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Chymotrypsin-like elastase family, member 3B

elastase, Pancreatic Elastase
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, myeloperoxidase, V1a
Papers using elastase antibodies
Enzymatically Degradable Mussel-Inspired Adhesive Hydrogel
Supplier
Messersmith Phillip B. et al., In Biomacromolecules, 2010
... Mouse-reactive anti-rabbit neutrophil elastase was purchased from Abcam, (Cambridge, MA), and the ...
The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease
Supplier
Bingle Colin D. et al., In Histochemistry and Cell Biology, 2010
... David Thornton, University of Manchester, UK; final dilution 1:250); monoclonal antibodies to CD68 and neutrophil elastase purchased from Dako (1:400 and 1:300, respectively), ...
Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata
Supplier
Chiang Hsiu-Mei et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2009
... Collagenase, elastase substrate IV, elastase inhibitor I, and porcine elastase were purchased from Calbiochem, Merck (San Diego, Calif, USA) ...
Adherent neutrophils activate endothelial myosin light chain kinaserole in transendothelial migration
Supplier
Lindbom Lennart et al., In The Journal of Experimental Medicine, 1997
... Sheep IgG against human elastase was from The Binding Site, and rabbit IgG against ...
Peroxynitrite mediates IL-8 gene expression and production in lipopolysaccharide-stimulated human whole blood
Supplier
Benarafa Charaf, In PLoS ONE, 1997
... Antibodies and suppliers were as follows: rabbit polyclonal anti elastase (IgG, Calbiochem, San Diego, California, USA), chicken anti rabbit Alexa fluor 488 (IgG, Molecular probes, Eugene, Oregon, USA), goat polyclonal anti human IL-1β (IgG, Santa Cruz Biotechnology, Santa Cruz, California, USA), ...
Papers on elastase
Carrageenan-induced inflammation promotes ROS generation and neutrophil extracellular trap formation in a mouse model of peritonitis.
New
Donadio et al., Porto Alegre, Brazil. In Eur J Immunol, Feb 2016
UNASSIGNED: Neutrophil extracellular traps (NETs) are a combination of DNA fibers and granular proteins, such as neutrophil elastase (NE).
COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species.
New
Hansbro et al., Newcastle, Australia. In Respirology, Feb 2016
Supernatants were assessed for neutrophil elastase (NE) and IL-1β.
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines.
New
Martin et al., Dublin, Ireland. In Cell Rep, Feb 2016
Here, we show that IL-36α, IL-36β, and IL-36γ are activated differentially by the neutrophil granule-derived proteases cathepsin G, elastase, and proteinase-3, increasing their biological activity ∼500-fold.
SerpinB1 Promotes Pancreatic β Cell Proliferation.
New
Impact
Kulkarni et al., Boston, United States. In Cell Metab, Feb 2016
Small-molecule compounds, that partially mimic serpinB1 effects of inhibiting elastase activity, enhanced proliferation of β cells, and mice lacking serpinB1 exhibit attenuated β cell compensation in response to insulin resistance.
Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma.
New
Kim et al., Seoul, South Korea. In Pulm Pharmacol Ther, Feb 2016
The levels of neutrophil elastase, Interleukin (IL)-8, and BRP-39 (human homologue YKL-40) were assessed.
Human neutrophil elastase inhibition studied by capillary electrophoresis with laser induced fluorescence detection (LIF) and microscale thermophoresis (MST).
New
Morin et al., Orléans, France. In J Chromatogr A, Feb 2016
UNASSIGNED: Capillary electrophoresis-laser induced fluorescence (CZE-LIF) and microscale thermophoresis (MST) were used for the first time to study the inhibition of human neutrophil elastase (HNE).
Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease.
Review
New
Sorsa et al., Helsinki, Finland. In Innate Immun, Jan 2016
MMP-8, MMP-9 and neutrophil elastase).
Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response.
Review
New
Cichy et al., Kraków, Poland. In Cytokine Growth Factor Rev, Jan 2016
First described as an inhibitor of serine proteases such as neutrophil elastase, this protein is increasingly recognized as a molecule that benefits the host via its anti-proteolytic, anti-microbial and immunomodulatory activities.
Therapeutic Potential to Modify the Mucus Barrier in Inflammatory Bowel Disease.
Review
New
Li et al., Nanjing, China. In Nutrients, Dec 2015
We also review the involvement of the mucus barrier in the exacerbation of the disease and explore the therapeutic potential of modifying the mucus barrier with short-chain fatty acids, prebiotics, probiotics, fatty acid synthase, H₂S, neutrophil elastase inhibitor and phophatidyl choline.
Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function.
Review
New
Tomomura et al., Sakado, Japan. In World J Biol Chem, Dec 2015
This secreted serine protease has chymotrypsin-like activity and is also known as chymotrypsin C; it belongs to the elastase family.
Blood tests for acute pancreatitis.
Review
New
Ratnam et al., Melbourne, Australia. In Aust Prescr, Aug 2015
New biomarkers including trypsinogen and elastase have no significant advantage over amylase or lipase.
Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo.
New
Impact
Nourshargh et al., Genève, Switzerland. In Immunity, Jul 2015
Local proteolytic cleavage of EC JAM-C by neutrophil elastase (NE) drove this cascade of events as supported by presentation of NE to JAM-C via the neutrophil adhesion molecule Mac-1.
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
New
Impact
Kuner et al., Heidelberg, Germany. In Nat Med, May 2015
T lymphocytes infiltrate the DRG after nerve injury and release leukocyte elastase (LE), which was inhibited by SerpinA3N derived from DRG neurons.
Dietary modulation of the microbiome affects autoinflammatory disease.
Impact
Kanneganti et al., Memphis, United States. In Nature, 2015
We further demonstrate that combined deletion of caspases 1 and 8 was required for protection against IL-1β-dependent inflammatory bone disease, whereas the deletion of either caspase alone or of elastase or neutrophil proteinase 3 failed to prevent inflammatory disease.
Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens.
Impact
Papayannopoulos et al., London, United Kingdom. In Nat Immunol, 2014
Phagocytosis via dectin-1 acted as a sensor of microbe size and prevented NET release by downregulating the translocation of neutrophil elastase (NE) to the nucleus.
Partial pancreatic resection for pancreatic malignancy is associated with sustained pancreatic exocrine failure and reduced quality of life: a prospective study.
GeneRIF
Ghaneh et al., Liverpool, United Kingdom. In Pancreatology, 2010
FE-1 is a poor surrogate for diagnosing impaired fat absorption.
Identification of pancreatic juice proteins as biomarkers of pancreatic cancer.
GeneRIF
Ma et al., Shanghai, China. In Oncol Rep, 2010
Hypermethylation of ELA3B gene promoter were associated with pancreatic cancer.
Parathormone levels and Vitamin D metabolism in female patients with various grades of fecal elastase 1 deficiency.
GeneRIF
Klör et al., Ludwigshafen am Rhein, Germany. In Eur J Med Res, 2009
Parathormone levels and Vitamin D metabolism in female patients with various grades of fecal ELA1 deficiency are reported.
Low fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus.
GeneRIF
Lankisch et al., Germany. In Pancreas, 2008
Neither low fecal elastase 1 nor raised fecal fat levels reliably indicate exocrine pancreatic insufficiency in type-1 diabetes.
Fecal elastase 1 and vitamin D3 in patients with osteoporotic bone fractures.
GeneRIF
Teichmann et al., Gießen, Germany. In Eur J Med Res, 2008
Reduced fecal elastase 1 connected with lowered serum levels of vitamin D3 is associated with osteoporotic bone fractures.
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