Adipose stem cells isolated from excised burned tissue: is there potential for clinical use?
Newark, United States. In Plast Reconstr Surg, Feb 2016
A human study described the use of these cells spread on collagen-elastin scaffolds placed under skin grafts in patients that had excision of their wounds down to the fascia, resulting in ninety percent viability.This emerging therapy is encouraging as these cells may represent a source of autologous multipotent cells that could help burn patients' wound healing without increasing their morbidity by performing additional fat harvesting procedures.
Evolution of the fish heart by sub/neofunctionalization of an elastin gene.
Tokyo, Japan. In Nat Commun, Dec 2015
Here we reveal that the teleost-specific extracellular matrix (ECM) gene, elastin b, was generated by the teleost-specific whole-genome duplication and neofunctionalized to contribute to acquisition of the BA by regulating cell fate determination of cardiac precursor cells into smooth muscle.
Recombinant protein-based polymers for advanced drug delivery.
Salt Lake City, United States. In Chem Soc Rev, 2012
Research into elastin-like, silk-like, and silk-elastinlike protein polymers for example has led to the development of delivery systems based on natural motifs of structural proteins to take advantage of their physicochemical properties.