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Eukaryotic translation initiation factor 3, subunit H

eIF3h, EIF3S3, eIF3-p40, Eukaryotic translation initiation factor 3 subunit 3
Encodes eukaryotic initiation factor 3H1 subunit (TIF3H1). (from NCBI)
Top mentioned proteins: c-Myc, p63, CAN, eIF3f, 48-kDa
Papers on eIF3h
Biological insights into the expression of translation initiation factors from recombinant CHOK1SV cell lines and their relationship to enhanced productivity.
New
Smales et al., Andover, United States. In Biochem J, Jan 2016
We have determined mRNA and protein levels of the key components of the closed loop, eIFs (eIF3a, eIF3b, eIF3c, eIF3h, eIF3i and eIF4G1), poly(A)-binding protein (PABP) 1 and PABP-interacting protein 1 (PAIP1), across a panel of 30 recombinant mAb-producing GS-CHOK1SV cell lines with a broad range of growth characteristics and production levels of a model recombinant mAb.
Prenatal diagnosis and array comparative genomic hybridization characterization of interstitial deletions of 8q23.3-q24.11 and 8q24.13 associated with Langer-Giedion syndrome, Cornelia de Lange syndrome and haploinsufficiency of TRPS1, RAD21 and EXT1.
New
Wang et al., Taipei, Taiwan. In Taiwan J Obstet Gynecol, Oct 2015
encompassing six OMIM genes, TRPS1, EIF3H, RAD21, SLC30A8, MED30, and EXT1, and a 1.383-Mb deletion of 8q24.13 encompassing four OMIM genes, ZHX2, DERL1, ZHX1, and ATAD2.
A subset of genetic susceptibility variants for colorectal cancer also has prognostic value.
New
Galvan et al., Milano, Italy. In Pharmacogenomics J, Jun 2015
Two additional SNPs associated with TTR, namely rs16892766 (downstream of EIF3H) and rs10749971 (COLCA2).
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.
Couch et al., Detroit, United States. In Hum Mol Genet, 2014
P = 4.2 × 10(-10)) and EIF3H (rs799890: OR = 1.07, 95% CI 1.04-1.11,
The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.
Smales et al., Davis, United States. In Biochem J, 2014
In the present study, we show that the eukaryotic cytosolic chaperonin CCT [chaperonin containing TCP-1 (tailless complex polypeptide 1)] binds to newly synthesized eIF3b and promotes the correct folding of eIF3h and eIF3i.
A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.
Bernard-Pierrot et al., In Carcinogenesis, 2014
Four of six other candidate driver genes-RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3
Translational control of Arabidopsis meristem stability and organogenesis by the eukaryotic translation factor eIF3h.
von Arnim et al., Knoxville, United States. In Plos One, 2013
In this study, it is shown that mutation of a translation initiation factor, eIF3h, causes a tendency to develop a strikingly enlarged shoot apical meristem with elevated and ectopic expression of WUS and CLAVATA3 (CLV3).
The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.
Watts et al., Brighton, United Kingdom. In Plos One, 2013
Here we have focussed on two translation initiation factors that we identified as co-purifying with Ulp2, eIF4G and eIF3h.
The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.
Zhu et al., Key West, United States. In J Biol Chem, 2013
Two of the subunits, eIF3f and eIF3h, are stabilized by eIF3m through subcomplex formation.
The global translation profile in a ribosomal protein mutant resembles that of an eIF3 mutant.
von Arnim et al., Knoxville, United States. In Bmc Biol, 2012
First, the ribosome occupancy defects in the rpl24b mutant partially overlapped with those in a previously analyzed initiation factor mutant, eif3h.
Human-like eukaryotic translation initiation factor 3 from Neurospora crassa.
Cate et al., Berkeley, United States. In Plos One, 2012
Eukaryotic translation initiation factor 3 (eIF3) is a key regulator of translation initiation, but its in vivo assembly and molecular functions remain unclear.
Allelic variation at the 8q23.3 colorectal cancer risk locus functions as a cis-acting regulator of EIF3H.
GeneRIF
Houlston et al., United Kingdom. In Plos Genet, 2010
Increased expression of EIF3H gene increases colorectal cancer growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association.
MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib.
GeneRIF
Gemmill et al., Rozzano, Italy. In J Thorac Oncol, 2009
MYC and EIF3H are frequently coamplified in NSCLC and that a high copy number correlates with increased epidermal growth factor receptor tyrosine kinase inhibitors sensitivity.
Measles virus interaction with host cells and impact on innate immunity.
Review
Valentin et al., Lyon, France. In Curr Top Microbiol Immunol, 2008
The virus N protein interacts with eIF3-p40 to inhibit the translation of cellular mRNA.
Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation.
GeneRIF
Maitra et al., New York City, United States. In Yeast, 2008
eIF3h deletion mutants are hypersensitive to caffeine and highly defective in meiosis, producing either no spores or incomplete tetrads with a very high frequency.
An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3.
GeneRIF
Hershey et al., Davis, United States. In J Biol Chem, 2008
high eIF3h levels directly stimulate protein synthesis, resulting in the establishment and maintenance of the malignant state in cells.
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
Impact
Houlston et al., London, United Kingdom. In Nat Genet, 2008
In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H.
On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation.
GeneRIF
von Arnim et al., Knoxville, United States. In Genome Biol, 2006
The intact eIF3h protein contributes to efficient translation initiation on 5' leader sequences harboring multiple uORFs.
The molecular genetics of prostate cancer.
Review
Visakorpi, Tampere, Finland. In Urology, 2003
Recent findings have also implicated Kruppel-like factor 6 (KFL6), E-cadherin, the p40 subunit of eukaryotic translation initiation factor (eIF3-p40), and Elongin C, but confirmatory evidence is required to clarify the roles of these factors.
Molecular cytogenetics of prostate cancer.
Review
Visakorpi et al., Tampere, Finland. In Microsc Res Tech, 2001
For example, amplifications of AR (at Xq12), MYC (8q24), and EIF3S3 (8q23) have been found in a large fraction of hormone-refractory prostate cancer by FISH.
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