelph, Canada. In Toxins (basel), Dec 2014
We showed that cholix toxin is specific for elongation factor 2 (diphthamide residue), similar to exotoxin A and diphtheria toxin.
Pseudomonas aeruginosa Expresses a Functional Human Natriuretic Peptide Receptor Ortholog: Involvement in Biofilm Formation.
New
Lesouhaitier et al., Évreux, France. In Mbio, Dec 2014
Furthermore, the human NPR-C receptor agonist cANF(4-23) mimics the effects of natriuretic peptides on P. aeruginosa, while sANP, the NPR-A receptor agonist, appears to be weakly active.
Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome.
New
Impact
Ramakrishnan et al., Cambridge, United Kingdom. In Cell, Jun 2014
Translocation of the IRES by elongation factor 2 (eEF2) is required to bring the first codon of the mRNA into the A site and to allow the start of translation.
Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles.
Review
New
Proud et al., Southampton, United Kingdom. In Adv Biol Regul, May 2014
Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'α-kinases'.
[Ketamine's antidepressant effect: focus on ketamine mechanisms of action].
Review
New
Gaillard et al., Paris, France. In Encephale, Feb 2014
Intracellular signaling pathways such as mTOR, GSK3 or eEF2 seem to play a key role and are associated with an increased synaptic plasticity.
Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons.
Review
Sala et al., Milano, Italy. In Front Cell Neurosci, 2013
Worthy of note, there is accumulating evidence that the eukaryotic Elongation Factor 2 Kinase (eEF2K)/eukaryotic Elongation Factor 2 (eEF2) pathway may be strongly involved in this process.
Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds.
Review
Impact
Charney et al., Bethesda, United States. In Annu Rev Pharmacol Toxicol, 2013
These clinical findings have been reverse-translated into preclinical models in an effort to elucidate ketamine's antidepressant mechanism of action, and three important targets have been identified: mammalian target of rapamycin (mTOR), eukaryotic elongation factor 2 (eEF2), and glycogen synthase kinase-3 (GSK-3).
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.
Impact
Sorensen et al., Vancouver, Canada. In Cell, 2013
We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation.
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development.
GeneRIF
Leppla et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development
In vitro and in vivo protection by melatonin against the decline of elongation factor-2 caused by lipid peroxidation: preservation of protein synthesis.
GeneRIF
Ayala et al., Sevilla, Spain. In J Pineal Res, 2012
melatonin prevented the molecular changes in eEF-2 and the decline in protein synthesis rate secondary to lipid peroxidation.
C-type natriuretic peptide and its receptors in atherosclerotic plaques of the carotid artery of clinically asymptomatic patients.
GeneRIF
Eckstein et al., München, Germany. In Eur J Vasc Endovasc Surg, 2012
Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery, with increased expression of NPR3 in histologically unstable plaques.
Prolyl hydroxylase-dependent modulation of eukaryotic elongation factor 2 activity and protein translation under acute hypoxia.
GeneRIF
Pascual et al., Sevilla, Spain. In J Biol Chem, 2012
PHD2 modulated eEF2 activity and protein translation under acute hypoxia.
Knockdown of natriuretic peptide receptor-A enhances receptor C expression and signalling in vascular smooth muscle cells.
GeneRIF
Anand-Srivastava et al., Montréal, Canada. In Cardiovasc Res, 2012
knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C.
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