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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eukaryotic translation initiation factor 4A2

EIF4A2, eIF4AII, heIF4AII, eukaryotic initiation factor 4AII
Top mentioned proteins: eIF4E, CAN, POLYMERASE, ACID, CYC1
Papers on EIF4A2
Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence.
Review
New
Quesne et al., Leicester, United Kingdom. In Biochem Soc Trans, Jan 2016
Such mRNAs have been shown to possess longer and more structured 5'-UTRs requiring high levels of eukaryotic initiation factor 4A (eIF4A) helicase activity for efficient translation.
eIF4AII is dispensable for miRNA-mediated gene silencing.
New
Pelletier et al., Montréal, Canada. In Rna, Oct 2015
Using the CRISPR/Cas9-editing system, we generated a novel cell line in which expression of eIF4AII was eliminated.
Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro.
Alsner et al., Århus, Denmark. In Plos One, 2014
Acidosis resulted in a more wide-scale change in gene expression profiles than hypoxia including upregulation of genes involved in the translation process, for example Eukaryotic translation initiation factor 4A, isoform 2 (EIF4A2), and Ribosomal protein L37 (RPL37).
Differential Gene Expression Reveals Candidate Genes for Drought Stress Response in Abies alba (Pinaceae).
Liepelt et al., Marburg an der Lahn, Germany. In Plos One, 2014
Furthermore, we could show that some traditional reference genes from model plant species (GAPDH and eIF4A2) are not suitable for differential analysis and we propose a new reference gene, TPC1, for drought stress expression profiling in needles of conifer seedlings.
MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans.
Fujiwara et al., Nagoya, Japan. In Mol Cell, 2014
Strikingly, miRISC-induced release of eIF4AI and eIF4AII from target mRNAs and miRISC-induced inhibition of cap-dependent translation can both be counteracted by the RNA-binding protein HuD via a direct interaction of HuD with eIF4A.
The diverse roles of the eIF4A family: you are the company you keep.
Review
Bushell et al., Leicester, United Kingdom. In Biochem Soc Trans, 2014
Three eIF4A proteins have been characterized in vertebrates: eIF4A1 and eIF4A2 are cytoplasmic, whereas eIF4A3 is nuclear-localized.
Identification of protein interaction partners in mammalian cells using SILAC-immunoprecipitation quantitative proteomics.
Goodfellow et al., Cambridge, United States. In J Vis Exp, 2013
As an example this technique is applied to identify proteins binding to the eukaryotic translation initiation factors: eIF4AI and eIF4AII.
Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation.
Pelletier et al., Montréal, Canada. In Plos One, 2013
The presence of two cellular eIF4A isoforms, eIF4AI and eIF4AII, has long thought to impart equivalent functions to eIF4F.
Reference gene selection for quantitative real-time PCR normalization in Reaumuria soongorica.
Ma et al., Lanzhou, China. In Plos One, 2013
After validation of the ribulose-1,5-bisphosphate carboxylase/oxygenase large unite (rbcL) expression pattern, our data suggested that histone H2A (H2A) and eukaryotic initiation factor 4A-2 (EIF4A2) were the most stable reference genes, cyclophilin (CYCL) was moderate, and elongation factor 1α (EF1α) was the worst choice.
Downregulation of EIF4A2 in non-small-cell lung cancer associates with poor prognosis.
Qinian et al., Guangzhou, China. In Clin Lung Cancer, 2013
BACKGROUND: EIF4A2, which belongs to the eukaryotic initiation factor 4A family, is a highly conserved gene for one of the protein-synthesis initiation factors involved in the binding of messenger RNA to the ribosome.
De novo methyltransferase, OsDRM2, interacts with the ATP-dependent RNA helicase, OseIF4A, in rice.
Kapoor et al., New Delhi, India. In J Mol Biol, 2013
Interaction between Arabidopsis eIF4AI and eIF4AII with OsDRM2 and nuclear localization of these complexes suggests possible conservation of functional interaction between de novo methyltransferases and the translation initiation factor, eIF4A, in RdDM across plant species.
Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation.
Impact
Bushell et al., Leicester, United Kingdom. In Science, 2013
We define the RNA helicase eIF4A2 as the key factor of eIF4F through which miRNAs function.
mRNA decay during herpes simplex virus (HSV) infections: mutations that affect translation of an mRNA influence the sites at which it is cleaved by the HSV virion host shutoff (Vhs) protein.
Read et al., Kansas City, United States. In J Virol, 2013
Vhs binds the translation initiation factors eIF4H, eIF4AI, and eIF4AII, suggesting that its mRNA degradative function is somehow linked to translation.
Variation in stability of housekeeping genes in healthy and adhesion-related mesothelium.
Cheong et al., Southampton, United Kingdom. In Fertil Steril, 2012
The stability of 12 candidate reference genes in the mesothelial tissues were evaluated; these include ATP5b, SDHA, CYC1, 18S rRNA, RPL13A, ACTB, YWHAZ, TOP1, UBC, EIF4A2, GAPDH, and B2M.
A cellular response linking eIF4AI activity to eIF4AII transcription.
GeneRIF
Pelletier et al., Montréal, Canada. In Rna, 2012
The results indicated that eIF4AI and eIF4AII expression are linked and that the two protein isoforms exhibit functional differences.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
mRNA helicases: the tacticians of translational control.
Impact
GeneRIF
Sonenberg et al., Montréal, Canada. In Nat Rev Mol Cell Biol, 2011
Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR.
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.
GeneRIF
Dias-Neto et al., São Paulo, Brazil. In J Neural Transm, 2009
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
c-Myc and eIF4F are components of a feedforward loop that links transcription and translation.
GeneRIF
Pelletier et al., Montréal, Canada. In Cancer Res, 2008
A feedforward loop involving c-Myc and eIF4F that serves to link transcription and translation and that could contribute to the effects of c-Myc on cell proliferation and neoplastic growth.
Nonstructural protein 5B of hepatitis C virus.
Review
Myung et al., South Korea. In Mol Cells, 2006
Cellular proteins interacting with NS5B include VAMP-associated proteins, heIF4AII, hPLIC1, nucleolin, PRK2, a-actinin, and p68 helicase.
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