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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

ELKS/RAB6-interacting/CAST family member 1

ELKS, ERC1
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Munc13, RIM1, CAN, RET, V1a
Papers on ELKS
Diacylglycerol Guides the Hopping of Clathrin-Coated Pits along Microtubules for Exo-Endocytosis Coupling.
New
Chen et al., Beijing, China. In Dev Cell, Nov 2015
A dynamic cortical microtubular network, anchored at the cell surface by the cytoplasmic linker-associated protein on microtubules and the LL5β/ELKS complex on the plasma membrane, provides the track for CCP hopping.
Oxidative stress shapes breast cancer phenotype through chronic activation of ATM-dependent signaling.
New
Brown et al., Gainesville, United States. In Breast Cancer Res Treat, May 2015
Here we show that, in MDA-MB-231 and HeLa cells, basal ATM-dependent NF-κB activation occurs through a canonical DNA damage-responsive signaling pathway as knockdown of two proteins involved in this signaling pathway, ERC1 and TAB1, results in loss of NF-κB basal activity.
A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones.
Sigrist et al., Berlin, Germany. In Elife, 2014
Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot (BRP) and RIM-binding protein (RBP).
The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons.
Kaeser et al., Boston, United States. In J Neurosci, 2014
Vertebrate ELKS proteins are enriched at presynaptic active zones, but their functions are not well understood.
Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration.
de Curtis et al., Milano, Italy. In J Cell Sci, 2014
ERC1a (an isoform of ERC1) and the LL5 proteins LL5α and LL5β (encoded by PHLDB1 and PHLDB2, respectively) are required, together with liprin-α1, for effective migration and tumor cell invasion, and do so by stabilizing the protrusive activity at the cell front.
A 1.5Mb terminal deletion of 12p associated with autism spectrum disorder.
Sotomaior et al., Curitiba, Brazil. In Gene, 2014
This 12p13.33 deletion is 1.5Mb in size and encompasses 13 genes (B4GALNT3, CCDC77, ERC1, FBXL14, IQSEC3, KDM5A, LINC00942, LOC574538, NINJ2, RAD52, SLC6A12, SLC6A13 and WNK1).
Liprin-α/SYD-2 determines the size of dense projections in presynaptic active zones in C. elegans.
Eimer et al., Göttingen, Germany. In J Cell Biol, 2014
Whereas loss of syd-2 function led to smaller DPs, syd-2 gain-of-function mutants displayed larger ribbonlike DPs through increased recruitment of ELKS-1/ELKS.
Lateral mobility of presynaptic α7-containing nicotinic receptors and its relevance for glutamate release.
Berg et al., Göttingen, Germany. In J Neurosci, 2013
The effects on release require functional α7-nAChRs and may to depend on CAST/ELKS (calpastatin/glutamine, leucine, lysine, and serine-rich protein), which an unbiased proteomic screen yielded.
Active zones of mammalian neuromuscular junctions: formation, density, and aging.
Review
Nishimune, Kansas City, United States. In Ann N Y Acad Sci, 2012
VDCCs interact extracellularly with the muscle-derived synapse organizer, laminin β2 and interact intracellularly with active zone-specific proteins, such as Bassoon, CAST/Erc2/ELKS2alpha, ELKS, Piccolo, and RIMs.
The presynaptic active zone.
Review
Südhof, Stanford, United States. In Neuron, 2012
Active zones are composed of an evolutionarily conserved protein complex containing as core constituents RIM, Munc13, RIM-BP, α-liprin, and ELKS proteins.
Critical roles of IĸB kinase subunits in mast cell degranulation.
Review
Nakajima et al., Chiba, Japan. In Int Arch Allergy Immunol, 2011
In addition to IKK2, a recent study has shown that ELKS, a regulatory subunit of the IKK complex, also induces the degranulation of rat basophilic leukemia cells.
Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site.
GeneRIF
Kilimann et al., Uppsala, Sweden. In Proc Natl Acad Sci U S A, 2011
Data show that Bassoon colocalizes with Aczonin at conventional synapses, but in ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, and Aczonin is positioned and may control the access of neurotransmitter vesicles to the fusion site.
[Molecular mechanism at the presynaptic active zone].
Review
Ohtsuka, Japan. In Brain Nerve, 2011
Presently, the full molecular composition of AZ is unclear, but it is known to contain several AZ-specific proteins, including cytomatrix of the active zone-associated protein (CAST)/ERC2, ELKS, RIM1, Munc13-1, Piccolo/Aczonin, and Bassoon.
ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
GeneRIF
Tergaonkar et al., Memphis, United States. In Mol Cell, 2010
ATM- and NEMO-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1/TAB2/3 and NEMO/IKK complexes, resulting in IKK and NF-kappaB activation following genotoxic stimuli.
CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone.
Review
Ohtsuka et al., Japan. In J Biochem, 2010
However, it still remains elusive how CAST and ELKS regulate the assembly and function of AZ during synapse maturation.
Involvement of ELKS, an active zone protein, in exocytotic release from RBL-2H3 cells.
GeneRIF
Hirashima et al., Tanabe, Japan. In Cell Immunol, 2008
ELKS positively regulates exocytotic release in RBL-2H3 by acting on the plasma membrane upon stimulation.
A PDGFRB-positive acute myeloid malignancy with a new t(5;12)(q33;p13.3) involving the ERC1 gene.
GeneRIF
Mecucci et al., In Leukemia, 2008
ERC1-PDGFRB fusion is associated with acute myeloid leukemia
ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells.
GeneRIF
Takai et al., Kyoto, Japan. In Genes Cells, 2006
ELKS is involved in Ca(2+)-dependent exocytosis from PC12 cells
Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.
Impact
Miyamoto et al., Madison, United States. In Science, 2006
ATM is also exported in a NEMO-dependent manner to the cytoplasm, where it associates with and causes the activation of IKK in a manner dependent on another IKK regulator, a protein rich in glutamate, leucine, lysine, and serine (ELKS).
Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.
Impact
GeneRIF
Verma et al., Los Angeles, United States. In Science, 2004
ELKS likely functions by recruiting IkappaBalpha to the IkappaB kinase (IKK) complex and thus serves a regulatory function for IKK activation
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