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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eukaryotic translation initiation factor 4B

eIF4B, eukaryotic translation initiation factor 4B, TIF3
Top mentioned proteins: eIF4E, CAN, ACID, mTOR, p70S6K
Papers using eIF4B antibodies
The armadillo protein p0071 regulates Rho signalling during cytokinesis
Supplier
Hatzfeld Mechthild et al., In The Journal of Cell Biology, 2005
... (BD), vinculin, Flag, plakoglobin (Sigma-Aldrich), eIF4A1 (Santa Cruz Biotechnology, Inc.), HA (Rockland), myc (Dianova), and eIF4B (Cell Signaling Technology) ...
Papers on eIF4B
Eukaryotic Initiation Factor eIFiso4G1 and eIFiso4G2 Are Isoforms Exhibiting Distinct Functional Differences in Supporting Translation in Arabidopsis.
New
Gallie, Riverside, United States. In J Biol Chem, Feb 2016
Although many eukaryotes express two eIF4G isoforms that are highly similar, the eIF4G isoforms in plants, referred to as eIF4G and eIFiso4G, are highly divergent in size, sequence, and domain organization but both can interact with eIF4A, eIF4B, eIF4E isoforms, and the poly(A)-binding protein.
The pseudorabies virus vhs protein cleaves RNA containing an IRES sequence.
New
Hsu et al., T'ai-chung-shih, Taiwan. In Febs J, Feb 2016
Moreover, the addition of the translation initiation factors eIF4H and eIF4B significantly increased the RNase activity of recombinant PrV vhs against capped RNA.
Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.
New
Bernards et al., Amsterdam, Netherlands. In Sci Rep, Dec 2015
Using the somatic mutation rate and eIF4B protein level, we identified three groups with different clinical outcomes, including a group with extremely good prognosis.
eIF4F: a retrospective.
Review
New
Merrick, Cleveland, United States. In J Biol Chem, Nov 2015
Since that time, numerous studies have been performed with the three proteins specifically required for the translation initiation of natural mRNAs, eIF4A, eIF4B, and eIF4F.
Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo.
New
Wickens et al., Madison, United States. In Rna, Jul 2015
Reporters bearing IRES elements revealed that repression via tethered CAF1 and Xp54 is cap- and eIF4E-independent, but requires one or more of eIF4A, eIF4B, and eIF4G.
RNA BIOCHEMISTRY. Factor-dependent processivity in human eIF4A DEAD-box helicase.
New
Impact
Block et al., Stanford, United States. In Science, Jul 2015
Using a single-molecule assay, we found that eIF4A functions instead as an adenosine triphosphate-dependent processive helicase when complexed with two accessory proteins, eIF4G and eIF4B.
Search for genes responsible for the remarkably high acetic acid tolerance of a Zygosaccharomyces bailii-derived interspecies hybrid strain.
Sá-Correia et al., Lisbon, Portugal. In Bmc Genomics, 2014
CONCLUSIONS: ISA1307 genes homologous to S. cerevisiae genes GYP8, WSC4, PMT1, KTR7, RKR1, TIF3, ILV3 and MSN4 are proposed as strong candidate determinants of acetic acid tolerance.
C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B-Dependent Signalling and Boosted by Increased Protein Stability in Models of Monocytic Differentiation.
Brand et al., Hannover, Germany. In Plos One, 2014
Remarkably, LAP*/LAP expression was dependent on phosphorylated eIF4B, an acceleratory protein of RNA helicase eIF4A.
The role of the poly(A) binding protein in the assembly of the Cap-binding complex during translation initiation in plants.
Review
Gallie, Riverside, United States. In Translation (austin), 2014
eIF4B promotes the ATP-dependent RNA helicase activity of eIF4A and eIF4F needed to unwind secondary structure present in a 5'-leader that would otherwise impede scanning of the 40 S subunit during initiation.
Phosphorylation of eukaryotic translation initiation factor 4B (EIF4B) by open reading frame 45/p90 ribosomal S6 kinase (ORF45/RSK) signaling axis facilitates protein translation during Kaposi sarcoma-associated herpesvirus (KSHV) lytic replication.
GeneRIF
Zhu et al., Tallahassee, United States. In J Biol Chem, 2012
ORF45/RSK axis-induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSHV lytic replication.
Dual nature of translational control by regulatory BC RNAs.
GeneRIF
Tiedge et al., New York City, United States. In Mol Cell Biol, 2011
C-loops bind to eIF4B and prevent the factor's interaction with 18S rRNA of the small ribosomal subunit.
Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B.
GeneRIF
Fraser et al., Davis, United States. In J Mol Biol, 2011
Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B.
mRNA helicases: the tacticians of translational control.
Review
Impact
GeneRIF
Sonenberg et al., Montréal, Canada. In Nat Rev Mol Cell Biol, 2011
Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR.
Mechanisms of mRNA translation of interferon stimulated genes.
Review
Platanias et al., Chicago, United States. In Cytokine, 2010
In addition, MAPKs are known to regulate the phosphorylation of various eukaryotic initiation factors and we summarize the roles of eIF4B and eIF4E phosphorylations on the translation of ISGs.
Functional interactions between mRNA turnover and surveillance and the ubiquitin proteasome system.
Review
Brooks, United States. In Wiley Interdiscip Rev Rna, 2010
eIF4E-BP (4E-BP) is differentially regulated by the proteasome: truncated to generate a protein with higher eIF4B binding or completely degraded, depending on its phosphorylation status.
Uncoupling stress granule assembly and translation initiation inhibition.
GeneRIF
Mazroui et al., Québec, Canada. In Mol Biol Cell, 2009
Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation.
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.
Impact
Blenis et al., Boston, United States. In Cell, 2005
Phosphorylation results in S6K1 dissociation, activation, and subsequent phosphorylation of its translational targets, including eIF4B, which is then recruited into the complex in a phosphorylation-dependent manner.
The joining of ribosomal subunits in eukaryotes requires eIF5B.
Impact
Hellen et al., New York City, United States. In Nature, 2000
The resulting complex requires eIF1, eIF1A, eIF4A, eIF4B and eIF4F to bind to a messenger RNA and to scan to the initiation codon.
Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.
Impact
Hellen et al., New York City, United States. In Nature, 1998
In their absence, 43S ribosomal preinitiation complexes incubated with ATP, eIF4A, eIF4B and eIF4F bind exclusively to the cap-proximal region but are unable to reach the initiation codon.
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