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E74-like factor 5

Elf5, ESE-2
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, BIRC5, CDX2, EHF, ACID
Papers on Elf5
The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.
Pacherník et al., Brno, Czech Republic. In Chem Biol Interact, Feb 2016
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
Ormandy et al., Australia. In Plos Biol, Dec 2015
During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell.
ELF5 isoform expression is tissue-specific and significantly altered in cancer.
Ormandy et al., Sydney, Australia. In Breast Cancer Res, Dec 2015
BACKGROUND: E74-like factor 5 (ELF5) is an epithelial-specific member of the E26 transforming sequence (ETS) transcription factor family and a critical regulator of cell fate in the placenta, pulmonary bronchi, and milk-producing alveoli of the mammary gland.
Dendrobium candidum inhibits MCF-7 cells proliferation by inducing cell cycle arrest at G2/M phase and regulating key biomarkers.
Hu et al., Changchun, China. In Onco Targets Ther, Dec 2015
The messenger RNA levels of estrogen receptor alpha, IGFBP2, IGFBP4, and GATA3 were significantly decreased, and the messenger RNA and protein levels of ELF5, p53, p21, p18, CDH1, CDH2, and p12 were significantly increased, compared to the control group (P<0.05).
Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges.
Ratnam et al., Detroit, United States. In Oncotarget, Nov 2015
Among estrogen-regulated genes, progestin/PR-A counter-regulated a distinctive subset, including breast tumor progression genes (e.g., HES1, PRKCH, ELF5, TM4SF1), leading to invasiveness.
An autoregulatory enhancer controls mammary-specific STAT5 functions.
Hennighausen et al., Bethesda, United States. In Nucleic Acids Res, Nov 2015
This region exhibited several hallmarks of genomic enhancers, including DNaseI hypersensitivity, H3K27 acetylation and binding by GR, NFIB, ELF5 and MED1.
Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts.
Rao et al., Raleigh, United States. In J Biol Chem, May 2015
We have examined hESC-derived trophoblasts in the light of stringent criteria that were proposed recently, such as hypomethylation of the ELF5-2b promoter region and down-regulation of HLA class I antigens.
Whole genome expression profiling in chewing-tobacco-associated oral cancers: a pilot study.
Saranath et al., Mumbai, India. In Med Oncol, Mar 2015
The biological functions and representative deregulated genes include cell proliferation (AIM2, FAP, TNFSF13B, TMPRSS11A); signal transduction (FOLR2, MME, HTR3B); invasion and metastasis (SPP1, TNFAIP6, EPHB6); differentiation (CLEC4A, ELF5); angiogenesis (CXCL1); apoptosis (GLIPR1, WISP1, DAPL1); and immune responses (CD300A, IFIT2, TREM2); and metabolism (NNMT; ALDH3A1).
E74-like factor inhibition induces reacquisition of hormone sensitiveness decreasing period circadian protein homolog 1 expression in prostate cancer cells.
Azuma et al., Ōsaka, Japan. In Prostate Int, Mar 2015
Among them, we focused on a novel Ets transcription factor, E74-like factor 5 (ELF5), the expression level of which was extremely high in C4-2 in comparison with LNCaP both in the microarray analysis and real-time polymerase chain reaction analysis, and investigated the biological role in acquisition of androgen-refractory PCa growth.
Polymorphisms of EHF-ELF5 genomic region and its association with pediatric asthma in the Taiwanese population.
Wu et al., Tainan City, Taiwan. In J Microbiol Immunol Infect, 2015
BACKGROUND: The EHF and ELF5 genes, located on chromosome 11p and linked to asthma phenotypes, are high-potential candidate genes conferring asthma susceptibility.
The Efficient Derivation of Trophoblast Cells from Porcine In Vitro Fertilized and Parthenogenetic Blastocysts and Culture with ROCK Inhibitor Y-27632.
Li et al., Hohhot, China. In Plos One, 2014
The expression of TR lineage markers, such as CDX2, KRT7, KRT18, TEAD4, ELF5 and HAND1, imprinted genes such as IGF2, PEG1 and PEG10, and telomerase activity related genes TERC and TERF2 were detected by immunofluorescence staining, reverse transcription PCR and quantitative real-time PCR analyses.
Transcriptome profiling of bovine inner cell mass and trophectoderm derived from in vivo generated blastocysts.
Sirard et al., Eşfahān, Iran. In Bmc Dev Biol, 2014
Moreover, a great majority of genes that were found to be misregulated following in vitro culture of bovine embryos were known genes involved in epigenetic regulation of pluripotency and cell differentiation including DNMT1, GADD45, CARM1, ELF5 HDAC8, CCNB1, KDM6A, PRDM9, CDX2, ARID3A, IL6, GADD45A, FGFR2, PPP2R2B, and SMARCA2.
Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication.
Schaal et al., Düsseldorf, Germany. In Retrovirology, 2014
Formation of the Tat-encoding mRNAs requires splicing at the viral 3'ss A3, which has previously been shown to be both negatively and positively regulated by the downstream splicing regulatory elements (SREs) ESS2p and ESE2/ESS2.
Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling.
Sinha et al., Princeton, United States. In Stem Cells, 2012
Studies suggest that Elf5 loss leads to hyperactivation of the Notch signaling pathway, which might constitute in part, the underlying molecular mechanism for the altered cell lineage decisions in Elf5-null mammary epithelial cells.
Elf5 regulation in the trophectoderm.
Pfeffer et al., Hamilton, New Zealand. In Dev Biol, 2012
Elf5 regulation in the trophectoderm
Lineage specific methylation of the Elf5 promoter in mammary epithelial cells.
Ormandy et al., Australia. In Stem Cells, 2011
Elf5 promoter methylation is regulated during mammary differentiation in vivo.
The Ets transcription factor ELF5 functions as a tumor suppressor in the kidney.
Pritchard et al., Australia. In Twin Res Hum Genet, 2011
Loss of ELF5 is associated with kidney cancer.
Signal transducer and activator of transcription 5 as a key signaling pathway in normal mammary gland developmental biology and breast cancer.
Cabrera et al., Washington, D.C., United States. In Breast Cancer Res, 2010
In normal development, STAT5 expression and activity are regulated by prolactin signaling with JAK2/ELF5, EGF signaling networks that include c-Src, and growth hormone, insulin growth factor, estrogen, and progesterone signaling pathways.
Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of Elf5.
Pritchard et al., Australia. In Plos One, 2009
identify novel transcriptional targets of Elf5 and show that Muc4 is a direct target of Elf5, further elucidating the mechanisms through which Elf5 regulates proliferation and differentiation in the mammary gland
The epithelial-specific Ets factors occupy a unique position in defining epithelial proliferation, differentiation and carcinogenesis.
Watson et al., Charleston, United States. In Anticancer Res, 2003
These Epithelial-specific Ets (Ese) factors, cluster into two groups based on the sequence of the Ets DNA binding domain: (i) Ese1, Ese2 and Ese3, and (ii) the more divergent, Pdef.
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