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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Dec 2014.

Eukaryotic translation elongation factor 2

Elongation Factor 2, EF-2, NPR-C, eEF2
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NPR, CAN, V1a, ACID, mTOR
Papers using Elongation Factor 2 antibodies
Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells.
Khromykh Alexander, In PLoS Pathogens, 2000
... Doms), anti-tubulin (Sigma), and anti-P-AMPK, t-AMPK, P-ACC, t-ACC, P-eEF2, t-eEF2 (Cell Signaling Technology) ...
Papers on Elongation Factor 2
Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation.
Duronio et al., Vancouver, Canada. In Can J Cardiol, 31 Dec 2014
We tested whether loss of eukaryotic elongation factor 2 kinase (eEF2K) activity in macrophages suppresses development of atherosclerosis by transplanting bone marrow from mice with mutant eEF2K into ldlr(-/-) mice.
Sepsis attenuates the anabolic response to skeletal muscle contraction.
Lang et al., State College, United States. In Shock, 24 Dec 2014
Conversely, sepsis did not appear to modulate protein elongation as eEF2 Thr phosphorylation was decreased similarly by muscle contraction in both groups.
Metastable behavior of noble gas inserted tin and lead fluorides.
Chattaraj et al., Kharagpur, India. In Phys Chem Chem Phys, 19 Dec 2014
Except for FKrEF3, the dissociations of FNgSnF3 and FNgEF, producing Ng and SnF4 or EF2, are only exergonic in nature at room temperature, whereas FNgPbF3 has a thermochemical instability with respect to two two-body dissociation channels.
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
Sansom et al., Paris, France. In Nature, 05 Dec 2014
Mechanistically, mTORC1-mediated inhibition of eEF2 kinase is required for the proliferation of APC-deficient cells.
Structural effects of Mg(2+) on the regulatory states of three neuronal calcium sensors operating in vertebrate phototransduction.
Dell'Orco et al., Verona, Italy. In Biochim Biophys Acta, 04 Dec 2014
Finally, MD simulations suggest that the GCAP1 state harboring one Mg(2+) ion bound to EF2 acquires structural characteristics that are thought to be relevant for the activation of the guanylate cyclase.
Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome.
Ramakrishnan et al., Cambridge, United Kingdom. In Cell, Jun 2014
Translocation of the IRES by elongation factor 2 (eEF2) is required to bring the first codon of the mRNA into the A site and to allow the start of translation.
A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.
Dinan et al., Cork, Ireland. In J Affect Disord, Mar 2014
Efforts to unravel ketamine's therapeutic mechanism of action have implicated the mammalian target of rapamycin (mTOR)-dependent synapse formation in the rat prefrontal cortex, eukaryotic elongation factor 2 phosphorylation (p-eEF2) and glycogen synthase kinase (GSK-3).
[Ketamine's antidepressant effect: focus on ketamine mechanisms of action].
Gaillard et al., Paris, France. In Encephale, Feb 2014
Intracellular signaling pathways such as mTOR, GSK3 or eEF2 seem to play a key role and are associated with an increased synaptic plasticity.
The C2238/αANP Variant Is a Negative Modulator of Both Viability and Function of Coronary Artery Smooth Muscle Cells.
Volpe et al., Isernia, Italy. In Plos One, Dec 2013
NPR-C gene silencing with specific siRNAs restored cell viability, miR21 expression, and reduced oxidative stress induced by CC2238/αANP.
Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds.
Charney et al., Bethesda, United States. In Annu Rev Pharmacol Toxicol, Dec 2013
These clinical findings have been reverse-translated into preclinical models in an effort to elucidate ketamine's antidepressant mechanism of action, and three important targets have been identified: mammalian target of rapamycin (mTOR), eukaryotic elongation factor 2 (eEF2), and glycogen synthase kinase-3 (GSK-3).
Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons.
Sala et al., Milano, Italy. In Front Cell Neurosci, Dec 2013
Worthy of note, there is accumulating evidence that the eukaryotic Elongation Factor 2 Kinase (eEF2K)/eukaryotic Elongation Factor 2 (eEF2) pathway may be strongly involved in this process.
The biosynthesis and biological function of diphthamide.
Lin et al., Ithaca, United States. In Crit Rev Biochem Mol Biol, Nov 2013
Eukaryotic and archaeal elongation factor 2 contains a unique post-translationally modified histidine residue, named diphthamide.
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.
Sorensen et al., Vancouver, Canada. In Cell, Jun 2013
We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation.
Structures of the human and Drosophila 80S ribosome.
Beckmann et al., München, Germany. In Nature, Jun 2013
Here we present structures of Drosophila melanogaster and Homo sapiens 80S ribosomes in complex with the translation factor eEF2, E-site transfer RNA and Stm1-like proteins, based on high-resolution cryo-electron-microscopy density maps.
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development.
Leppla et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development
In vitro and in vivo protection by melatonin against the decline of elongation factor-2 caused by lipid peroxidation: preservation of protein synthesis.
Ayala et al., Sevilla, Spain. In J Pineal Res, 2012
melatonin prevented the molecular changes in eEF-2 and the decline in protein synthesis rate secondary to lipid peroxidation.
C-type natriuretic peptide and its receptors in atherosclerotic plaques of the carotid artery of clinically asymptomatic patients.
Eckstein et al., München, Germany. In Eur J Vasc Endovasc Surg, 2012
Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery, with increased expression of NPR3 in histologically unstable plaques.
Prolyl hydroxylase-dependent modulation of eukaryotic elongation factor 2 activity and protein translation under acute hypoxia.
Pascual et al., Sevilla, Spain. In J Biol Chem, 2012
PHD2 modulated eEF2 activity and protein translation under acute hypoxia.
Knockdown of natriuretic peptide receptor-A enhances receptor C expression and signalling in vascular smooth muscle cells.
Anand-Srivastava et al., Montréal, Canada. In Cardiovasc Res, 2012
knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C.
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