gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Heart and neural crest derivatives expressed 1

EH and, HAND1
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, fibrillin-1, Angiotensin II
Papers on EH and
Role of natural organic matter on iodine and (239)(,240)Pu distribution and mobility in environmental samples from the northwestern Fukushima Prefecture, Japan.
Santschi et al., Galveston, United States. In J Environ Radioact, Feb 2016
Other soil chemical properties, such as Eh and pH, had strong correlations to soil (127)I content, but only within a given land use (e.g., within urban soils).
MicroRNA-194 Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1.
Beretta et al., Houston, United States. In Stem Cells, Feb 2016
Overexpression of miR-194 in hESCs induced their spontaneous differentiation, a phenotype accompanied with accelerated loss of the pluripotent factors OCT4 and NANOG and decrease in mesoderm marker HAND1 expression.
HO-1/CO system and embryonic stem cell differentiation and maturation into cardiomyocytes.
Piantadosi et al., Durham, United States. In Antioxid Redox Signal, Feb 2016
Targeted HO-1/CO interventions up- and down-regulate specific cardiogenic transcription factors GATA4, Nkx2.5, Hand1, and MEF2C.
Contribution of ellagic acid on the antioxidant potential of medicinal plant Epilobium hirsutum.
Adali et al., Konya, Turkey. In Nutr Cancer, Jan 2016
Wistar rats were intraperitoneally treated with 37.5 mg/kg of EH and 10 mg/kg of EA for 9 days.
[Effects of Water and Nitrogenous Fertilizer Coupling on CH4 and N2O Emission from Double-Season Rice Paddy Field].
Long et al., In Huan Jing Ke Xue, Sep 2015
Through correlation analysis it found that CH4 emissions from soil were significantly related with soil solution Eh and solution CH4 concentration.
Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development.
Sachinidis et al., Köln, Germany. In Int J Cardiol, Apr 2015
The expression of cardiac specific transcription factors, such as Gata4, Tbx5, Tbx20, Tbx2, Tbx3, Mef2c, Hey1 and Hand1 are of fundamental significance for the in-vivo cardiac development.
Dysregulation of T cell subsets in the pathogenesis of hypertension.
Agrawal et al., Omaha, United States. In Curr Hypertens Rep, Feb 2015
Further investigation in the field is warranted to inform new translational advances that will promote to understand the pathogenesis of EH and develop novel approaches to prevent and treat EH.
The evolutionary study of susceptibility genes for essential hypertension.
Xu et al., Ningbo, China. In Yi Chuan, 2014
This review is expected to provide useful information for future genetic studies of EH and many other diseases.
Associations of pregnancy-associated plasma protein-A level with essential hypertension and hypertensive disorders in pregnancy in Chinese population: a meta-analysis of 20 research studies involving 3332 individuals.
Fu et al., Changzhou, China. In Bmj Open, 2014
CONCLUSIONS: The present meta-analysis suggests that an elevated PAPP-A level may be associated with susceptibilities to EH and HDP.
Fifty Percent Prevalence of Extracampine Hallucinations in Parkinson's Disease Patients.
Chan et al., Cambridge, United Kingdom. In Front Neurol, 2014
Data were obtained regarding the occurrence, timing, and characteristics of VH and EH and symptoms of PD, disease duration, disease severity, and medication history.
Association of NPRA and NPRC gene variants and hypertension in Mongolian population.
Zhao et al., Hohhot, China. In Genet Mol Res, 2014
There were no significant differences in the genotype and allele frequency distributions for any of the 3 single nucleotide polymorphisms in NPRA between EH and normotensive individuals.
Esophageal hypomotility and spastic motor disorders: current diagnosis and treatment.
Coss-Adame et al., Mexico. In Curr Gastroenterol Rep, 2014
The reduced excitation of the smooth muscle contraction mediated by cholinergic neurons and the impairment of inhibitory ganglion neuronal function mediated by nitric oxide are likely mechanisms of the peristaltic abnormalities seen in EH and SMD, respectively.
Two novel HAND1 mutations in Chinese patients with ventricular septal defect.
Ma et al., Beijing, China. In Clin Chim Acta, 2012
This is the first report of mutations in the HAND1 gene in Chinese patients with VSD and provides new insight into the etiology of VSD
A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis.
Firulli et al., Indianapolis, United States. In J Neurosci, 2012
Hand1 is dispensable for normal tyrosine hydroxylase and dopamine beta-hydroxylase expression in sympathetic neurons, even when Hand2 gene dosage is concurrently reduced by half.
Somatic mutations in NKX2–5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart.
Winlaw et al., Sydney, Australia. In Am J Med Genet A, 2011
Somatic mutations in NKX2-5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart.
Investigation of somatic NKX2-5, GATA4 and HAND1 mutations in patients with tetralogy of Fallot.
Fu et al., Shanghai, China. In Pathology, 2011
Our study shows no evidence of somatic NKX2-5, GATA4 and HAND1 mutations playing a role in the pathogenesis of Tetralogy of Fallot . Findings suggest that the GATA4 and HAND1 germline mutations are associated with non-syndromic congenital heart disease.
Sequence variations of NKX2-5 and HAND1 genes in patients with atrial isomerism.
Erginel Ünaltuna et al., İstanbul, Turkey. In Anadolu Kardiyol Derg, 2011
Mutations or sequence variations in HAND1 or NKX2-5 genes may play role in etiology or pathogenesis of atrial isomerism.
Nucleolar release of Hand1 acts as a molecular switch to determine cell fate.
Riley et al., London, United Kingdom. In Nat Cell Biol, 2007
The bHLH transcription factor Hand1 is essential for placentation and cardiac morphogenesis in the developing embryo.
Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1.
Olson et al., Dallas, United States. In Nat Genet, 1998
The basic helix-loop-helix (bHLH) transcription factors, Hand1 and Hand2 (refs 1,2), also called eHand/Hxt/Thing1 and dHand/Hed/Thing2 (refs 3,4), respectively, are expressed in the heart and certain neural-crest derivatives during embryogenesis.
The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis.
Cross et al., Toronto, Canada. In Nat Genet, 1998
The Hand1 gene, previously called Hxt, eHAND and Thing1, encodes a basic helix-loop-helix (bHLH) transcription factor that starts to be expressed during pre-implantation development.
share on facebooktweetadd +1mail to friends