[Endoplasmic reticulum-mediated integrated stress response].
Beijing, China. In Sheng Li Ke Xue Jin Zhan, 2013
Integrated stress response (ISR) is a high conserved cell adaptive response, which is induced by oxidative stress, deprivation of acid aminos, and endoplasmic reticulum (ER) stress through eukaryotic translation initiator factor 2alpha (eIF2alpha) pathway.
RNA granules: the good, the bad and the ugly.
Buenos Aires, Argentina. In Cell Signal, 2011
PBs are constitutive, but respond to stimuli that affect mRNA translation and decay, whereas SGs are specifically induced upon cellular stress, which triggers a global translational silencing by several pathways, including phosphorylation of the key translation initiation factor eIF2alpha, and tRNA cleavage among others.
Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention.
Indianapolis, United States. In Cell Metab, 2009
In this issue of Cell Metabolism, Kaufman and colleagues (Back et al., 2009) elegantly demonstrate that appropriate regulation of eIF2alpha phosphorylation improves glucose tolerance and beta cell viability by preventing the lethal buildup of oxidative damage due to unregulated synthesis, trafficking, and misfolding of proteins.