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Early growth response 3

Egr3, Early Growth Response Protein 3
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Egr-1, Early Growth Response Protein 2, NGFI-C, CAN, Fos
Papers using Egr3 antibodies
Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis
Supplier
Tourtellotte Warren G. et al., In The Journal of Cell Biology, 1972
... Egr3 transgenic mice were generated by ...
Papers on Egr3
Adaptation to AI therapy in breast cancer can induce dynamic alterations in ER activity resulting in estrogen independent metastatic tumours.
New
Young et al., Ireland. In Clin Cancer Res, Feb 2016
The adaptive ER response to AI treatment was highlighted by the ER/AIB1 target gene, early growth response 3 (EGR3).
Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi.
New
Nde et al., Nashville, United States. In Plos Negl Trop Dis, Jan 2016
Early during infection, T. cruzi significantly upregulated transcription factors including activator protein 1 (AP1) transcription factor network components (including FOSB, FOS and JUNB), early growth response proteins 1 and 3 (EGR1, EGR3), and cytokines/chemokines (IL5, IL6, IL13, CCL11), which have all been implicated in the onset of fibrosis.
Spaceflight alters expression of microRNA during T-cell activation.
New
Li et al., San Francisco, United States. In Faseb J, Dec 2015
EGR3, FASLG, BTG2, SPRY2, and TAGAP are biologically confirmed targets and are co-up-regulated with miR-21.
Regulation of tumorigenesis and metastasis of hepatocellular carcinoma tumor endothelial cells by microRNA-3178 and underlying mechanism.
New
Yan et al., Wuhan, China. In Biochem Biophys Res Commun, Sep 2015
Early growth responsive gene 3 (EGR3), as the putative target of miR-3178, was detected through RT-PCR and Western blot.
Early Growth Response Genes 2 and 3 Regulate the Expression of Bcl6 and Differentiation of T Follicular Helper Cells.
New
Wang et al., London, United Kingdom. In J Biol Chem, Sep 2015
We have now discovered that early growth response gene 2 (EGR2) and EGR3 directly regulate the expression of Bcl6 in Tfh cells, which is required for their function in regulation of GC formation.
Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia.
New
Li et al., Beijing, China. In Biochem Biophys Res Commun, Jun 2015
In this study, we successfully created a rat model of schizophrenia by the transfection of EGR3 gene into rat brain.
Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish.
Spaink et al., Leiden, Netherlands. In Bmc Genomics, 2014
Remarkably, in the Pam3CSK4 specific set, there was a set of transcription factors with more than 2 fold-change, as confirmed by qPCR analyses, including cebpb, fosb, nr4a1 and egr3.
The reduction of volume and fiber bundle connections in the hippocampus of EGR3 transgenic schizophrenia rats.
Li et al., Nanjing, China. In Neuropsychiatr Dis Treat, 2014
In this study, we aimed to investigate the white matter connection in schizophrenia susceptible brain regions of early growth response factor 3 (EGR3) expressing rats.
Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk.
Gallitano et al., Xi'an, China. In Plos One, 2014
Accordingly, variations in the immediate early gene EGR3, and its target ARC, should influence schizophrenia susceptibility.
Family-based association study of early growth response gene 3 with child bipolar I disorder.
GeneRIF
Geller et al., Phoenix, United States. In J Affect Disord, 2012
EGR3, a gene that translates environmental stimuli into long-term changes in the brain, may be associated with risk for child bipolar disorder 1.
[A family-based association study of the EGR3 gene polymorphisms and schizophrenia].
GeneRIF
Ma et al., Xi'an, China. In Yi Chuan, 2012
EGR3 gene may play an important role in schizophrenia susceptibility
Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.
GeneRIF
Ma et al., Xi'an, China. In Plos One, 2011
Study supports the association of EGR3 with schizophrenia in Han Chinese sample.
TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors.
GeneRIF
Drexhage et al., Rotterdam, Netherlands. In Brain Behav Immun, 2011
EGR3 bound to the TREM-1 promoter.
Egr3 dependent sympathetic target tissue innervation in the absence of neuron death.
GeneRIF
Tourtellotte et al., Chicago, United States. In Plos One, 2010
a role for Egr3 in mediating sympathetic target tissue innervation that is independent of neuron survival or neurotrophin deregulation
Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer.
Review
Rubenstein et al., Valencia, Spain. In Mol Psychiatry, 2009
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
[Gene expression profile of spinal ventral horn in ALS].
Review
Sobue et al., Nagoya, Japan. In Brain Nerve, 2007
Downregulated genes in motor neurons included those associated with cytoskeleton/axonal transport, transcription and cell surface antigens/receptors, such as dynactin 1 (DCTN1) and early growth response 3 (EGR3).
Estrogen signaling and prediction of endocrine therapy.
Review
Yamaguchi et al., Sendai, Japan. In Cancer Chemother Pharmacol, 2005
Using this microarray, we investigated various aspects of estrogen signaling such as the effect of estrogen-antagonists on ERG expression profile and functional analysis of ERbeta and novel estrogen responsive gene EGR3.
Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors.
Review
Ahmed, Lexington, United States. In Curr Cancer Drug Targets, 2004
The Egr-1 gene belongs to a family of Egr genes that includes EGR-1, EGR-2, EGR-3, EGR-4, EGR-alpha and the tumor suppressor, Wilms' tumor gene product, WT1.
Integration of G-protein coupled receptor signaling pathways for activation of a transcription factor (EGR-3).
Review
Whitney et al., Beijing, China. In Genomics Proteomics Bioinformatics, 2003
The beta-lactamase tagged EGR-3 Jurkat cell was used to dissect specific GPCR signaling in vivo.
A screen for genes induced in the suprachiasmatic nucleus by light.
Impact
Weitz et al., Boston, United States. In Science, 1998
Among these genes are c-fos and nur77, two of the five early-response genes known to be induced in the SCN by light, and egr-3, a zinc finger transcription factor not previously identified in the SCN.
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