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EH-domain containing 3

This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Eps15, CAN, EHD4, Actin, V1a
Papers on EHD2
Possible regulation of caveolar endocytosis and flattening by phosphorylation of F-BAR domain protein PACSIN2/Syndapin II.
Suetsugu et al., Helsinki, Finland. In Bioarchitecture, Feb 2016
PACSIN2 is thought to function in the scission and stabilization of caveolae, through binding to dynamin-2 and EHD2, respectively.
The HIV-1 protein Vpr impairs phagosome maturation by controlling microtubule-dependent trafficking.
Niedergang et al., Paris, France. In J Cell Biol, Nov 2015
We showed that maturation arrest occurred at the level of the EHD3/MICAL-L1 endosomal sorting machinery.
Identification of Differentially Expressed Proteins of Normal and Cancerous Human Colorectal Tissues by Liquid Chromatograph-Mass Spectrometer Based on iTRAQ Approach.
Gao et al., Luoyang, China. In Cancer Invest, Nov 2015
EHD2 were selected to verify its expression patterns and localization using western blotting and immunohistochemistry respectively.
Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer.
Polenakovic et al., Скопје, Macedonia. In Prostate, Oct 2015
Thirteen of the identified proteins, namely, constituents of the intermediate filaments (KRT8, KRT18, DES), potential tumor suppressors (ARHGAP1, AZGP1, GSTM2, and MFAP4), transport and membrane organization proteins (FABP5, GC, and EHD2), chaperons (FKBP4 and HSPD1) and known cancer marker (NME1) have been associated with prostate and other cancers by numerous proteomics, genomics or functional studies.
Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane.
Suetsugu et al., Tokyo, Japan. In J Cell Sci, Sep 2015
Furthermore, expression of EHD2, which stabilizes caveolae and binds to PACSIN2, restored the tracking durations of cells with reduced PACSIN2 levels.
Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.
Mohler et al., Omaha, United States. In J Biol Chem, Jun 2015
We previously linked the C-terminal Eps15 homology domain-containing protein 3 (EHD3) with endosome-based protein trafficking in ventricular cardiomyocytes.
Role of EHD2 in migration and invasion of human breast cancer cells.
He et al., Shanghai, China. In Tumour Biol, May 2015
Eps15 homology domain-containing 2 (EHD2) is a tumor suppressor gene, overexpressed in several solid tumors, including ovarian cancer and esophageal squamous cell carcinoma.
Decreased expression and prognostic role of EHD2 in human breast carcinoma: correlation with E-cadherin.
Wang et al., Yancheng, China. In J Mol Histol, Apr 2015
The aim of this study was to examine the effect of C-Terminal EH domain-containing protein 2 (EHD2) expression on E-cadherin and related mechanism in the metastasis of breast cancer.
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.
Westlake et al., Frederick, United States. In Nat Cell Biol, Mar 2015
Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, function in early ciliogenesis.
SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.
Horowitz et al., Tel Aviv-Yafo, Israel. In Plos One, 2014
Of the four mammalian EHDs (EHD1-EHD4) EHD1 and EHD3 control traffic to the endocytic recycling compartment (ERC) and from the ERC to the plasma membrane, while EHD2 modulates internalization.
Role of the EHD2 unstructured loop in dimerization, protein binding and subcellular localization.
Caplan et al., Omaha, United States. In Plos One, 2014
In contrast, despite EHD2 having nearly 70% amino acid identity with its paralogs, EHD1, EHD3 and EHD4, the latter proteins contain a single KPF or RPF motif, but no NPF motif.
Identification of gene regulation patterns underlying both oestrogen- and tamoxifen-stimulated cell growth through global gene expression profiling in breast cancer cells.
Jordan et al., Washington, D.C., United States. In Eur J Cancer, 2014
4-OHT was more potent than E2 in up-regulating some membrane remodelling molecules, such as EHD2, FHL2, HOMER3 and RHOF.
Genetic analysis of ion-beam induced extremely late heading mutants in rice.
Sato et al., Kagoshima, Japan. In Breed Sci, 2014
FLT2 was located around the centromere of chromosome 9. FLT1 might share the same locus as EHD3 because their chromosomal location is overlapping.
Scratching the surface: actin' and other roles for the C-terminal Eps15 homology domain protein, EHD2.
Caplan et al., Omaha, United States. In Histol Histopathol, 2014
Of the four mammalian EHD proteins, EHD2 appears to be the most disparate, both in terms of sequence homology, and in subcellular localization/function.
EHD2 shuttles to the nucleus and represses transcription.
Horowitz et al., Tel Aviv-Yafo, Israel. In Biochem J, 2012
Among three EHD proteins (EHD1-EHD3) that were tested, only EHD2 accumulates in the nucleus under nuclear export inhibition treatment.
Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin.
Helenius et al., Zürich, Switzerland. In Embo J, 2012
Confining caveolae to the plasma membrane by EHD2 relied on its capacity to link caveolae to actin filaments.
Differential regulation of EHD3 in human and mammalian heart failure.
Mohler et al., Iowa City, United States. In J Mol Cell Cardiol, 2012
EHD3 is a previously unrecognized component of the cardiac remodeling pathway in heart failure.
EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization.
Lundmark et al., Umeå, Sweden. In Mol Biol Cell, 2012
Assembly of EHD2 stabilized and constrained caveolae to the plasma membrane to control turnover, and depletion of EHD2, resulting in endocytic and more dynamic and short-lived caveolae.
A study of the combined effects of the EHD3 and FREM3 genes in patients with major depressive disorder.
Xu et al., Beijing, China. In Am J Med Genet B Neuropsychiatr Genet, 2012
The combined effect of the EHD3 and FREM3 genes may play an important role in developing major depressive disorder.
Modeling membrane shaping by proteins: focus on EHD2 and N-BAR domains.
Kozlov et al., Tel Aviv-Yafo, Israel. In Febs Lett, 2010
We especially consider models for membrane bending and fission by EHD2 proteins and membrane bending by N-BAR domains.
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